DE69616276D1 - Verfahren zur produktion von proteinen - Google Patents

Verfahren zur produktion von proteinen

Info

Publication number
DE69616276D1
DE69616276D1 DE69616276T DE69616276T DE69616276D1 DE 69616276 D1 DE69616276 D1 DE 69616276D1 DE 69616276 T DE69616276 T DE 69616276T DE 69616276 T DE69616276 T DE 69616276T DE 69616276 D1 DE69616276 D1 DE 69616276D1
Authority
DE
Germany
Prior art keywords
producing proteins
protein
yeast
genes
concerns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69616276T
Other languages
English (en)
Other versions
DE69616276T2 (de
Inventor
Bernd Meyhack
Michael Broeker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Pharma GmbH
Novartis AG
Sanofi Aventis Deutschland GmbH
Original Assignee
Novartis Erfindungen Verwaltungs GmbH
Novartis AG
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Erfindungen Verwaltungs GmbH, Novartis AG, Hoechst AG filed Critical Novartis Erfindungen Verwaltungs GmbH
Publication of DE69616276D1 publication Critical patent/DE69616276D1/de
Application granted granted Critical
Publication of DE69616276T2 publication Critical patent/DE69616276T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8132—Plasminogen activator inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69616276T 1995-02-09 1996-01-26 Verfahren zur produktion von proteinen Expired - Lifetime DE69616276T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95810084 1995-02-09
PCT/EP1996/000314 WO1996024678A1 (en) 1995-02-09 1996-01-26 Process for the production of proteins

Publications (2)

Publication Number Publication Date
DE69616276D1 true DE69616276D1 (de) 2001-11-29
DE69616276T2 DE69616276T2 (de) 2002-12-12

Family

ID=8221698

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616276T Expired - Lifetime DE69616276T2 (de) 1995-02-09 1996-01-26 Verfahren zur produktion von proteinen

Country Status (10)

Country Link
US (2) US5981227A (de)
EP (1) EP0801682B1 (de)
JP (1) JP3732516B2 (de)
AT (1) ATE207538T1 (de)
AU (1) AU707657B2 (de)
DE (1) DE69616276T2 (de)
DK (1) DK0801682T3 (de)
ES (1) ES2167537T3 (de)
PT (1) PT801682E (de)
WO (1) WO1996024678A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0801682B1 (de) * 1995-02-09 2001-10-24 Novartis AG Verfahren zur produktion von proteinen
FR2801902B1 (fr) * 1999-12-01 2005-03-04 Centre Nat Rech Scient Procedes de criblages fonctionnels d'agents aptes a moduler l'activite des complexes ubiquitine-ligases scf et leurs applications
FR2823764B1 (fr) * 2001-04-24 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides du gene ifn alpha-17

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2108510B (en) 1981-10-03 1984-12-12 Ciba Geigy Ag Dnas, recombinant dnas, hosts containing them, polypeptides and processes for the production thereof
DE3479520D1 (en) 1983-11-21 1989-09-28 Ciba Geigy Ag Synthesis of tissue plasminogen activator(tpa) by yeast
US4923807A (en) * 1984-05-18 1990-05-08 New England Medical Center Hospitals Inc. Arg-Serpin human plasminogen activator inhibitor designated PAI-2
ATE78262T1 (de) 1985-06-11 1992-08-15 Ciba Geigy Ag Hybrid-interferone.
MY101203A (en) 1985-12-12 1991-08-17 Ucp Gen Pharma Ag Production of thrombin iinhibitors.
AU614121B2 (en) * 1988-05-04 1991-08-22 Novartis Ag Improvements in the production of polypeptides
CA1324969C (en) * 1988-05-06 1993-12-07 Jeffrey R. Shuster High level expression of proteins in yeast
JPH02150283A (ja) * 1988-07-21 1990-06-08 Takeda Chem Ind Ltd 発現プラスミドおよびその用途
WO1990005184A1 (en) * 1988-11-04 1990-05-17 Chiron Corporation Expression and processing of authentic fgf's in yeast
FI103206B1 (fi) * 1990-01-29 1999-05-14 Novartis Ag Uusi ilmentämisjärjestelmä sieniä varten
EP0717106B1 (de) * 1994-12-16 2000-03-15 Chiron Behring Gmbh & Co. Immunogenes Hybridprotein OprF-Oprl erhältlich aus Membranproteinen von Pseudomonas aeruginosa
EP0801682B1 (de) * 1995-02-09 2001-10-24 Novartis AG Verfahren zur produktion von proteinen

Also Published As

Publication number Publication date
US5981227A (en) 1999-11-09
AU707657B2 (en) 1999-07-15
AU4487496A (en) 1996-08-27
ES2167537T3 (es) 2002-05-16
EP0801682A1 (de) 1997-10-22
ATE207538T1 (de) 2001-11-15
DK0801682T3 (da) 2002-02-18
DE69616276T2 (de) 2002-12-12
US6284520B1 (en) 2001-09-04
EP0801682B1 (de) 2001-10-24
JP3732516B2 (ja) 2006-01-05
PT801682E (pt) 2002-03-28
JPH10513353A (ja) 1998-12-22
WO1996024678A1 (en) 1996-08-15

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH AVENTIS PHARMA DEUTSCHLAND

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, 65929 FRANKFURT,

Owner name: NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H

8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN