DE69535288D1 - Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren - Google Patents
Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimierenInfo
- Publication number
- DE69535288D1 DE69535288D1 DE69535288T DE69535288T DE69535288D1 DE 69535288 D1 DE69535288 D1 DE 69535288D1 DE 69535288 T DE69535288 T DE 69535288T DE 69535288 T DE69535288 T DE 69535288T DE 69535288 D1 DE69535288 D1 DE 69535288D1
- Authority
- DE
- Germany
- Prior art keywords
- inducing
- immune response
- recombinant vaccinia
- vaccinia viruses
- csf gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2033—IL-5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US242268 | 1981-03-10 | ||
US24226894A | 1994-05-13 | 1994-05-13 | |
PCT/US1995/005908 WO1995031105A1 (en) | 1994-05-13 | 1995-05-11 | A method of inducing an immune response using vaccinia virus recombinants |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69535288D1 true DE69535288D1 (de) | 2006-12-21 |
DE69535288T2 DE69535288T2 (de) | 2007-04-05 |
Family
ID=22914118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69535288T Expired - Lifetime DE69535288T2 (de) | 1994-05-13 | 1995-05-11 | Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0759695B1 (de) |
CA (1) | CA2190290C (de) |
DE (1) | DE69535288T2 (de) |
WO (1) | WO1995031105A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999029343A1 (en) | 1997-12-09 | 1999-06-17 | Thomas Jefferson University | Method of treating bladder cancer with wild type vaccinia virus |
EP2325321A1 (de) | 1999-05-28 | 2011-05-25 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Vacciniavirus-Vektor, in dem sowohl Wachstumsfaktor als auch Thymidinkinase deletiert sind |
EP1281767A3 (de) * | 2001-07-31 | 2003-05-28 | Aladar A. Szalay | Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren |
ATE420160T1 (de) | 2003-06-18 | 2009-01-15 | Genelux Corp | Modifizierte rekombinante vacciniaviren, verwendungen davon |
EP2426142A3 (de) | 2006-10-16 | 2012-06-13 | Genelux Corporation | Modifizierte Impfstoffvirusstämme zur Verwendung in einem Diagnose- und Therapieverfahren |
SG176619A1 (en) | 2009-07-10 | 2012-01-30 | Transgene Sa | Biomarker for selecting patients and related methods |
CN114262690A (zh) | 2011-04-15 | 2022-04-01 | 吉恩勒克斯公司 | 减毒的痘苗病毒的克隆毒株及其使用方法 |
WO2013004658A1 (en) | 2011-07-01 | 2013-01-10 | Transgene Sa | Formulations of 5-fluorocytosine and uses thereof. |
TWI690322B (zh) | 2012-10-02 | 2020-04-11 | 法商傳斯堅公司 | 含病毒的調配物及其使用 |
CN112618699A (zh) * | 2020-12-31 | 2021-04-09 | 深圳先进技术研究院 | 一种能够提供治疗有效量的白介素10的试剂及其抗肿瘤应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4675295A (en) * | 1981-10-28 | 1987-06-23 | Denki Kagaku Kogyo Kabushiki Kaisha | Process for producing subculturable lymphokine-producing human T cell hybridomas |
US5833975A (en) * | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
GB8508845D0 (en) * | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
FR2583429B1 (fr) * | 1985-06-18 | 1989-11-03 | Transgene Sa | Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u |
ZA875681B (en) * | 1986-08-01 | 1988-04-27 | Commw Scient Ind Res Org | Recombinant vaccine |
AU613583B2 (en) * | 1986-08-22 | 1991-08-08 | Transgene S.A. | Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity |
US5662896A (en) * | 1988-03-21 | 1997-09-02 | Chiron Viagene, Inc. | Compositions and methods for cancer immunotherapy |
ATE129746T1 (de) * | 1990-09-14 | 1995-11-15 | Univ Johns Hopkins | Verfahren und zusammensetzungen für gentherapie und stärkung des immunsystems. |
CA2051289C (en) * | 1990-09-14 | 2002-11-26 | Robert L. Martuza | Viral mediated destruction of neoplastic cells |
US6099846A (en) * | 1992-10-14 | 2000-08-08 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of B cell lymphoma and tumor resistance using idiotype/cytokine conjugates |
JPH08508641A (ja) * | 1993-03-16 | 1996-09-17 | ブリテイツシユ・テクノロジー・グループ・リミテツド | ウイルスタンパク質による免疫応答刺激 |
HUT73383A (en) * | 1993-03-19 | 1996-07-29 | Boehringer Sohn Ingelheim | Process for preparing cancer vaccines |
FR2710536B1 (fr) * | 1993-09-29 | 1995-12-22 | Transgene Sa | Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire. |
ZA942636B (en) * | 1994-04-06 | 1994-11-07 | Immunex Corp | Interleukin-15 |
EP0753581A1 (de) * | 1995-07-10 | 1997-01-15 | Immuno Ag | Verbesserte rekombinante eukaryotische zytoplasmatische Viren, Methode ihrer Herstellung und ihrer Verwendung als Impfstoffe |
-
1995
- 1995-05-11 CA CA2190290A patent/CA2190290C/en not_active Expired - Lifetime
- 1995-05-11 DE DE69535288T patent/DE69535288T2/de not_active Expired - Lifetime
- 1995-05-11 EP EP95919799A patent/EP0759695B1/de not_active Expired - Lifetime
- 1995-05-11 WO PCT/US1995/005908 patent/WO1995031105A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CA2190290A1 (en) | 1995-11-23 |
EP0759695A1 (de) | 1997-03-05 |
EP0759695A4 (de) | 2001-04-04 |
WO1995031105A1 (en) | 1995-11-23 |
EP0759695B1 (de) | 2006-11-08 |
DE69535288T2 (de) | 2007-04-05 |
CA2190290C (en) | 2011-07-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |