DE69534039D1 - Verwendung von valin zur herstellung eines medikaments zur leberregeneration - Google Patents
Verwendung von valin zur herstellung eines medikaments zur leberregenerationInfo
- Publication number
- DE69534039D1 DE69534039D1 DE69534039T DE69534039T DE69534039D1 DE 69534039 D1 DE69534039 D1 DE 69534039D1 DE 69534039 T DE69534039 T DE 69534039T DE 69534039 T DE69534039 T DE 69534039T DE 69534039 D1 DE69534039 D1 DE 69534039D1
- Authority
- DE
- Germany
- Prior art keywords
- liver
- liver regeneration
- regeneration
- cancer
- valin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000004185 liver Anatomy 0.000 title abstract 4
- 230000008929 regeneration Effects 0.000 title abstract 4
- 238000011069 regeneration method Methods 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 201000007270 liver cancer Diseases 0.000 abstract 2
- 208000019423 liver disease Diseases 0.000 abstract 2
- 208000014018 liver neoplasm Diseases 0.000 abstract 2
- 208000004930 Fatty Liver Diseases 0.000 abstract 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 abstract 1
- 206010019708 Hepatic steatosis Diseases 0.000 abstract 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000010706 fatty liver disease Diseases 0.000 abstract 1
- 201000010175 gallbladder cancer Diseases 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000003908 liver function Effects 0.000 abstract 1
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 239000004474 valine Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14199894 | 1994-06-23 | ||
| JP14199894 | 1994-06-23 | ||
| PCT/JP1995/001136 WO1996000059A1 (fr) | 1994-06-23 | 1995-06-07 | Agent therapeutique de regenerescence hepatique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69534039D1 true DE69534039D1 (de) | 2005-04-07 |
| DE69534039T2 DE69534039T2 (de) | 2005-12-29 |
Family
ID=15305015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69534039T Expired - Fee Related DE69534039T2 (de) | 1994-06-23 | 1995-06-07 | Verwendung von valin zur herstellung eines medikaments zur leberregeneration |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5916921A (de) |
| EP (1) | EP0769295B1 (de) |
| KR (1) | KR100322404B1 (de) |
| CN (1) | CN1073844C (de) |
| AT (1) | ATE289809T1 (de) |
| AU (1) | AU2629895A (de) |
| CA (1) | CA2193363C (de) |
| DE (1) | DE69534039T2 (de) |
| ES (1) | ES2238680T3 (de) |
| WO (1) | WO1996000059A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW473387B (en) * | 1997-09-30 | 2002-01-21 | Chugai Pharmaceutical Co Ltd | Pharmaceutical or food compositions for treating hepatic diseases or improving liver functions |
| US20040022827A1 (en) * | 1997-09-30 | 2004-02-05 | Chugai Seiyaku Kabusiki Kaisha | Remedy for hepatopathy |
| WO2001013912A1 (fr) * | 1999-08-23 | 2001-03-01 | Chugai Seiyaku Kabushiki Kaisha | Medicaments destines a la regeneration d'un foie transplante |
| CA2413149A1 (en) | 2000-06-14 | 2001-12-20 | Medarex, Inc. | Prodrug compounds with isoleucine |
| US6864242B2 (en) * | 2001-03-05 | 2005-03-08 | Stephen P. Ernest | Enteral formulation |
| WO2003063853A1 (fr) * | 2002-01-31 | 2003-08-07 | Chugai Seiyaku Kabushiki Kaisha | Compositions de reduction de la graisse mesenterique |
| CN101720222B (zh) | 2007-06-21 | 2016-09-07 | 学校法人城西大学 | 具有促进肝细胞增殖作用的药物 |
| KR100943577B1 (ko) | 2009-08-28 | 2010-02-23 | 서울대학교산학협력단 | 베타인을 함유하는 부분적으로 절제된 간의 재생 촉진용 조성물 |
| FR2989032B1 (fr) | 2012-04-05 | 2015-04-10 | Michelin & Cie | Pneumatique et ensemble pneumatique-roue a mobilite etendue |
| FR3002490B1 (fr) | 2013-02-25 | 2015-03-27 | Michelin & Cie | Pneumatique auto-obturant comportant une armature de flanc supplementaire |
| RU2643591C1 (ru) * | 2017-03-30 | 2018-02-02 | Александр Иванович Леляк | Средство для стимуляции регенерации ткани печени при парентеральном введении и способ стимуляции регенерации ткани печени на его основе |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2750159C3 (de) * | 1977-11-09 | 1980-05-22 | Lentia Gmbh, Chem. U. Pharm. Erzeugnisse - Industriebedarf, 8000 Muenchen | Infusionslösung zur Behandlung von hepatischer Encephalopathie und ein Verfahren zu deren Herstellung |
| JPS58126767A (ja) * | 1982-01-22 | 1983-07-28 | Ajinomoto Co Inc | 肝臓病患者用栄養組成物 |
| JPS61186320A (ja) * | 1985-02-12 | 1986-08-20 | Morishita Seiyaku Kk | アミノ酸製剤 |
-
1995
- 1995-06-07 WO PCT/JP1995/001136 patent/WO1996000059A1/ja active IP Right Grant
- 1995-06-07 ES ES95921124T patent/ES2238680T3/es not_active Expired - Lifetime
- 1995-06-07 KR KR1019960707366A patent/KR100322404B1/ko not_active IP Right Cessation
- 1995-06-07 CN CN95194285A patent/CN1073844C/zh not_active Expired - Fee Related
- 1995-06-07 DE DE69534039T patent/DE69534039T2/de not_active Expired - Fee Related
- 1995-06-07 AU AU26298/95A patent/AU2629895A/en not_active Abandoned
- 1995-06-07 CA CA002193363A patent/CA2193363C/en not_active Expired - Fee Related
- 1995-06-07 EP EP95921124A patent/EP0769295B1/de not_active Expired - Lifetime
- 1995-06-07 US US08/750,814 patent/US5916921A/en not_active Expired - Fee Related
- 1995-06-07 AT AT95921124T patent/ATE289809T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0769295A1 (de) | 1997-04-23 |
| CN1154064A (zh) | 1997-07-09 |
| WO1996000059A1 (fr) | 1996-01-04 |
| AU2629895A (en) | 1996-01-19 |
| CA2193363C (en) | 2004-07-13 |
| KR970703763A (ko) | 1997-08-09 |
| CN1073844C (zh) | 2001-10-31 |
| US5916921A (en) | 1999-06-29 |
| KR100322404B1 (ko) | 2002-05-09 |
| EP0769295A4 (de) | 1999-11-10 |
| ATE289809T1 (de) | 2005-03-15 |
| CA2193363A1 (en) | 1996-01-04 |
| ES2238680T3 (es) | 2005-09-01 |
| DE69534039T2 (de) | 2005-12-29 |
| EP0769295B1 (de) | 2005-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |