DE69532993D1 - Vorrichtung zum perkutanen messen des sauerstoffgehaltes mittels beobachtung der phosphoreszenz - Google Patents
Vorrichtung zum perkutanen messen des sauerstoffgehaltes mittels beobachtung der phosphoreszenzInfo
- Publication number
- DE69532993D1 DE69532993D1 DE69532993T DE69532993T DE69532993D1 DE 69532993 D1 DE69532993 D1 DE 69532993D1 DE 69532993 T DE69532993 T DE 69532993T DE 69532993 T DE69532993 T DE 69532993T DE 69532993 D1 DE69532993 D1 DE 69532993D1
- Authority
- DE
- Germany
- Prior art keywords
- probe
- phosphorescence
- measuring
- percutanically
- oxygen content
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 3
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- 239000001301 oxygen Substances 0.000 title abstract 3
- 239000000523 sample Substances 0.000 abstract 4
- 238000010438 heat treatment Methods 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000005284 excitation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000010791 quenching Methods 0.000 abstract 1
- 230000000171 quenching effect Effects 0.000 abstract 1
- 230000000287 tissue oxygenation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1491—Heated applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/14—Coupling media or elements to improve sensor contact with skin or tissue
- A61B2562/146—Coupling media or elements to improve sensor contact with skin or tissue for optical coupling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US278880 | 1994-07-22 | ||
US08/278,880 US5593899A (en) | 1993-02-25 | 1994-07-22 | Device and method for measuring tissue oxygenation through the skin using oxygen dependent quenching of phosphorescence |
PCT/US1995/009363 WO1996003074A1 (en) | 1994-07-22 | 1995-07-24 | Device and method for measuring tissue oxygenation through the skin using oxygen dependent quenching of phosphorescence |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69532993D1 true DE69532993D1 (de) | 2004-06-09 |
DE69532993T2 DE69532993T2 (de) | 2005-04-07 |
Family
ID=23066768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69532993T Expired - Fee Related DE69532993T2 (de) | 1994-07-22 | 1995-07-24 | Vorrichtung zum perkutanen messen des sauerstoffgehaltes mittels beobachtung der phosphoreszenz |
Country Status (7)
Country | Link |
---|---|
US (1) | US5593899A (de) |
EP (1) | EP0772416B1 (de) |
AT (1) | ATE265822T1 (de) |
AU (1) | AU711817B2 (de) |
CA (1) | CA2195532C (de) |
DE (1) | DE69532993T2 (de) |
WO (1) | WO1996003074A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6002954A (en) * | 1995-11-22 | 1999-12-14 | The Regents Of The University Of California | Detection of biological molecules using boronate-based chemical amplification and optical sensors |
ATE278801T1 (de) | 1995-11-22 | 2004-10-15 | Medtronic Minimed Inc | Detektion von biologischen molekülen unter verwendung von chemischer amplifikation und optischem sensor |
WO1998022820A1 (en) | 1996-11-21 | 1998-05-28 | Lawrence Livermore National Laboratory | Detection of biological molecules using boronate-based chemical amplification and optical sensors |
US6274086B1 (en) | 1996-12-16 | 2001-08-14 | The Trustees Of The University Of Pennsylvania | Apparatus for non-invasive imaging oxygen distribution in multi-dimensions |
DE69918285T2 (de) | 1998-04-24 | 2005-08-18 | Lightouch Medical, Inc. | Gerät und verfahren zur thermischen modulation von gewebe |
US6389306B1 (en) | 1998-04-24 | 2002-05-14 | Lightouch Medical, Inc. | Method for determining lipid and protein content of tissue |
US6352502B1 (en) | 1998-12-03 | 2002-03-05 | Lightouch Medical, Inc. | Methods for obtaining enhanced spectroscopic information from living tissue, noninvasive assessment of skin condition and detection of skin abnormalities |
US6503478B2 (en) | 1999-01-13 | 2003-01-07 | Lightouch Medical, Inc. | Chemically specific imaging of tissue |
DE59900583D1 (de) | 1999-03-29 | 2002-01-31 | Hoffmann La Roche | Vorrichtung zur quantitativen Bestimmung der örtlichen Verteilung einer Messgrösse |
US6673625B2 (en) | 1999-09-15 | 2004-01-06 | The Regents Of The University Of California | Saccharide sensing molecules having enhanced fluorescent properties |
US6682938B1 (en) | 1999-09-15 | 2004-01-27 | The Regents Of The University Of California | Glucose sensing molecules having selected fluorescent properties |
AT409451B (de) * | 1999-12-14 | 2002-08-26 | Hoffmann La Roche | Vorrichtung zur bestimmung der örtlichen verteilung einer messgrösse |
US20010034479A1 (en) * | 2000-04-19 | 2001-10-25 | Ring Lawrence S. | Optically based transcutaneous blood gas sensor |
AU2002359257A1 (en) | 2001-10-15 | 2003-04-28 | University Of Massachusetts | Tissue oxygen measurement system |
SE523698C2 (sv) * | 2002-04-26 | 2004-05-11 | Gert Nilsson | Metod och anordning för icke-invasiv mätning av transkutan syreupptagning |
DE102005036410A1 (de) * | 2005-07-29 | 2007-02-01 | Biocam Gmbh | Verfahren zur Ermittlung der Sauerstoffpartialdruckverteilung in zumindest einem Gewebeflächenabschnitt, insbesondere Hautgewebeflächenabschnitt |
EP1973503B1 (de) | 2006-01-04 | 2013-09-25 | The Trustees of the University of Pennsylvania | Sauerstoffsensor zur internen überwachung von gewebesauerstoff in vivo |
US9339191B2 (en) * | 2008-07-08 | 2016-05-17 | Hitachi, Ltd. | Optical measurement apparatus |
JP5665305B2 (ja) * | 2008-12-25 | 2015-02-04 | キヤノン株式会社 | 分析装置 |
US9737213B1 (en) * | 2009-03-24 | 2017-08-22 | Vioptix, Inc. | Using an oximeter probe to detect intestinal ischemia |
US8647876B2 (en) * | 2010-03-31 | 2014-02-11 | Fujifilm Corporation | Oxygen permeability measuring apparatus and method, and defect inspection apparatus and method |
US20120184831A1 (en) * | 2011-01-18 | 2012-07-19 | Radiation Monitoring Devices, Inc. | Systems, devices and methods for monitoring hemodynamics |
JP6457950B2 (ja) * | 2013-01-16 | 2019-01-23 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | ガス濃度を決定するためのセンサ |
EP4079242A1 (de) * | 2013-03-19 | 2022-10-26 | Surgisense Corporation | Vorrichtung, systeme und verfahren zur bestimmung der sauerstoffanreicherung von gewebe |
WO2015154094A1 (en) * | 2014-04-05 | 2015-10-08 | Zand Jason M | Apparatus, systems, and methods for mapping of tissue oxygenation |
DE102015104312A1 (de) * | 2015-03-23 | 2016-09-29 | Osram Opto Semiconductors Gmbh | Sensor zur Erfassung einer biometrischen Funktion |
JP2017181211A (ja) * | 2016-03-29 | 2017-10-05 | 株式会社カテラ | 光学的経皮酸素センサ及びこれを用いた経皮酸素濃度測定装置 |
US11406297B2 (en) | 2016-05-13 | 2022-08-09 | The General Hospital Corporation | Systems and methods of optical transcutaneous oxygenation monitoring |
KR102574086B1 (ko) * | 2018-02-21 | 2023-09-04 | 삼성전자주식회사 | 라만 프로브 |
US11467151B1 (en) * | 2021-12-23 | 2022-10-11 | United Arab Emirates University | Phosphorescence oxygen analyzer and uses thereof |
WO2023159029A1 (en) * | 2022-02-15 | 2023-08-24 | West Pharmaceutical Services, Inc. | Patch for sensing a physiological response |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2358992A (en) * | 1941-06-28 | 1944-09-26 | Glenn A Millikan | Oxygen meter |
US4041932A (en) * | 1975-02-06 | 1977-08-16 | Fostick Moshe A | Method for monitoring blood gas tension and pH from outside the body |
US4259963A (en) * | 1979-07-03 | 1981-04-07 | Albert Huch | Multi-purpose transducer for transcutaneous blood measurements |
CA1261717A (en) * | 1982-12-23 | 1989-09-26 | John R. Bacon | Method and apparatus for oxygen determination |
US5127405A (en) * | 1990-02-16 | 1992-07-07 | The Boc Group, Inc. | Biomedical fiber optic probe with frequency domain signal processing |
US6362175B1 (en) * | 1991-09-20 | 2002-03-26 | The Trustees Of The University Of Pennsylvania | Porphyrin compounds for imaging tissue oxygen |
US5304495A (en) * | 1992-12-29 | 1994-04-19 | Abbott Laboratories | Method for determining flush interference in measurement of chemical and physical parameters with indwelling probe |
-
1994
- 1994-07-22 US US08/278,880 patent/US5593899A/en not_active Expired - Lifetime
-
1995
- 1995-07-24 AU AU31450/95A patent/AU711817B2/en not_active Ceased
- 1995-07-24 CA CA002195532A patent/CA2195532C/en not_active Expired - Fee Related
- 1995-07-24 WO PCT/US1995/009363 patent/WO1996003074A1/en active IP Right Grant
- 1995-07-24 AT AT95927411T patent/ATE265822T1/de not_active IP Right Cessation
- 1995-07-24 EP EP95927411A patent/EP0772416B1/de not_active Expired - Lifetime
- 1995-07-24 DE DE69532993T patent/DE69532993T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0772416B1 (de) | 2004-05-06 |
EP0772416A1 (de) | 1997-05-14 |
CA2195532A1 (en) | 1996-02-08 |
AU711817B2 (en) | 1999-10-21 |
ATE265822T1 (de) | 2004-05-15 |
US5593899A (en) | 1997-01-14 |
WO1996003074A1 (en) | 1996-02-08 |
DE69532993T2 (de) | 2005-04-07 |
EP0772416A4 (de) | 1998-12-16 |
AU3145095A (en) | 1996-02-22 |
CA2195532C (en) | 2005-06-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |