DE69630010D1 - Modifizierte Peptidsynthetasen, und deren Verwendung in der nicht-ribosomalen Herstellung von Peptiden - Google Patents

Modifizierte Peptidsynthetasen, und deren Verwendung in der nicht-ribosomalen Herstellung von Peptiden

Info

Publication number
DE69630010D1
DE69630010D1 DE69630010T DE69630010T DE69630010D1 DE 69630010 D1 DE69630010 D1 DE 69630010D1 DE 69630010 T DE69630010 T DE 69630010T DE 69630010 T DE69630010 T DE 69630010T DE 69630010 D1 DE69630010 D1 DE 69630010D1
Authority
DE
Germany
Prior art keywords
peptides
modified peptide
peptide synthetases
ribosomal
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69630010T
Other languages
English (en)
Inventor
Guido Grandi
Ferra Francesca De
Francesco Rodrigues
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eni Tecnologie SpA
Original Assignee
Eniricerche SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche SpA filed Critical Eniricerche SpA
Application granted granted Critical
Publication of DE69630010D1 publication Critical patent/DE69630010D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69630010T 1995-08-09 1996-06-20 Modifizierte Peptidsynthetasen, und deren Verwendung in der nicht-ribosomalen Herstellung von Peptiden Expired - Lifetime DE69630010D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001764A IT1277466B1 (it) 1995-08-09 1995-08-09 Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi

Publications (1)

Publication Number Publication Date
DE69630010D1 true DE69630010D1 (de) 2003-10-23

Family

ID=11372167

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69630010T Expired - Lifetime DE69630010D1 (de) 1995-08-09 1996-06-20 Modifizierte Peptidsynthetasen, und deren Verwendung in der nicht-ribosomalen Herstellung von Peptiden

Country Status (5)

Country Link
US (1) US5795738A (de)
EP (1) EP0789078B1 (de)
AT (1) ATE250129T1 (de)
DE (1) DE69630010D1 (de)
IT (1) IT1277466B1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040005673A1 (en) * 2001-06-29 2004-01-08 Kevin Jarrell System for manipulating nucleic acids
US6358712B1 (en) 1999-01-05 2002-03-19 Trustee Of Boston University Ordered gene assembly
JP2002537762A (ja) * 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
DE19909146A1 (de) * 1999-03-03 2000-09-28 Mohamed A Marahiel Verfahren zur gezielten biologischen Synthese von Peptiden
EP1096011A1 (de) * 1999-05-10 2001-05-02 Holland Sweetener Company V.o.F. Mikrobiologisches Verfahren zur Herstellung von Alpha-L-Aspartyl-L-Phenylalanin
DE19928313A1 (de) * 1999-06-16 2000-12-21 Ullrich Keller Verfahren zur Veränderung von Peptidsynthefasen in der Weise, daß sie ihre Substrataminosäuren N-methylieren können
FR2796465B1 (fr) * 1999-07-16 2001-11-23 Suisse Electronique Microtech Systeme capteur biochimique a sensibilite accrue par amplification moleculaire du signal
KR20100039443A (ko) * 2001-08-06 2010-04-15 큐비스트 파마슈티컬즈 인코포레이티드 답토마이신 생합성 유전자 클러스터에 관련된 조성물 및 방법
AU2003296151A1 (en) 2002-12-26 2004-07-22 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptide
US20080051326A1 (en) * 2004-11-12 2008-02-28 Alexander Dylan C Antiinfective Lipopeptides
US9081199B2 (en) * 2005-03-18 2015-07-14 Kyowa Hakko Bio Co., Ltd. Process for the production of dipeptides by a dipeptide-synthesizing enzyme
US20090325155A1 (en) * 2005-08-26 2009-12-31 Elhammer Ake P Aureobasin a synthetase
US20090197303A1 (en) * 2005-12-27 2009-08-06 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptides
WO2008131014A1 (en) * 2007-04-16 2008-10-30 Modular Genetics, Inc. Lipopeptides and lipopeptide synthetases
WO2008131002A2 (en) 2007-04-16 2008-10-30 Modular Genetics, Inc. Generation of acyl amino acids
WO2009028253A1 (ja) * 2007-08-31 2009-03-05 Kyowa Hakko Bio Co., Ltd. ペプチドの製造法
RU2012129311A (ru) 2012-07-11 2014-01-20 Закрытое акционерное общество " Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Днк, кодирующая дипептид-синтезирующий фермер (варианты), бактерия рода escherichia и способ получения дипептидов с ее использованием
EP2970928A4 (de) 2013-03-15 2017-02-15 Modular Genetics, Inc. Erzeugung von acylaminosäuren
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0540074A1 (de) * 1991-10-09 1993-05-05 ENIRICERCHE S.p.A. Klonierung und Sequenzierung der chromosomalen DNS-Region aus Bacillus subtilis, die den für den Multienzym-Komplex Surfactin-Synthetase kodierenden SRFA Operon enthält
IT1264712B1 (it) * 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi

Also Published As

Publication number Publication date
US5795738A (en) 1998-08-18
EP0789078A3 (de) 1999-10-27
ATE250129T1 (de) 2003-10-15
ITMI951764A1 (it) 1997-02-09
IT1277466B1 (it) 1997-11-10
EP0789078A2 (de) 1997-08-13
ITMI951764A0 (it) 1995-08-09
EP0789078B1 (de) 2003-09-17

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