DE69524393D1 - Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen durch die Absetzung von Arzenei/Zyklodextrin Komplexe auf inerte oder aktive Kerne - Google Patents
Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen durch die Absetzung von Arzenei/Zyklodextrin Komplexe auf inerte oder aktive KerneInfo
- Publication number
- DE69524393D1 DE69524393D1 DE69524393T DE69524393T DE69524393D1 DE 69524393 D1 DE69524393 D1 DE 69524393D1 DE 69524393 T DE69524393 T DE 69524393T DE 69524393 T DE69524393 T DE 69524393T DE 69524393 D1 DE69524393 D1 DE 69524393D1
- Authority
- DE
- Germany
- Prior art keywords
- inert
- solution
- deposition
- pharmaceutical compositions
- active cores
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical class O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 title abstract 3
- 230000008021 deposition Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000007791 liquid phase Substances 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- 239000000725 suspension Substances 0.000 abstract 3
- 229920000858 Cyclodextrin Polymers 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 229920000642 polymer Polymers 0.000 abstract 2
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011877 solvent mixture Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95670004A EP0745381B1 (de) | 1995-05-29 | 1995-05-29 | Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen durch die Absetzung von Arzenei/Zyklodextrin Komplexe auf inerte oder aktive Kerne |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69524393D1 true DE69524393D1 (de) | 2002-01-17 |
| DE69524393T2 DE69524393T2 (de) | 2002-09-19 |
Family
ID=8221680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69524393T Expired - Fee Related DE69524393T2 (de) | 1995-05-29 | 1995-05-29 | Verfahren zur Herstellung von pharmazeutischen Zusammensetzungen durch die Absetzung von Arzenei/Zyklodextrin Komplexe auf inerte oder aktive Kerne |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0745381B1 (de) |
| AT (1) | ATE209904T1 (de) |
| DE (1) | DE69524393T2 (de) |
| ES (1) | ES2169114T3 (de) |
| PT (1) | PT745381E (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999061062A1 (en) * | 1998-05-29 | 1999-12-02 | Massachusetts Institute Of Technology | Cyclodextrin complexes |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0241806A1 (de) * | 1986-04-14 | 1987-10-21 | Fujisawa Pharmaceutical Co., Ltd. | Transdermale Zubereitungen mit verzögerter Freisetzung |
-
1995
- 1995-05-29 AT AT95670004T patent/ATE209904T1/de not_active IP Right Cessation
- 1995-05-29 PT PT95670004T patent/PT745381E/pt unknown
- 1995-05-29 DE DE69524393T patent/DE69524393T2/de not_active Expired - Fee Related
- 1995-05-29 ES ES95670004T patent/ES2169114T3/es not_active Expired - Lifetime
- 1995-05-29 EP EP95670004A patent/EP0745381B1/de not_active Revoked
Also Published As
| Publication number | Publication date |
|---|---|
| PT745381E (pt) | 2002-05-31 |
| EP0745381B1 (de) | 2001-12-05 |
| EP0745381A1 (de) | 1996-12-04 |
| ES2169114T3 (es) | 2002-07-01 |
| DE69524393T2 (de) | 2002-09-19 |
| ATE209904T1 (de) | 2001-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8363 | Opposition against the patent | ||
| 8339 | Ceased/non-payment of the annual fee |