WO1996039113A3 - Oral administration of pneumococcal antigens - Google Patents

Oral administration of pneumococcal antigens Download PDF

Info

Publication number
WO1996039113A3
WO1996039113A3 PCT/IB1996/001051 IB9601051W WO9639113A3 WO 1996039113 A3 WO1996039113 A3 WO 1996039113A3 IB 9601051 W IB9601051 W IB 9601051W WO 9639113 A3 WO9639113 A3 WO 9639113A3
Authority
WO
WIPO (PCT)
Prior art keywords
pneumococci
oral administration
colonization
host
against pneumococcal
Prior art date
Application number
PCT/IB1996/001051
Other languages
French (fr)
Other versions
WO1996039113A2 (en
Inventor
David E Briles
Larry S Mcdaniel
Masafumi Yamamoto
Hiroshi Kiyono
Original Assignee
Uab Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/458,399 external-priority patent/US6231870B1/en
Priority claimed from US08/482,981 external-priority patent/US6232116B1/en
Priority claimed from US08/657,751 external-priority patent/US6004802A/en
Application filed by Uab Research Foundation filed Critical Uab Research Foundation
Priority to EP96931208A priority Critical patent/EP0871479A2/en
Priority to AU69985/96A priority patent/AU709368B2/en
Priority to JP9500289A priority patent/JP2000502987A/en
Publication of WO1996039113A2 publication Critical patent/WO1996039113A2/en
Publication of WO1996039113A3 publication Critical patent/WO1996039113A3/en
Priority to FI974376A priority patent/FI974376A/en
Priority to NO975522A priority patent/NO975522L/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Oral or peroral administration, including intragastrically, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with an adjuvant such as cholera toxin provides protection in a host, animal or human, against pneumococcal infection, including colonization, and systemic infection, such as sepsis. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, wich can lead to elimination of disease from the population as a whole.
PCT/IB1996/001051 1995-06-02 1996-05-31 Oral administration of pneumococcal antigens WO1996039113A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP96931208A EP0871479A2 (en) 1995-06-02 1996-05-31 Oral administration of pneumococcal antigens
AU69985/96A AU709368B2 (en) 1995-06-02 1996-05-31 Oral administration of pneumococcal antigens
JP9500289A JP2000502987A (en) 1995-06-02 1996-05-31 Oral administration of pneumococcal antigen
FI974376A FI974376A (en) 1995-06-02 1997-12-01 Oral administration of pneumococcal antigens
NO975522A NO975522L (en) 1995-06-02 1997-12-01 Oral administration of pneumococcal antigen

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/458,399 US6231870B1 (en) 1995-06-02 1995-06-02 Oral administration of pneumoccal antigens
US08/458,399 1995-06-02
US08/482,981 1995-06-07
US08/482,981 US6232116B1 (en) 1991-02-15 1995-06-07 Oral administration of pneumococcal antigens
US08/657,751 US6004802A (en) 1995-06-02 1996-05-30 Oral administration of pneumococcal antigens
US08/657,751 1996-05-30

Publications (2)

Publication Number Publication Date
WO1996039113A2 WO1996039113A2 (en) 1996-12-12
WO1996039113A3 true WO1996039113A3 (en) 1997-06-05

Family

ID=27412732

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1996/001051 WO1996039113A2 (en) 1995-06-02 1996-05-31 Oral administration of pneumococcal antigens

Country Status (6)

Country Link
EP (1) EP0871479A2 (en)
AU (1) AU709368B2 (en)
CA (1) CA2222965A1 (en)
FI (1) FI974376A (en)
NO (1) NO975522L (en)
WO (1) WO1996039113A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19703437A1 (en) * 1997-01-30 1998-08-06 Luitpold Pharma Gmbh Mixtures of outer membranes and / or cell walls of bacteria for oral immunization against mucosal infections
KR19980067137A (en) * 1997-01-31 1998-10-15 박원훈 Vaccine against pneumococcal pneumoniae using alginate ultrafine granulocytes
DE19708537A1 (en) * 1997-03-03 1998-09-10 Biotechnolog Forschung Gmbh New surface protein (SpsA protein) from Streptococcus pneumoniae etc.
WO2008109958A1 (en) * 2007-03-15 2008-09-18 Hunter Immunology Limited Methods for evaluation of oral vaccines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014488A1 (en) * 1991-02-15 1992-09-03 Uab Research Foundation Structural gene of pneumococcal protein

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6027734A (en) * 1991-02-15 2000-02-22 Uab Research Foundation Mucosal administration of pneumococcal antigens
US5980909A (en) * 1991-02-15 1999-11-09 Uab Research Foundation Epitopic regions of pneumococcal surface protein A

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014488A1 (en) * 1991-02-15 1992-09-03 Uab Research Foundation Structural gene of pneumococcal protein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ABSTRACTS OF THE 92ND GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, May 1992, page 127, Abstract D-189, YOTHER et al., "Secretion of PspA-CTB Fusion Products from Streptococcus Pneumoniae and Escherichia Coli". *

Also Published As

Publication number Publication date
WO1996039113A2 (en) 1996-12-12
EP0871479A4 (en) 1998-11-11
FI974376A (en) 1998-01-26
CA2222965A1 (en) 1996-12-12
NO975522D0 (en) 1997-12-01
AU709368B2 (en) 1999-08-26
EP0871479A2 (en) 1998-10-21
AU6998596A (en) 1996-12-24
NO975522L (en) 1998-02-02
FI974376A0 (en) 1997-12-01

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