DE69623593T2 - Feststoffe enthaltend valproinsäure und natriumvalproat - Google Patents

Feststoffe enthaltend valproinsäure und natriumvalproat

Info

Publication number
DE69623593T2
DE69623593T2 DE69623593T DE69623593T DE69623593T2 DE 69623593 T2 DE69623593 T2 DE 69623593T2 DE 69623593 T DE69623593 T DE 69623593T DE 69623593 T DE69623593 T DE 69623593T DE 69623593 T2 DE69623593 T2 DE 69623593T2
Authority
DE
Germany
Prior art keywords
valproat
sodium
solids containing
valproinic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69623593T
Other languages
English (en)
Other versions
DE69623593D1 (de
Inventor
Bernard Charles Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69623593D1 publication Critical patent/DE69623593D1/de
Publication of DE69623593T2 publication Critical patent/DE69623593T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
DE69623593T 1995-02-02 1996-01-19 Feststoffe enthaltend valproinsäure und natriumvalproat Expired - Fee Related DE69623593T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ270438A NZ270438A (en) 1995-02-02 1995-02-02 Solid (granular) mixture of valproic acid (di-n-propyl acetic acid) and its sodium salt; pharmaceutical compositions
PCT/CA1996/000040 WO1996023491A1 (en) 1995-02-02 1996-01-19 Solid substances comprising valproic acid and sodium valproate

Publications (2)

Publication Number Publication Date
DE69623593D1 DE69623593D1 (de) 2002-10-17
DE69623593T2 true DE69623593T2 (de) 2003-06-05

Family

ID=19925134

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69623593T Expired - Fee Related DE69623593T2 (de) 1995-02-02 1996-01-19 Feststoffe enthaltend valproinsäure und natriumvalproat

Country Status (7)

Country Link
US (1) US6077542A (de)
EP (1) EP0808161B1 (de)
AU (1) AU689364B2 (de)
CA (1) CA2172603C (de)
DE (1) DE69623593T2 (de)
NZ (1) NZ270438A (de)
WO (1) WO1996023491A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6419953B1 (en) 1998-12-18 2002-07-16 Abbott Laboratories Controlled release formulation of divalproex sodium
US6713086B2 (en) 1998-12-18 2004-03-30 Abbott Laboratories Controlled release formulation of divalproex sodium
US6511678B2 (en) 1998-12-18 2003-01-28 Abbott Laboratories Controlled release formulation of divalproex sodium
US20020031549A1 (en) * 1998-12-18 2002-03-14 Yihong Qiu Controlled release formulation of divalproex sodium
US6528090B2 (en) 1998-12-18 2003-03-04 Abbott Laboratories Controlled release formulation of divalproex sodium
CA2387958C (en) * 1999-11-02 2010-02-02 Cilag Ag Method of preparing valproic acid compounds
AT408718B (de) * 1999-12-02 2002-02-25 Gerot Pharmazeutika Natriumvalproat-granulat mit verringerter hygroskopizität
US20020127277A1 (en) * 2000-12-22 2002-09-12 Yihong Qiu Solid dosage forms of divalproex sodium
US6610326B2 (en) * 2001-02-16 2003-08-26 Andrx Corporation Divalproex sodium tablets
US20050276848A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Sustained release neutralized divalproex sodium
US7713550B2 (en) * 2004-06-15 2010-05-11 Andrx Corporation Controlled release sodium valproate formulation
US20050276849A1 (en) * 2004-06-15 2005-12-15 Nilobon Podhipleux Sustained release dosage forms
CN105380935B (zh) * 2014-09-03 2018-04-03 长春海悦药业股份有限公司 一种丙戊酸钠药物组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212326A (en) * 1979-08-20 1993-05-18 Abbott Laboratories Sodium hydrogen divalproate oligomer
IL72381A (en) * 1983-07-20 1988-03-31 Sanofi Sa Pharmaceutical composition based on valproic acid
JPS61174940A (ja) * 1985-01-29 1986-08-06 Oogawara Kakoki Kk ワックス類コーテイング単核状マイクロカプセルおよびその製造方法
FR2643556B1 (fr) * 1989-02-27 1993-03-05 Sanofi Sa Composition pharmaceutique a liberation prolongee d'acide valproique

Also Published As

Publication number Publication date
CA2172603A1 (en) 1996-08-03
WO1996023491A1 (en) 1996-08-08
AU689364B2 (en) 1998-03-26
EP0808161B1 (de) 2002-09-11
DE69623593D1 (de) 2002-10-17
EP0808161A1 (de) 1997-11-26
US6077542A (en) 2000-06-20
CA2172603C (en) 1997-02-04
AU4477096A (en) 1996-08-21
NZ270438A (en) 1996-03-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee