DE69533102D1 - Analog von haemophilus hin47 mit verminderter protease aktivität - Google Patents

Analog von haemophilus hin47 mit verminderter protease aktivität

Info

Publication number
DE69533102D1
DE69533102D1 DE69533102T DE69533102T DE69533102D1 DE 69533102 D1 DE69533102 D1 DE 69533102D1 DE 69533102 T DE69533102 T DE 69533102T DE 69533102 T DE69533102 T DE 69533102T DE 69533102 D1 DE69533102 D1 DE 69533102D1
Authority
DE
Germany
Prior art keywords
hin47
protein
analog
nucleic acid
haemophilus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69533102T
Other languages
English (en)
Other versions
DE69533102T2 (de
Inventor
M Loosmore
Yan-Ping Yang
Pele Chong
P Oomen
H Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur Ltd
Original Assignee
Aventis Pasteur Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27402970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69533102(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/278,091 external-priority patent/US5506139A/en
Priority claimed from US08/296,149 external-priority patent/US5939297A/en
Application filed by Aventis Pasteur Ltd filed Critical Aventis Pasteur Ltd
Publication of DE69533102D1 publication Critical patent/DE69533102D1/de
Application granted granted Critical
Publication of DE69533102T2 publication Critical patent/DE69533102T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69533102T 1994-07-21 1995-07-21 Analog von haemophilus hin47 mit verminderter protease aktivität Expired - Lifetime DE69533102T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US278091 1994-07-21
US08/278,091 US5506139A (en) 1994-07-21 1994-07-21 Analog of haemophilus Hin47 with reduced protease activity
US296149 1994-08-26
US08/296,149 US5939297A (en) 1994-07-21 1994-08-26 Analog of haemophilus HIN47 with reduced protease activity
US487167 1995-06-07
US08/487,167 US5869302A (en) 1994-07-21 1995-06-07 Analog of haemophilus hin47 with reduced protease activity
PCT/CA1995/000434 WO1996003506A2 (en) 1994-07-21 1995-07-21 Analog of haemophilus hin47 with reduced protease activity

Publications (2)

Publication Number Publication Date
DE69533102D1 true DE69533102D1 (de) 2004-07-08
DE69533102T2 DE69533102T2 (de) 2005-06-02

Family

ID=27402970

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533102T Expired - Lifetime DE69533102T2 (de) 1994-07-21 1995-07-21 Analog von haemophilus hin47 mit verminderter protease aktivität

Country Status (8)

Country Link
US (3) US6020183A (de)
EP (1) EP0729513B1 (de)
AT (1) ATE268384T1 (de)
BR (1) BR9506272B8 (de)
CA (1) CA2171611C (de)
DE (1) DE69533102T2 (de)
NZ (1) NZ291750A (de)
WO (1) WO1996003506A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6147057A (en) * 1994-07-21 2000-11-14 Connaught Laboratories Limited Analog of Haemophilus Hin47 with reduced protease activity
KR970007351A (ko) * 1995-07-24 1997-02-01 미츠이 마코토 활성화된 인자의 정량방법
US6974581B1 (en) * 1998-12-15 2005-12-13 Aventis Pasteur Limited Multi-component vaccine comprising at least two antigens from haemophilus influenzae to protect against disease
US6391313B1 (en) 1999-07-15 2002-05-21 Aventis Pasteur Limited Multi-component vaccine to protect against disease caused by Haemophilus influenzae and Moraxella catarrhalis
US7015033B1 (en) * 2000-05-25 2006-03-21 Aventis Pasteur Limited Co-expression of recombination proteins
US6342769B1 (en) * 2000-11-07 2002-01-29 Orville J. Birkestrand Electronic throttle/brake control system for monitorized wheel hub
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
US8241623B1 (en) 2009-02-09 2012-08-14 David Bermudes Protease sensitivity expression system
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
KR102578256B1 (ko) * 2016-08-11 2023-09-15 리플리겐 코포레이션 친화성 크로마토그래피를 위한 알칼리 안정 fc-결합 단백질
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EP3665189A1 (de) 2017-08-07 2020-06-17 Repligen Corporation Fc-bindungsproteine mit cystein in der c-terminalen helikalen region

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3330935B2 (ja) * 1990-12-21 2002-10-07 アンテックス バイオロジックス，インコーポレーテッド ヘモフィルス・インフルエンザ用アドヘシン−オリゴ糖複合体ワクチン
JPH06504670A (ja) * 1990-12-21 1994-06-02 マイクロカーブ　インコーポレイティド 微生物に関する脂質レセプター及び対応の付着因子、付着因子をコードするｄｎａ配列、並びにそれらの利用方法
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
GB9224584D0 (en) * 1992-11-23 1993-01-13 Connaught Lab Use of outer membrane protein d15 and its peptides as vaccine against haempohilus influenzae diseases
US5939297A (en) * 1994-07-21 1999-08-17 Connaught Laboratories Limited Analog of haemophilus HIN47 with reduced protease activity

Also Published As

Publication number Publication date
WO1996003506A3 (en) 1996-03-07
EP0729513B1 (de) 2004-06-02
BR9506272B1 (pt) 2010-02-23
US6114125A (en) 2000-09-05
US6020183A (en) 2000-02-01
EP0729513A1 (de) 1996-09-04
ATE268384T1 (de) 2004-06-15
NZ291750A (en) 1997-10-24
WO1996003506A2 (en) 1996-02-08
AU3337695A (en) 1996-02-22
CA2171611A1 (en) 1996-02-08
DE69533102T2 (de) 2005-06-02
BR9506272B8 (pt) 2014-08-05
CA2171611C (en) 2001-05-29
BR9506272A (pt) 1997-08-12
US6025342A (en) 2000-02-15
AU687619B2 (en) 1998-02-26
MX9601065A (es) 1997-12-31

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