DE69510858D1 - Mukosale Verabreichung von Pneumokokken-Antigenen - Google Patents
Mukosale Verabreichung von Pneumokokken-AntigenenInfo
- Publication number
- DE69510858D1 DE69510858D1 DE69510858T DE69510858T DE69510858D1 DE 69510858 D1 DE69510858 D1 DE 69510858D1 DE 69510858 T DE69510858 T DE 69510858T DE 69510858 T DE69510858 T DE 69510858T DE 69510858 D1 DE69510858 D1 DE 69510858D1
- Authority
- DE
- Germany
- Prior art keywords
- mucosal administration
- pneumococci
- pneumococcal antigens
- against pneumococcal
- whole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 102000009016 Cholera Toxin Human genes 0.000 abstract 1
- 108010049048 Cholera Toxin Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000006166 lysate Substances 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/246,636 US5965141A (en) | 1991-02-15 | 1994-05-20 | Epitopic regions of pneumococcal surface protein a |
US08/312,949 US6027734A (en) | 1991-02-15 | 1994-09-30 | Mucosal administration of pneumococcal antigens |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69510858D1 true DE69510858D1 (de) | 1999-08-26 |
DE69510858T2 DE69510858T2 (de) | 2000-04-13 |
Family
ID=26938117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69510858T Expired - Fee Related DE69510858T2 (de) | 1994-05-20 | 1995-05-19 | Mukosale Verabreichung von Pneumokokken-Antigenen |
Country Status (13)
Country | Link |
---|---|
US (1) | US6027734A (de) |
EP (1) | EP0682950B1 (de) |
JP (1) | JP2747435B2 (de) |
AT (1) | ATE182270T1 (de) |
AU (1) | AU698724B2 (de) |
CA (1) | CA2149703A1 (de) |
DE (1) | DE69510858T2 (de) |
DK (1) | DK0682950T3 (de) |
ES (1) | ES2135663T3 (de) |
FI (1) | FI952445A (de) |
GR (1) | GR3031491T3 (de) |
IL (1) | IL113772A0 (de) |
NO (1) | NO951982L (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996039113A2 (en) * | 1995-06-02 | 1996-12-12 | Uab Research Foundation | Oral administration of pneumococcal antigens |
ZA964896B (en) * | 1995-06-07 | 1997-01-08 | Connaught Lab | Expression of lipoproteins |
US7078042B2 (en) * | 1995-09-15 | 2006-07-18 | Uab Research Foundation | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
KR20060126844A (ko) * | 1998-04-07 | 2006-12-08 | 메디뮨 인코포레이티드 | 백신용 폐렴 구균의 콜린 결합성 단백질의 유도체 |
US20010016200A1 (en) * | 1998-04-23 | 2001-08-23 | Briles David E. | Pneumococcal surface protein C (PspC), epitopic regions and strain selection thereof, and uses therefor |
WO2002029100A1 (en) * | 2000-09-29 | 2002-04-11 | Genomics Collaborative, Inc. | Methods of diagnosing community acquired pneumonia (cap) and predisposition or susceptibility for cap and associated septic shock through detection of gene polymorphisms |
US6929798B2 (en) * | 2002-02-13 | 2005-08-16 | Immunology Laboratories, Inc. | Compositions and methods for treatment of microbial infections |
EP1668112A4 (de) | 2003-06-20 | 2009-04-29 | Protein Sciences Corp | Sars-immunogene exprimierende vektoren, solche vektoren oder expressionsprodukte davon enthaltende zusammensetzungen, verfahren und tests zur herstellung und verwendung |
CN102861325A (zh) * | 2003-11-10 | 2013-01-09 | Uab研究基金会 | 减少细菌携带和中枢神经系统侵害的组合物及其使用方法 |
CA2661210A1 (en) * | 2006-08-17 | 2008-02-21 | The Uab Research Foundation | Diagnosing pneumococcal pneumonia |
WO2008143676A1 (en) | 2007-05-23 | 2008-11-27 | The Uab Research Foundation | Detoxified pneumococcal neuraminidase and uses thereof |
CN109289045A (zh) | 2012-09-19 | 2019-02-01 | 国立大学法人大阪大学 | 含有肺炎球菌表面蛋白a的肺炎球菌疫苗 |
US11053532B2 (en) | 2017-04-19 | 2021-07-06 | CAP Diagnostics, LLC | Methods for treating polymicrobial infections |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6444889U (de) * | 1987-09-14 | 1989-03-17 | ||
JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
EP0786521A1 (de) * | 1991-02-15 | 1997-07-30 | Uab Research Foundation | Für PspA kodierende Nukleinsäure |
WO1994014318A1 (en) * | 1992-12-24 | 1994-07-07 | Medimmune, Inc. | Method of protection against streptococcus pneumoniae with transformed mycobacteria |
CA2116261A1 (en) * | 1993-04-20 | 1994-10-21 | David E. Briles | Epitopic regions of pneumococcal surface protein a |
-
1994
- 1994-09-30 US US08/312,949 patent/US6027734A/en not_active Expired - Lifetime
-
1995
- 1995-05-18 CA CA002149703A patent/CA2149703A1/en not_active Abandoned
- 1995-05-18 IL IL11377295A patent/IL113772A0/xx unknown
- 1995-05-19 NO NO951982A patent/NO951982L/no not_active Application Discontinuation
- 1995-05-19 FI FI952445A patent/FI952445A/fi unknown
- 1995-05-19 DK DK95303365T patent/DK0682950T3/da active
- 1995-05-19 AU AU20150/95A patent/AU698724B2/en not_active Ceased
- 1995-05-19 EP EP95303365A patent/EP0682950B1/de not_active Expired - Lifetime
- 1995-05-19 ES ES95303365T patent/ES2135663T3/es not_active Expired - Lifetime
- 1995-05-19 DE DE69510858T patent/DE69510858T2/de not_active Expired - Fee Related
- 1995-05-19 AT AT95303365T patent/ATE182270T1/de not_active IP Right Cessation
- 1995-05-22 JP JP7122859A patent/JP2747435B2/ja not_active Expired - Fee Related
-
1999
- 1999-10-08 GR GR990402584T patent/GR3031491T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL113772A0 (en) | 1995-08-31 |
DE69510858T2 (de) | 2000-04-13 |
ATE182270T1 (de) | 1999-08-15 |
FI952445A0 (fi) | 1995-05-19 |
EP0682950A1 (de) | 1995-11-22 |
GR3031491T3 (en) | 2000-01-31 |
JPH0840927A (ja) | 1996-02-13 |
AU698724B2 (en) | 1998-11-05 |
JP2747435B2 (ja) | 1998-05-06 |
ES2135663T3 (es) | 1999-11-01 |
NO951982L (no) | 1995-11-21 |
US6027734A (en) | 2000-02-22 |
EP0682950B1 (de) | 1999-07-21 |
CA2149703A1 (en) | 1995-11-21 |
NO951982D0 (no) | 1995-05-19 |
AU2015095A (en) | 1995-11-30 |
DK0682950T3 (da) | 1999-11-29 |
FI952445A (fi) | 1995-11-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |