DE69609415D1 - Verbesserte synthese von tyrosin-abgeleiteten diphenolmonomeren. - Google Patents

Verbesserte synthese von tyrosin-abgeleiteten diphenolmonomeren.

Info

Publication number
DE69609415D1
DE69609415D1 DE69609415T DE69609415T DE69609415D1 DE 69609415 D1 DE69609415 D1 DE 69609415D1 DE 69609415 T DE69609415 T DE 69609415T DE 69609415 T DE69609415 T DE 69609415T DE 69609415 D1 DE69609415 D1 DE 69609415D1
Authority
DE
Germany
Prior art keywords
tyrosine
improved synthesis
derived diphenol
diphenol monomers
monomers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69609415T
Other languages
English (en)
Other versions
DE69609415T2 (de
Inventor
B Kohn
Ann Hooper
J Brocchini
L Schwartz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Application granted granted Critical
Publication of DE69609415D1 publication Critical patent/DE69609415D1/de
Publication of DE69609415T2 publication Critical patent/DE69609415T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44Polyester-amides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/02Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/68Polyesters containing atoms other than carbon, hydrogen and oxygen
    • C08G63/685Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen
    • C08G63/6854Polyesters containing atoms other than carbon, hydrogen and oxygen containing nitrogen derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/6856Dicarboxylic acids and dihydroxy compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/04Aromatic polycarbonates
    • C08G64/06Aromatic polycarbonates not containing aliphatic unsaturation
    • C08G64/08Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen
    • C08G64/12Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen containing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69609415T 1995-03-31 1996-03-29 Verbesserte synthese von tyrosin-abgeleiteten diphenolmonomeren. Expired - Lifetime DE69609415T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/414,339 US5587507A (en) 1995-03-31 1995-03-31 Synthesis of tyrosine derived diphenol monomers
PCT/US1996/004387 WO1996030331A1 (en) 1995-03-31 1996-03-29 Improved synthesis of tyrosine-derived diphenol monomers

Publications (2)

Publication Number Publication Date
DE69609415D1 true DE69609415D1 (de) 2000-08-24
DE69609415T2 DE69609415T2 (de) 2001-01-25

Family

ID=23641027

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69609415T Expired - Lifetime DE69609415T2 (de) 1995-03-31 1996-03-29 Verbesserte synthese von tyrosin-abgeleiteten diphenolmonomeren.

Country Status (5)

Country Link
US (3) US5587507A (de)
EP (1) EP0824513B1 (de)
CA (1) CA2215281C (de)
DE (1) DE69609415T2 (de)
WO (1) WO1996030331A1 (de)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6120491A (en) * 1997-11-07 2000-09-19 The State University Rutgers Biodegradable, anionic polymers derived from the amino acid L-tyrosine
US6319492B1 (en) * 1996-11-27 2001-11-20 Rutgers, The State University Copolymers of tyrosine-based polyarylates and poly(alkylene oxides)
US6048521A (en) * 1997-11-07 2000-04-11 Rutgers, The State University Copolymers of tyrosine-based polyarlates and poly(alkylene oxides)
WO1998036013A1 (en) * 1997-02-18 1998-08-20 Rutgers, The State University Monomers derived from hydroxy acids and polymers prepared therefrom
ATE248877T1 (de) * 1997-06-27 2003-09-15 Integra Lifesciences I Ltd Zwei-phasen polymerisationsverfahren
US7514074B2 (en) 1997-07-14 2009-04-07 Osiris Therapeutics, Inc. Cardiac muscle regeneration using mesenchymal stem cells
ES2226191T3 (es) * 1997-11-07 2005-03-16 Rutgers, The State University Copolimeros de poli (oxido de aquileno) estrictamente alternantes.
US6602497B1 (en) 1997-11-07 2003-08-05 Rutgers, The State University Strictly alternating poly(alkylene oxide ether) copolymers
US6623521B2 (en) 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US7713297B2 (en) * 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
JP4312384B2 (ja) * 1998-04-13 2009-08-12 ラットガーズ ザ ステイト ユニヴァーシティ コポリマーライブラリーの構築
US8133421B2 (en) * 1999-02-23 2012-03-13 Warsaw Orthopedic, Inc. Methods of making shaped load-bearing osteoimplant
US20070233272A1 (en) * 1999-02-23 2007-10-04 Boyce Todd M Shaped load-bearing osteoimplant and methods of making same
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
CA2396037A1 (en) * 1999-12-31 2001-07-12 Rutgers, The State University Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix
EP1251864A4 (de) * 1999-12-31 2006-02-22 Univ Rutgers Pharmazeutische formulierung bestehend aus einer polymer-mischung und einer aktiven verbindung zur zeit-gesteuerten freisetzung
US7521061B2 (en) * 1999-12-31 2009-04-21 Rutgers, The State University Of New Jersey Pharmaceutical formulation for regulating the timed release of biologically active compounds based on a polymer matrix
AU2001288829A1 (en) 2000-09-06 2002-03-22 Ap Pharma, Inc. Degradable polyacetal polymers
US7727221B2 (en) 2001-06-27 2010-06-01 Cardiac Pacemakers Inc. Method and device for electrochemical formation of therapeutic species in vivo
US7271234B2 (en) * 2002-04-24 2007-09-18 Rutgers, The State University Of New Jersey Polyarylates for drug delivery and tissue engineering
US20060182752A1 (en) * 2003-05-15 2006-08-17 Rutgers, The State University Tri-block polymers for nanosphere-based drug or gene delivery
WO2004039944A2 (en) * 2002-05-15 2004-05-13 Rutgers, The State University Tri-block polymers for nanosphere-based drug or gene delivery
US8591951B2 (en) * 2002-05-15 2013-11-26 Joachim B. Kohn Tri-block copolymers for nanosphere-based drug delivery
US20050251267A1 (en) * 2004-05-04 2005-11-10 John Winterbottom Cell permeable structural implant
US6916868B2 (en) * 2003-01-23 2005-07-12 Integra Lifesciences Corporation Selective modification of pendent functionalities of polymers
US7488343B2 (en) * 2003-09-16 2009-02-10 Boston Scientific Scimed, Inc. Medical devices
RU2373958C2 (ru) 2003-09-25 2009-11-27 Рутгерс, Дзе Стейт Юниверсити Полимерные по существу рентгеноконтрастные продукты для эмболотерапии
US7368169B2 (en) * 2003-12-01 2008-05-06 Rutgers, The State University Of New Jersey Hydrazide compounds with angiogenic activity
CA2550431A1 (en) 2003-12-19 2005-07-14 Osteotech, Inc. Tissue-derived mesh for orthopedic regeneration
JP2007519492A (ja) * 2004-01-30 2007-07-19 オステオテック,インコーポレイテッド 脊椎融合のための積み重ねインプラント
US8137397B2 (en) 2004-02-26 2012-03-20 Boston Scientific Scimed, Inc. Medical devices
US20060100696A1 (en) * 2004-11-10 2006-05-11 Atanasoska Ljiljana L Medical devices and methods of making the same
US8703113B2 (en) * 2004-07-08 2014-04-22 Reva Medical Inc. Side-chain crystallizable polymers for medical applications
EP1776407B1 (de) * 2004-07-08 2019-06-12 Reva Medical, Inc. Seitenkettenkristallisierbare polymere für medizinische anwendungen
US7763065B2 (en) 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
EP1923075B1 (de) 2004-08-13 2015-11-11 Rutgers, The State University Röntgendichte Polymerstents
US20060034769A1 (en) * 2004-08-13 2006-02-16 Rutgers, The State University Radiopaque polymeric stents
RU2396289C2 (ru) * 2004-08-13 2010-08-10 Рева Медикал, Инк. Саморассасывающиеся рентгеноконтрастные по своей природе полимеры для многоцелевого использования
EP1789097B1 (de) 2004-08-13 2014-08-13 Rutgers, The State University Röntgendichte polymerstents
US8292944B2 (en) 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
US20060276910A1 (en) * 2005-06-01 2006-12-07 Jan Weber Endoprostheses
US7914574B2 (en) 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
ES2718681T3 (es) 2005-11-03 2019-07-03 Tyrx Inc Polímeros fenólicos resorbibles
US8007526B2 (en) * 2005-12-01 2011-08-30 Bezwada Biomedical, Llc Difunctionalized aromatic compounds and polymers therefrom
US7935843B2 (en) 2005-12-09 2011-05-03 Bezwada Biomedical, Llc Functionalized diphenolics and absorbable polymers therefrom
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8287914B2 (en) 2006-01-12 2012-10-16 Rutgers, The State University Of New Jersey Biomimetic hydroxyapatite synthesis
EP1976460A4 (de) 2006-01-19 2012-06-20 Warsaw Orthopedic Inc Injizierbare und formbare knochenersatzmaterialien
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
EP2114298B1 (de) 2006-02-08 2022-10-19 Medtronic, Inc. Vorübergehend versteifte maschenprothesen
US8591531B2 (en) * 2006-02-08 2013-11-26 Tyrx, Inc. Mesh pouches for implantable medical devices
US8315700B2 (en) * 2006-02-08 2012-11-20 Tyrx, Inc. Preventing biofilm formation on implantable medical devices
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
WO2007115368A1 (en) * 2006-04-07 2007-10-18 The University Of Queensland Porous polymer structures
US8044108B2 (en) * 2006-04-07 2011-10-25 The University Of Queensland Porous polymer blend structures
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
EP2044142A2 (de) * 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester)polymere sowie herstellungs- und verwendungsverfahren dafür
JP2009542359A (ja) 2006-06-29 2009-12-03 ボストン サイエンティフィック リミテッド 選択的被覆部を備えた医療装置
EP2054537A2 (de) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprothese mit dreidimensionaler desintegrationssteuerung
EP2068757B1 (de) 2006-09-14 2011-05-11 Boston Scientific Limited Medizinprodukte mit wirkstofffreisetzender beschichtung
EP2399616A1 (de) 2006-09-15 2011-12-28 Boston Scientific Scimed, Inc. Biologisch erodierbare Endoprothese mit biostabilen anorganischen Schichten
JP2010503489A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生体内分解性内部人工器官およびその製造方法
EP2068782B1 (de) 2006-09-15 2011-07-27 Boston Scientific Limited Biologisch erodierbare endoprothesen
JP2010503488A (ja) * 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 磁化された生体内分解性の内部人工器官
CA2663303A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Endoprosthesis with adjustable surface features
CA2663220A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
JP2010503482A (ja) 2006-09-18 2010-02-04 ボストン サイエンティフィック リミテッド 内部人工器官
RU2470040C2 (ru) * 2006-10-17 2012-12-20 Ратджерс, Те Стейт Юниверсити Оф Нью Джерси N-замещенные мономеры и полимеры
EP2079416A4 (de) * 2006-10-30 2012-06-27 Univ Rutgers Elektrospinn-matrizen zur ausgabe hydrophiler und lipophiler verbindungen
US9023114B2 (en) 2006-11-06 2015-05-05 Tyrx, Inc. Resorbable pouches for implantable medical devices
JP2010508915A (ja) 2006-11-06 2010-03-25 タイレックス・ファーマ・インコーポレイテッド 埋込型医療機器のためのメッシュパウチ
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
US8728170B1 (en) 2006-12-28 2014-05-20 Boston Scientific Scimed, Inc. Bioerodible nano-fibrous and nano-porous conductive composites
EP2277563B1 (de) 2006-12-28 2014-06-25 Boston Scientific Limited Biologisch abbaubare endoprothesen und verfahren zur herstellung derselben.
US7704275B2 (en) 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
CN101668512A (zh) 2007-01-31 2010-03-10 新泽西鲁特格斯州立大学 皮肤中活性物质的控制释放
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
CA2682190C (en) * 2007-03-29 2015-01-27 Tyrx Pharma, Inc. Biodegradable, polymer coverings for breast implants
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
WO2008137807A1 (en) 2007-05-02 2008-11-13 Tyrx Pharma, Inc. Dihydroxybenzoate polymers and uses thereof
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2187988B1 (de) 2007-07-19 2013-08-21 Boston Scientific Limited Endoprothese mit nicht verschmutzender oberfläche
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
WO2009018340A2 (en) 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
EP2185103B1 (de) 2007-08-03 2014-02-12 Boston Scientific Scimed, Inc. Überzug für ein medizinprodukt mit vergrösserter oberfläche
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7988721B2 (en) 2007-11-30 2011-08-02 Reva Medical, Inc. Axially-radially nested expandable device
US20090192554A1 (en) * 2008-01-29 2009-07-30 Confluent Surgical, Inc. Bioabsorbable block copolymer
WO2009105692A1 (en) 2008-02-21 2009-08-27 Rutgers, The State University Of New Jersey Compositions and methods for treating ophthalmic diseases
WO2009119258A1 (ja) * 2008-03-27 2009-10-01 テルモ株式会社 生体吸収性材料およびそれを用いた生体内留置物
US8940315B2 (en) 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
JP5581311B2 (ja) 2008-04-22 2014-08-27 ボストン サイエンティフィック サイムド,インコーポレイテッド 無機材料のコーティングを有する医療デバイス及びその製造方法
WO2009132176A2 (en) 2008-04-24 2009-10-29 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
WO2009149093A1 (en) 2008-06-02 2009-12-10 University Of Medicine And Dentistry Of New Jersey Tissue engineered fibrocartilage replacement
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8652525B2 (en) * 2008-07-10 2014-02-18 Tyrx, Inc. NSAID delivery from polyarylates
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
JP5671463B2 (ja) 2008-09-22 2015-02-18 タイレックス・インコーポレイテッドTyrx Inc. アミノフェノールエステルからの直鎖ポリエステルアミド
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
CN102245127B (zh) 2008-10-10 2014-06-11 雷瓦医药公司 可扩展的滑动和锁定支架
WO2010042917A1 (en) 2008-10-11 2010-04-15 Rutgers, The State University Of New Jersey Phase-separated biocompatible polymer compositions for medical uses
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US9839628B2 (en) 2009-06-01 2017-12-12 Tyrx, Inc. Compositions and methods for preventing sternal wound infections
US9080015B2 (en) 2009-07-31 2015-07-14 Rutgers, The State University Of New Jersey Biocompatible polymers for medical devices
US8409279B2 (en) 2009-10-01 2013-04-02 Lipose Corporation Breast implant implantation method and apparatus
JP6031355B2 (ja) 2009-10-11 2016-11-24 ラトガース,ザ ステート ユニバーシティ オブ ニュー ジャージー 医療装置のための生体適合性重合体
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
CA2795292A1 (en) 2010-04-10 2011-10-13 Reva Medical, Inc. Expandable slide and lock stent
AU2011293344B2 (en) 2010-08-25 2015-07-30 Medtronic, Inc. Novel medical device coatings
US8883861B2 (en) 2010-11-01 2014-11-11 Rutgers, The State University Of New Jersey Iminic monomers and polymers thereof
WO2012064963A1 (en) 2010-11-12 2012-05-18 Tyrx, Inc. Anchorage devices comprising an active pharmaceutical ingredient
US9381281B2 (en) 2011-07-20 2016-07-05 Tyrx, Inc. Drug eluting mesh to prevent infection of indwelling transdermal devices
US11472918B2 (en) 2012-02-03 2022-10-18 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
EP3312155B1 (de) 2012-02-03 2020-08-05 Rutgers, The State University of New Jersey Polymere biomaterialien aus phenolischen monomeren und deren medizinische verwendungen
WO2014137454A1 (en) 2013-03-07 2014-09-12 Tyrx, Inc. Methods and compositions to inhibit the assemblage of microbial cells irreversibly associated with surfaces of medical devices
US9408732B2 (en) 2013-03-14 2016-08-09 Reva Medical, Inc. Reduced-profile slide and lock stent
WO2015069305A1 (en) 2013-11-08 2015-05-14 Tyrx, Inc. Antimicrobial compositions and methods for preventing infection in surgical incision sites
WO2016103224A2 (en) 2014-12-23 2016-06-30 Rutgers, The State University Of New Jersey Biocompatible iodinated diphenol monomers and polymers
US10774030B2 (en) 2014-12-23 2020-09-15 Rutgers, The State University Of New Jersey Polymeric biomaterials derived from phenolic monomers and their medical uses
WO2018081388A1 (en) 2016-10-26 2018-05-03 Washington University Compositions comprising desaminotyrosine and uses thereof to enhance type i interferon stimulation
CA3053366A1 (en) 2017-02-13 2018-08-16 Rutgers, The State University Of New Jersey Polymer filament reinforced scaffold for partial meniscus regeneration
US10442757B2 (en) * 2017-06-07 2019-10-15 Medtronic, Inc. Synthesis of tyrosine derived diphenol monomers

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4638045A (en) * 1985-02-19 1987-01-20 Massachusetts Institute Of Technology Non-peptide polyamino acid bioerodible polymers
US4980449A (en) 1988-07-14 1990-12-25 Rutgers, The State University Polyiminocarbonate synthesis
US5198507A (en) * 1990-06-12 1993-03-30 Rutgers, The State University Of New Jersey Synthesis of amino acid-derived bioerodible polymers
US5216115A (en) * 1990-06-12 1993-06-01 Rutgers, The State University Of New Jersey Polyarylate containing derivatives of the natural amino acid L-tyrosine
US5099060A (en) * 1990-06-12 1992-03-24 Rutgers, The State University Of New Jersey Synthesis of amino acid-derived bioerodible polymers
IE921942A1 (en) * 1992-06-16 1993-12-29 Gary A Siwruk John S Eynon Liquid phase synthesis of peptides and peptide derivatives

Also Published As

Publication number Publication date
DE69609415T2 (de) 2001-01-25
EP0824513A1 (de) 1998-02-25
CA2215281A1 (en) 1996-10-03
CA2215281C (en) 2004-02-24
EP0824513A4 (de) 1998-02-25
US5587507A (en) 1996-12-24
EP0824513B1 (de) 2000-07-19
US5670602A (en) 1997-09-23
USRE37795E1 (en) 2002-07-16
WO1996030331A1 (en) 1996-10-03

Similar Documents

Publication Publication Date Title
DE69609415T2 (de) Verbesserte synthese von tyrosin-abgeleiteten diphenolmonomeren.
DE69605282T2 (de) Synthese von cyclopropylacetylen
DE69620399T2 (de) Sprachsynthese
NO976007D0 (no) Polymer manokomposittdannelse ved emulsjonsyntese
DZ2013A1 (fr) Catalyseurs.
NO982850D0 (no) Ny syntese
ATE196463T1 (de) Assymetrische synthese von (-) 6-chloro-4-
DE69629185D1 (de) Synthese von am ende ungesättigten polymeren
DE69501534D1 (de) Synthese von 1,1,1,3,3-Pentafluorpropan
IT1277696B1 (it) Catalizzatori per la polimerizzazione di alfa-olefine
ZA965853B (en) Asymmetric synthesis of r and s warfarin and its analogs.
ATE231507T1 (de) Synthese von azyklischen nukleosiden
DK0813586T3 (da) Mugfjernelsesprodukt
SE9501657L (sv) Signalseparation
DE69226706T2 (de) Synthese von smektit-tonmineralen
MA23980A1 (fr) Nouveaux sulfonamides
DE69107164D1 (de) Synthesis von Ethylamine.
DE69624759T2 (de) Synthese von Difluormethan
DE69603578T2 (de) Synthese von tetrafluorethylen
FR2672591B1 (fr) Synthese d'hydrogeno-perfluoroalcanes.
DE59606269D1 (de) Alkenyl-Benzoylguanidine
DE69707656T2 (de) Synthese von cycloalkyldiarylphosphin
DE59602487D1 (de) Klassierer
AU5437496A (en) Improved synthesis of tyrosine-derived diphenol monomers
DE69708273T2 (de) Synthese von cycloalkyldiarylphosphin

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee
8370 Indication of lapse of patent is to be deleted