DE69511544D1 - Amidderivate und ihre therapeutische verwendung - Google Patents

Amidderivate und ihre therapeutische verwendung

Info

Publication number
DE69511544D1
DE69511544D1 DE69511544T DE69511544T DE69511544D1 DE 69511544 D1 DE69511544 D1 DE 69511544D1 DE 69511544 T DE69511544 T DE 69511544T DE 69511544 T DE69511544 T DE 69511544T DE 69511544 D1 DE69511544 D1 DE 69511544D1
Authority
DE
Germany
Prior art keywords
pct
date nov
fluoro
sec
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69511544T
Other languages
English (en)
Other versions
DE69511544T2 (de
Inventor
David Musso
James Kelley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE69511544D1 publication Critical patent/DE69511544D1/de
Application granted granted Critical
Publication of DE69511544T2 publication Critical patent/DE69511544T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/64—Acyl halides
    • C07C57/76—Acyl halides containing halogen outside the carbonyl halide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
DE69511544T 1994-05-10 1995-05-09 Amidderivate und ihre therapeutische verwendung Expired - Fee Related DE69511544T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94303350 1994-05-10
PCT/GB1995/001040 WO1995030645A1 (en) 1994-05-10 1995-05-09 Amide derivatives and their therapeutic use

Publications (2)

Publication Number Publication Date
DE69511544D1 true DE69511544D1 (de) 1999-09-23
DE69511544T2 DE69511544T2 (de) 1999-12-23

Family

ID=8217701

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69511544T Expired - Fee Related DE69511544T2 (de) 1994-05-10 1995-05-09 Amidderivate und ihre therapeutische verwendung

Country Status (26)

Country Link
US (1) US5708033A (de)
EP (1) EP0759026B1 (de)
JP (1) JP3419462B2 (de)
KR (1) KR100361788B1 (de)
CN (1) CN1079788C (de)
AT (1) ATE183496T1 (de)
AU (1) AU702606B2 (de)
BR (1) BR9507677A (de)
CA (1) CA2190009A1 (de)
DE (1) DE69511544T2 (de)
DK (1) DK0759026T3 (de)
ES (1) ES2134472T3 (de)
FI (1) FI964482A0 (de)
GR (1) GR3031458T3 (de)
HK (1) HK1014532A1 (de)
HU (1) HU219241B (de)
IL (3) IL113665A (de)
MX (1) MX9605458A (de)
MY (1) MY113062A (de)
NO (1) NO308654B1 (de)
NZ (1) NZ285134A (de)
RU (1) RU2145954C1 (de)
SI (1) SI0759026T1 (de)
TW (1) TW340109B (de)
WO (1) WO1995030645A1 (de)
ZA (1) ZA953753B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391282B1 (en) * 1997-11-10 2002-05-21 Flemington Pharmaceutical Corp. Antihistamine sprays and ointments for relief of delayed contact dermatitis
DE19837069C1 (de) * 1998-08-17 2000-01-05 Bayer Ag Substituierte Zimtsäuren und Zimtsäureester, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von substituierten Indanoncarbonsäureestern
EP1358150A1 (de) * 2001-02-06 2003-11-05 Glaxo Group Limited Verwendung von bicyclyschen esteren oder amiden zur behandlung von krankheiten, die auf die aktivierung des kalium kanals reagieren
US6956129B2 (en) * 2001-02-16 2005-10-18 Bayer Aktiengesellschaft Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives
EP1243262B1 (de) * 2001-03-20 2006-05-31 Schwarz Pharma Ag Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz
PT1243263E (pt) 2001-03-21 2003-03-31 Sanol Arznei Schwarz Gmbh Nova utilizacao de uma classe peptidica de composto para o tratamento de alodinia ou de outros tipos diferentes de dor cronica ou fantasma
GB0216027D0 (en) * 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
US20040048874A1 (en) * 2001-05-22 2004-03-11 Bardsley Hazel Judith New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
EP1558081A4 (de) * 2003-01-13 2006-06-14 Dynogen Pharmaceuticals Inc Verfahren zur behandlung von funktionalen darmerkrankungen
CN1950101B (zh) 2004-04-16 2011-03-30 舒沃茨药物股份公司 肽化合物用于预防和治疗慢性头痛的用途
NZ552651A (en) 2004-08-27 2010-07-30 Sanol Arznei Schwarz Gmbh Novel use of peptide compounds for treating bone cancer pain, chemotherapy-and nucleoside-induced pain
CA2623250C (en) * 2005-12-20 2014-02-18 Nps Pharmaceuticals, Inc. Fluorinated compounds
AU2007260207B2 (en) 2006-06-15 2012-11-08 Ucb Pharma Gmbh Pharmaceutical composition with synergistic anticonvulsant effect
RU2522460C1 (ru) * 2013-01-09 2014-07-10 Федеральное государственное бюджетное учреждение высшего профессионального образования "Кемеровский государственный университет" (КемГУ) Способ получения алкенилантрахинонов

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE371190B (de) * 1972-03-24 1974-11-11 Kabi Ab
US3325358A (en) * 1962-06-06 1967-06-13 Merck & Co Inc Method of treating inflammation
NO136750C (no) * 1972-06-19 1977-11-02 Takeda Chemical Industries Ltd Fremgangsm}te for fremstilling av indanderivater
JPS5623982B2 (de) * 1972-12-07 1981-06-03
US5416118A (en) * 1992-04-09 1995-05-16 Schering Corporation Bicyclic amides as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
GB9309621D0 (en) * 1993-05-11 1993-06-23 Wellcome Found Amide derivatives and their therapeutic use

Also Published As

Publication number Publication date
WO1995030645A1 (en) 1995-11-16
NZ285134A (en) 1998-03-25
MY113062A (en) 2001-11-30
GR3031458T3 (en) 2000-01-31
ES2134472T3 (es) 1999-10-01
JP3419462B2 (ja) 2003-06-23
NO964750L (no) 1996-11-08
IL124966A (en) 1999-12-22
FI964482A (fi) 1996-11-07
IL113665A0 (en) 1995-08-31
KR100361788B1 (ko) 2003-01-24
MX9605458A (es) 1998-02-28
FI964482A0 (fi) 1996-11-07
RU2145954C1 (ru) 2000-02-27
HU9603103D0 (en) 1997-01-28
NO308654B1 (no) 2000-10-09
DK0759026T3 (da) 2000-02-28
HK1014532A1 (en) 1999-09-30
EP0759026B1 (de) 1999-08-18
HU219241B (en) 2001-03-28
CA2190009A1 (en) 1995-11-16
ATE183496T1 (de) 1999-09-15
TW340109B (en) 1998-09-11
EP0759026A1 (de) 1997-02-26
DE69511544T2 (de) 1999-12-23
CN1079788C (zh) 2002-02-27
HUT76465A (en) 1997-09-29
AU702606B2 (en) 1999-02-25
IL124966A0 (en) 1999-01-26
ZA953753B (en) 1996-11-11
BR9507677A (pt) 1997-08-19
AU2413895A (en) 1995-11-29
SI0759026T1 (en) 1999-10-31
IL113665A (en) 1999-12-22
US5708033A (en) 1998-01-13
CN1153510A (zh) 1997-07-02
JPH09512814A (ja) 1997-12-22
NO964750D0 (no) 1996-11-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee