DE69620593T2 - Hexacyclische camptothecinanaloga und verfahren zu deren herstellung - Google Patents

Hexacyclische camptothecinanaloga und verfahren zu deren herstellung

Info

Publication number
DE69620593T2
DE69620593T2 DE69620593T DE69620593T DE69620593T2 DE 69620593 T2 DE69620593 T2 DE 69620593T2 DE 69620593 T DE69620593 T DE 69620593T DE 69620593 T DE69620593 T DE 69620593T DE 69620593 T2 DE69620593 T2 DE 69620593T2
Authority
DE
Germany
Prior art keywords
camptothecinanaloga
hexacyclic
production
hexacyclic camptothecinanaloga
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69620593T
Other languages
English (en)
Other versions
DE69620593D1 (de
Inventor
Angelo Bedeschi
Ilaria Candiani
Franco Zarini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia SpA filed Critical Pharmacia Italia SpA
Application granted granted Critical
Publication of DE69620593D1 publication Critical patent/DE69620593D1/de
Publication of DE69620593T2 publication Critical patent/DE69620593T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69620593T 1996-01-10 1996-12-17 Hexacyclische camptothecinanaloga und verfahren zu deren herstellung Expired - Fee Related DE69620593T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9600438.7A GB9600438D0 (en) 1996-01-10 1996-01-10 Hexacyclic camptothecin analogues, and process for preparing them
PCT/EP1996/005752 WO1997025332A1 (en) 1996-01-10 1996-12-17 Hexacyclic camptothecin analogues, and process for preparing them

Publications (2)

Publication Number Publication Date
DE69620593D1 DE69620593D1 (de) 2002-05-16
DE69620593T2 true DE69620593T2 (de) 2002-11-28

Family

ID=10786827

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69620593T Expired - Fee Related DE69620593T2 (de) 1996-01-10 1996-12-17 Hexacyclische camptothecinanaloga und verfahren zu deren herstellung

Country Status (7)

Country Link
US (1) US5990120A (de)
EP (1) EP0813535B1 (de)
JP (1) JPH11502871A (de)
DE (1) DE69620593T2 (de)
ES (1) ES2175181T3 (de)
GB (1) GB9600438D0 (de)
WO (1) WO1997025332A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9702807D0 (en) 1997-02-12 1997-04-02 Pharmacia & Upjohn Spa Alkynyl-substituted camptothecins and process for their preparation
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
JP5170741B2 (ja) 2004-04-27 2013-03-27 ウェルスタット バイオロジクス コーポレイション ウイルスおよびカンプトテシン類を使用する癌の処置
CN1300147C (zh) * 2004-10-18 2007-02-14 中国药科大学 喜树碱衍生物的制备方法
JP5190958B2 (ja) 2005-07-14 2013-04-24 ウェルスタット バイオロジクス コーポレイション ウイルス、フルオロピリミジンおよびカンプトテシンを使用した癌の処置
CN100586952C (zh) * 2006-11-10 2010-02-03 中国药科大学 噁唑骈喜树碱酯衍生物及其制备方法和用途
CN102659800B (zh) * 2012-05-11 2014-09-03 中国药科大学 一类低氧激活抗肿瘤化合物及其用途
JP6877049B2 (ja) 2015-09-25 2021-05-26 ゼットワイ セラピューティクス インク．Ｚｙ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． 多糖類−ビタミン共役体を含む粒状物に基づく薬物製剤
CN108017656B (zh) * 2016-11-03 2020-01-07 深圳瀜新生物科技有限公司 喜树碱衍生物及其在制备抗肿瘤药物中的应用
CN109467563B (zh) * 2018-06-08 2021-08-03 浙江大学 一种喜树碱衍生物及其在制备抗炎症药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin
EP0658537B1 (de) * 1993-12-01 1999-03-31 Ichikawa Gosei Chemical Co., Ltd. Verfahren zur Herstellung von cis-1-Aminoindan-2-ol
US5670500A (en) * 1995-05-31 1997-09-23 Smithkline Beecham Corporation Water soluble camptothecin analogs

Also Published As

Publication number Publication date
US5990120A (en) 1999-11-23
EP0813535A1 (de) 1997-12-29
JPH11502871A (ja) 1999-03-09
WO1997025332A1 (en) 1997-07-17
GB9600438D0 (en) 1996-03-13
ES2175181T3 (es) 2002-11-16
DE69620593D1 (de) 2002-05-16
EP0813535B1 (de) 2002-04-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee