DE69535288D1 - Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren - Google Patents

Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren

Info

Publication number
DE69535288D1
DE69535288D1 DE69535288T DE69535288T DE69535288D1 DE 69535288 D1 DE69535288 D1 DE 69535288D1 DE 69535288 T DE69535288 T DE 69535288T DE 69535288 T DE69535288 T DE 69535288T DE 69535288 D1 DE69535288 D1 DE 69535288D1
Authority
DE
Germany
Prior art keywords
inducing
immune response
recombinant vaccinia
vaccinia viruses
csf gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535288T
Other languages
English (en)
Other versions
DE69535288T2 (de
Inventor
J Mastrangelo
C Lattime
David Berd
C Eisenlohr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Thomas Jefferson University
Original Assignee
Thomas Jefferson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomas Jefferson University filed Critical Thomas Jefferson University
Publication of DE69535288D1 publication Critical patent/DE69535288D1/de
Application granted granted Critical
Publication of DE69535288T2 publication Critical patent/DE69535288T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2026—IL-4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2033—IL-5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69535288T 1994-05-13 1995-05-11 Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren Expired - Lifetime DE69535288T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US242268 1981-03-10
US24226894A 1994-05-13 1994-05-13
PCT/US1995/005908 WO1995031105A1 (en) 1994-05-13 1995-05-11 A method of inducing an immune response using vaccinia virus recombinants

Publications (2)

Publication Number Publication Date
DE69535288D1 true DE69535288D1 (de) 2006-12-21
DE69535288T2 DE69535288T2 (de) 2007-04-05

Family

ID=22914118

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535288T Expired - Lifetime DE69535288T2 (de) 1994-05-13 1995-05-11 Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren

Country Status (4)

Country Link
EP (1) EP0759695B1 (de)
CA (1) CA2190290C (de)
DE (1) DE69535288T2 (de)
WO (1) WO1995031105A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029343A1 (en) 1997-12-09 1999-06-17 Thomas Jefferson University Method of treating bladder cancer with wild type vaccinia virus
EP2325321A1 (de) 1999-05-28 2011-05-25 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Vacciniavirus-Vektor, in dem sowohl Wachstumsfaktor als auch Thymidinkinase deletiert sind
EP1281767A3 (de) * 2001-07-31 2003-05-28 Aladar A. Szalay Lichtausstrahlende Mikroorganismen und Zellen für die Diagnose und Therapie von Tumoren
ATE420160T1 (de) 2003-06-18 2009-01-15 Genelux Corp Modifizierte rekombinante vacciniaviren, verwendungen davon
EP2426142A3 (de) 2006-10-16 2012-06-13 Genelux Corporation Modifizierte Impfstoffvirusstämme zur Verwendung in einem Diagnose- und Therapieverfahren
SG176619A1 (en) 2009-07-10 2012-01-30 Transgene Sa Biomarker for selecting patients and related methods
CN114262690A (zh) 2011-04-15 2022-04-01 吉恩勒克斯公司 减毒的痘苗病毒的克隆毒株及其使用方法
WO2013004658A1 (en) 2011-07-01 2013-01-10 Transgene Sa Formulations of 5-fluorocytosine and uses thereof.
TWI690322B (zh) 2012-10-02 2020-04-11 法商傳斯堅公司 含病毒的調配物及其使用
CN112618699A (zh) * 2020-12-31 2021-04-09 深圳先进技术研究院 一种能够提供治疗有效量的白介素10的试剂及其抗肿瘤应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675295A (en) * 1981-10-28 1987-06-23 Denki Kagaku Kogyo Kabushiki Kaisha Process for producing subculturable lymphokine-producing human T cell hybridomas
US5833975A (en) * 1989-03-08 1998-11-10 Virogenetics Corporation Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence
GB8508845D0 (en) * 1985-04-04 1985-05-09 Hoffmann La Roche Vaccinia dna
FR2583429B1 (fr) * 1985-06-18 1989-11-03 Transgene Sa Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u
ZA875681B (en) * 1986-08-01 1988-04-27 Commw Scient Ind Res Org Recombinant vaccine
AU613583B2 (en) * 1986-08-22 1991-08-08 Transgene S.A. Proteins and the method for preparing them, DNA sequences, antibodies and their application, poxviruses, transformed or infected cells, pharmaceutical compositions which are useful in the prevention of schistosomiasis and application by way of an agent possessing glutathione s-transferase activity
US5662896A (en) * 1988-03-21 1997-09-02 Chiron Viagene, Inc. Compositions and methods for cancer immunotherapy
ATE129746T1 (de) * 1990-09-14 1995-11-15 Univ Johns Hopkins Verfahren und zusammensetzungen für gentherapie und stärkung des immunsystems.
CA2051289C (en) * 1990-09-14 2002-11-26 Robert L. Martuza Viral mediated destruction of neoplastic cells
US6099846A (en) * 1992-10-14 2000-08-08 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of B cell lymphoma and tumor resistance using idiotype/cytokine conjugates
JPH08508641A (ja) * 1993-03-16 1996-09-17 ブリテイツシユ・テクノロジー・グループ・リミテツド ウイルスタンパク質による免疫応答刺激
HUT73383A (en) * 1993-03-19 1996-07-29 Boehringer Sohn Ingelheim Process for preparing cancer vaccines
FR2710536B1 (fr) * 1993-09-29 1995-12-22 Transgene Sa Usage anti-cancéreux d'un vecteur viral comportant un gène modulateur de la réponse immunitaire et/ou inflammatoire.
ZA942636B (en) * 1994-04-06 1994-11-07 Immunex Corp Interleukin-15
EP0753581A1 (de) * 1995-07-10 1997-01-15 Immuno Ag Verbesserte rekombinante eukaryotische zytoplasmatische Viren, Methode ihrer Herstellung und ihrer Verwendung als Impfstoffe

Also Published As

Publication number Publication date
CA2190290A1 (en) 1995-11-23
EP0759695A1 (de) 1997-03-05
EP0759695A4 (de) 2001-04-04
WO1995031105A1 (en) 1995-11-23
EP0759695B1 (de) 2006-11-08
DE69535288T2 (de) 2007-04-05
CA2190290C (en) 2011-07-05

Similar Documents

Publication Publication Date Title
DE3280246D1 (de) Cdna representierende rna-virensequenzen.
NO20003087D0 (no) Metode for Õ forsterke en immunrespons ved nukleinsyrevaksinasjon
IT9020063A0 (it) Vaccino di poxvirus ricombinante di herpesvirus
DE3688686D1 (de) Verfahren zur formung mehrschichtige gefaesse.
DE3768968D1 (de) Steuerungsverfahren fuer das fahrzeugverhalten.
DE3853088T2 (de) Rekombinantes Avipoxvirus.
KR970704468A (ko) 폴리에피토프 백신(polyepitope vaccines)
FI882508A0 (fi) Partiklar innehaollande ammoniumsalter eller andra kloreliminerande aemnen foer detergentkompositioner.
DE3484356D1 (de) Destillationsverfahren das bodenzusatzprodukte verwendet.
DE3850019D1 (de) Rekombinantes Avipoxvirus.
DE3881905D1 (de) Mittel fuer elektrophorese.
DE69535288D1 (de) Verfahren zur induzierung einer immunantwort mittels rekombinanten vaccinia-viren, die das gm-csf-gen exprimieren
DE3873173T2 (de) Vorrichtung fuer hf-induktionsheizung.
DE68921204T2 (de) Induktionsheizvorrichtung.
IT1242071B (it) Gel per la barba e metodo per prepararlo.
DE69133573D1 (de) Verfahren zur Typisierung von HLA-Klass-1-DNS mittels PCR-Amplifizierung
DE3778755D1 (de) Bestandteil fuer elektrophorese.
DE69002196D1 (de) Verfahren zur mikroverkapselung nach dem grenzflaechenpolymerisationsverfahren.
DK480685D0 (da) Dna-sekvenser, rekombinant-dna samt fremgangsmaader til fremstilling af antigener af plasmodium falciparum
DE3884455D1 (de) Verfahren zur herstellung einer gradientgel-membran fuer die elektrophorese.
DE3779846T2 (de) Giessverfahren fuer oberflaechen.
DK278682A (da) Fremgangsmaade til fremstilling af ralaxin ved rekombinant-dna-teknik
DE3679890D1 (de) Verfahren zur herstellung von mittels nitriddispersionen verstaerkten legierungen.
DE3767813D1 (de) Stranggussverfahren.
DE69021972T2 (de) Katalysator zur asymmetrischen Induktion.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition