DE69534402D1 - Apoptose-proteasen 3 und 4, ähnlich dem umwandlungsenzym für interleukin-1beta - Google Patents
Apoptose-proteasen 3 und 4, ähnlich dem umwandlungsenzym für interleukin-1betaInfo
- Publication number
- DE69534402D1 DE69534402D1 DE69534402T DE69534402T DE69534402D1 DE 69534402 D1 DE69534402 D1 DE 69534402D1 DE 69534402 T DE69534402 T DE 69534402T DE 69534402 T DE69534402 T DE 69534402T DE 69534402 D1 DE69534402 D1 DE 69534402D1
- Authority
- DE
- Germany
- Prior art keywords
- polypeptides
- interleukin
- 1beta
- similar
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
- C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/334,251 US6538121B1 (en) | 1994-11-01 | 1994-11-01 | Interleukin-1 β converting enzyme like apoptosis protease-3 and 4 |
US334251 | 1994-11-01 | ||
PCT/US1995/007235 WO1996013603A1 (en) | 1994-11-01 | 1995-06-06 | INTERLEUKIN-1 β CONVERTING ENZYME LIKE APOPTOSIS PROTEASE-3 AND 4 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69534402D1 true DE69534402D1 (de) | 2005-09-29 |
DE69534402T2 DE69534402T2 (de) | 2006-06-29 |
Family
ID=23306335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69534402T Expired - Fee Related DE69534402T2 (de) | 1994-11-01 | 1995-06-06 | Apoptose-proteasen 3 und 4, ähnlich dem umwandlungsenzym für interleukin-1beta |
Country Status (8)
Country | Link |
---|---|
US (5) | US6538121B1 (de) |
EP (1) | EP0792370B1 (de) |
JP (2) | JP3675828B2 (de) |
AT (1) | ATE302850T1 (de) |
AU (1) | AU2768895A (de) |
DE (1) | DE69534402T2 (de) |
ES (1) | ES2247591T3 (de) |
WO (1) | WO1996013603A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835555B1 (en) * | 1994-11-01 | 2004-12-28 | Human Genome Sciences, Inc. | Interleukin-1 β converting enzyme like apoptosis protease-3 and 4 |
US6538121B1 (en) * | 1994-11-01 | 2003-03-25 | Human Genome Sciences, Inc. | Interleukin-1 β converting enzyme like apoptosis protease-3 and 4 |
IL114615A0 (en) | 1995-07-16 | 1995-11-27 | Yeda Res & Dev | Modulators of the function of fas receptors and other proteins |
US7097972B1 (en) * | 1995-02-13 | 2006-08-29 | Regents Of The University Of Michigan | Method and composition for regulating apoptosis |
CA2218679A1 (en) * | 1995-04-21 | 1996-10-24 | Merck & Co., Inc. | Apopain |
US6399327B1 (en) | 1995-07-16 | 2002-06-04 | Yeda Research And Development Co. Ltd. | Modulators of the function of FAS receptors and other proteins |
AU720077B2 (en) * | 1995-11-03 | 2000-05-25 | Vertex Pharmaceuticals Incorporated | DNA sequences encoding CMH-1, a cysteine protease involved in apoptosis |
US6462175B1 (en) * | 1995-11-13 | 2002-10-08 | Thomas Jefferson University | Mch3, a novel apoptotic protease, nucleic acids encoding and methods of use |
EP0842665A3 (de) * | 1996-11-14 | 2002-12-18 | Smithkline Beecham Corporation | Interleukin-1-beta-konvertierendes-Enzym-ähnliche Apoptosisproteasen und ihre Agonisten |
US6340740B1 (en) | 1997-08-26 | 2002-01-22 | Thomas Jefferson University | Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use |
US6432628B1 (en) | 1997-08-26 | 2002-08-13 | Thomas Jefferson University | Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use |
AU763721B2 (en) | 1998-07-17 | 2003-07-31 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | New caspase homologue |
WO2002022640A1 (en) * | 2000-09-11 | 2002-03-21 | Isis Pharmaceuticals, Inc. | Antisense modulation of caspase 7 expression |
US20030199000A1 (en) * | 2001-08-20 | 2003-10-23 | Valkirs Gunars E. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
US20040219509A1 (en) * | 2001-08-20 | 2004-11-04 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
JP2005522669A (ja) * | 2001-08-20 | 2005-07-28 | バイオサイト インコーポレイテッド | 卒中および脳損傷の診断マーカーおよびその使用方法 |
US20040209307A1 (en) * | 2001-08-20 | 2004-10-21 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
WO2006035445A2 (en) * | 2004-09-29 | 2006-04-06 | Insight Biopharmaceuticals Ltd. | Methods of treating pathologies associated with oxidative stress |
DK3903829T3 (da) | 2009-02-13 | 2023-06-26 | Immunomedics Inc | Immunkonjugater med en intracellulær spaltelig binding |
EP3009455A1 (de) | 2009-09-16 | 2016-04-20 | Immunomedics Inc. | Klasse-i-anti-cea-antikörper und verwendungen davon |
IN2012DN03354A (de) | 2009-12-02 | 2015-10-23 | Immunomedics Inc | |
EP2704751B1 (de) | 2011-05-02 | 2019-04-17 | Immunomedics, Inc. | Ultrafiltrationskonzentration ausgewählter allotypen-antikörper für kleinvolumige verabreichung |
EP2885002A4 (de) | 2012-08-14 | 2016-04-20 | Ibc Pharmaceuticals Inc | Umleitung t-zell-bispezifischer antikörper zur behandlung von krankheiten |
CA3177936A1 (en) | 2012-12-13 | 2014-06-19 | Immunomedics, Inc. | Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity |
CN106132436B (zh) | 2014-02-21 | 2021-06-15 | Ibc药品公司 | 通过诱导对trop-2表达细胞的免疫应答的疾病疗法 |
US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
US9580495B2 (en) | 2014-06-24 | 2017-02-28 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
CN106999517A (zh) | 2014-10-07 | 2017-08-01 | 免疫医疗公司 | 抗体‑药物缀合物的新辅助剂用途 |
EP3286224A4 (de) | 2015-04-22 | 2018-11-14 | Immunomedics, Inc. | Isolierung, detektion, diagnose und/oder charakterisierung von zirkulierenden trop-2-positiven krebszellen |
PL3313443T3 (pl) | 2015-06-25 | 2023-11-06 | Immunomedics, Inc. | Łączenie przeciwciał anty-hla-dr lub anty-trop-2 z inhibitorami mikrotubuli, inhibitorami parp, 5 inhibitorami kinazy brutona lub inhibitorami 3-kinazy fosfoinozytydu istotnie poprawia wynik terapeutyczny nowotworu |
SI3316885T1 (sl) | 2015-07-01 | 2021-09-30 | Immunomedics, Inc. | Imunokonjugati protitelo-SN-38 z linkerjem CL2A |
KR20220124817A (ko) | 2017-08-07 | 2022-09-14 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 안전한 세포 치료제를 생성하기 위한 플랫폼 |
US10960071B2 (en) | 2017-08-07 | 2021-03-30 | The Regents Of The University Of California | Platform for generating safe cell therapeutics |
WO2022239720A1 (ja) | 2021-05-10 | 2022-11-17 | 公益財団法人川崎市産業振興財団 | 抗原への結合親和性を低減させた抗体 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260203A (en) * | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
EP0533226A3 (en) | 1991-08-16 | 1993-08-18 | Merck & Co. Inc. | Novel chromophore containing compounds |
US5552536A (en) * | 1994-04-08 | 1996-09-03 | Merck Frosst Canada, Inc. | DNA encoding precursor of interleukin-1 beta converting enzyme - related cysteine proteinase III (ice rel-III) |
US6538121B1 (en) * | 1994-11-01 | 2003-03-25 | Human Genome Sciences, Inc. | Interleukin-1 β converting enzyme like apoptosis protease-3 and 4 |
US6835555B1 (en) * | 1994-11-01 | 2004-12-28 | Human Genome Sciences, Inc. | Interleukin-1 β converting enzyme like apoptosis protease-3 and 4 |
CA2218679A1 (en) * | 1995-04-21 | 1996-10-24 | Merck & Co., Inc. | Apopain |
-
1994
- 1994-11-01 US US08/334,251 patent/US6538121B1/en not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/462,969 patent/US6087150A/en not_active Expired - Lifetime
- 1995-06-06 EP EP95922997A patent/EP0792370B1/de not_active Expired - Lifetime
- 1995-06-06 WO PCT/US1995/007235 patent/WO1996013603A1/en active IP Right Grant
- 1995-06-06 AT AT95922997T patent/ATE302850T1/de not_active IP Right Cessation
- 1995-06-06 AU AU27688/95A patent/AU2768895A/en not_active Abandoned
- 1995-06-06 DE DE69534402T patent/DE69534402T2/de not_active Expired - Fee Related
- 1995-06-06 ES ES95922997T patent/ES2247591T3/es not_active Expired - Lifetime
- 1995-06-06 JP JP51452796A patent/JP3675828B2/ja not_active Expired - Fee Related
-
1998
- 1998-07-28 US US09/124,934 patent/US6495519B1/en not_active Expired - Lifetime
-
2001
- 2001-07-02 US US09/895,263 patent/US6733981B2/en not_active Expired - Fee Related
-
2002
- 2002-04-23 JP JP2002121377A patent/JP2003009889A/ja not_active Withdrawn
-
2008
- 2008-08-25 US US12/197,977 patent/US20090142329A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0792370A1 (de) | 1997-09-03 |
US6495519B1 (en) | 2002-12-17 |
US20020076793A1 (en) | 2002-06-20 |
US6087150A (en) | 2000-07-11 |
US20090142329A1 (en) | 2009-06-04 |
DE69534402T2 (de) | 2006-06-29 |
AU2768895A (en) | 1996-05-23 |
ATE302850T1 (de) | 2005-09-15 |
ES2247591T3 (es) | 2006-03-01 |
US6733981B2 (en) | 2004-05-11 |
WO1996013603A1 (en) | 1996-05-09 |
US6538121B1 (en) | 2003-03-25 |
EP0792370A4 (de) | 1997-10-22 |
JPH11503901A (ja) | 1999-04-06 |
JP2003009889A (ja) | 2003-01-14 |
EP0792370B1 (de) | 2005-08-24 |
JP3675828B2 (ja) | 2005-07-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |