DE69507614D1 - 3-amino-2-oxo-piperidinessigsäurederivate, die eine argininnachahmende verbindung, mit enzyminhibitorischen wirkung enthalten - Google Patents
3-amino-2-oxo-piperidinessigsäurederivate, die eine argininnachahmende verbindung, mit enzyminhibitorischen wirkung enthaltenInfo
- Publication number
- DE69507614D1 DE69507614D1 DE69507614T DE69507614T DE69507614D1 DE 69507614 D1 DE69507614 D1 DE 69507614D1 DE 69507614 T DE69507614 T DE 69507614T DE 69507614 T DE69507614 T DE 69507614T DE 69507614 D1 DE69507614 D1 DE 69507614D1
- Authority
- DE
- Germany
- Prior art keywords
- piperidinessigic
- enzyminhibitoric
- arginine
- oxo
- compatible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/261,498 US5714499A (en) | 1994-06-17 | 1994-06-17 | 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors |
US35683194A | 1994-12-13 | 1994-12-13 | |
US08/482,117 US5932733A (en) | 1994-06-17 | 1995-06-07 | 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors |
PCT/US1995/007832 WO1995035313A1 (en) | 1994-06-17 | 1995-06-19 | 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69507614D1 true DE69507614D1 (de) | 1999-03-11 |
Family
ID=27401415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69507614T Expired - Lifetime DE69507614D1 (de) | 1994-06-17 | 1995-06-19 | 3-amino-2-oxo-piperidinessigsäurederivate, die eine argininnachahmende verbindung, mit enzyminhibitorischen wirkung enthalten |
Country Status (8)
Country | Link |
---|---|
US (1) | US5932733A (de) |
EP (1) | EP0765339B1 (de) |
JP (1) | JPH10503177A (de) |
AT (1) | ATE176241T1 (de) |
AU (1) | AU2905495A (de) |
CA (1) | CA2192211A1 (de) |
DE (1) | DE69507614D1 (de) |
WO (1) | WO1995035313A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6011158A (en) * | 1994-12-13 | 2000-01-04 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US6342504B1 (en) | 1994-12-13 | 2002-01-29 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
CA2176414A1 (en) * | 1995-05-18 | 1996-11-19 | S. David Kimball | Acyl guanidine and amidine prodrugs |
WO1998009987A1 (en) * | 1996-09-06 | 1998-03-12 | Biochem Pharma, Inc. | Lactam inhibitors of thrombin |
US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
CA2268264A1 (en) * | 1996-10-11 | 1998-04-23 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
CA2285659A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
NZ500353A (en) | 1997-04-14 | 2002-02-01 | Cor Therapeutics Inc | Cyclic diaza compounds that are selective inhibitors of factor Xa |
WO1998046628A1 (en) * | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
US7109326B2 (en) | 1997-04-15 | 2006-09-19 | Genentech, Inc. | Halo-alkoxycarbonyl prodrugs |
US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
US6204384B1 (en) | 1997-11-26 | 2001-03-20 | Corvas International, Inc. | Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II) |
US6011047A (en) * | 1997-11-26 | 2000-01-04 | Corvas International Inc. | Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors |
AU1605699A (en) * | 1997-11-26 | 1999-06-15 | Corvas International, Inc. | Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (ii) |
US6344450B1 (en) | 1999-02-09 | 2002-02-05 | Bristol-Myers Squibb Company | Lactam compounds and their use as inhibitors of serine proteases and method |
EP1156803A4 (de) | 1999-02-09 | 2004-03-17 | Bristol Myers Squibb Co | LACTAM INHIBITOREN DES FXa UND METHODE |
WO2001036351A2 (en) | 1999-11-19 | 2001-05-25 | Corvas International, Inc. | Plasminogen activator inhibitor antagonists related applications |
US6541467B1 (en) * | 2000-04-14 | 2003-04-01 | Corvas International, Inc. | Thrombin inhibitors having a lactam at P3 |
US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
ES2284817T3 (es) | 2001-01-26 | 2007-11-16 | Chugai Seiyaku Kabushiki Kaisha | Procedimientos para el tratamiento de enfermedades con inhibidores de la malonil coa descarboxilasa. |
JP4267920B2 (ja) | 2001-01-26 | 2009-05-27 | 中外製薬株式会社 | 代謝調節剤として有用なマロニル−CoA脱炭酸酵素阻害剤 |
CA2735478C (en) | 2001-01-26 | 2014-07-08 | Chugai Seiyaku Kabushiki Kaisha | Malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
CA2436774A1 (en) | 2001-01-30 | 2002-08-08 | R. Michael Lawrence | Sulfonamide lactam inhibitors of factor xa |
WO2002066035A2 (en) | 2001-02-20 | 2002-08-29 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
US6777431B2 (en) | 2001-07-13 | 2004-08-17 | Corvas International, Inc. | Non-convalent thrombin inhibitors |
GB0127568D0 (en) * | 2001-11-16 | 2002-01-09 | Glaxo Group Ltd | Chemical compounds |
WO2005011670A1 (en) | 2003-08-01 | 2005-02-10 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic compounds useful as malonyl-coa decarboxylase inhibitors |
ATE400272T1 (de) | 2003-08-01 | 2008-07-15 | Chugai Pharmaceutical Co Ltd | Piperidin-verbindungen als malonyl-coa decarboxylase-hemmer |
EP2208495B1 (de) | 2003-08-01 | 2011-12-14 | Chugai Seiyaku Kabushiki Kaisha | Azol-Verbindungen auf Cyanoguanidin-Basis als Malonyl-Coa Decarboxylase-Hemmer |
CA2533763C (en) | 2003-08-01 | 2012-11-20 | Chugai Seiyaku Kabushiki Kaisha | Cyanoamide compounds useful as malonyl-coa decarboxylase inhibitors |
JP2007514742A (ja) * | 2003-12-18 | 2007-06-07 | アストラゼネカ アクチボラグ | トロンビンの阻害薬として有用な新規5,6−ジヒドロピリジン−2−オン化合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5754157A (en) * | 1980-09-19 | 1982-03-31 | Nippon Kayaku Co Ltd | L-argininal derivative and its preparation |
HU184368B (en) * | 1981-01-13 | 1984-08-28 | Gyogyszerkutato Intezet | Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate |
US4433152A (en) * | 1981-05-25 | 1984-02-21 | Nippon Chemiphar Co., Ltd. | Amidinopiperidine derivatives |
CA2075154A1 (en) * | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5371072A (en) * | 1992-10-16 | 1994-12-06 | Corvas International, Inc. | Asp-Pro-Arg α-keto-amide enzyme inhibitors |
JP3466614B2 (ja) * | 1993-02-12 | 2003-11-17 | コルバス・インターナショナル、インコーポレイテッド | 血栓症のインヒビター |
-
1995
- 1995-06-07 US US08/482,117 patent/US5932733A/en not_active Expired - Lifetime
- 1995-06-19 AT AT95924623T patent/ATE176241T1/de not_active IP Right Cessation
- 1995-06-19 EP EP95924623A patent/EP0765339B1/de not_active Expired - Lifetime
- 1995-06-19 JP JP8502570A patent/JPH10503177A/ja active Pending
- 1995-06-19 AU AU29054/95A patent/AU2905495A/en not_active Abandoned
- 1995-06-19 DE DE69507614T patent/DE69507614D1/de not_active Expired - Lifetime
- 1995-06-19 CA CA002192211A patent/CA2192211A1/en not_active Abandoned
- 1995-06-19 WO PCT/US1995/007832 patent/WO1995035313A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0765339A1 (de) | 1997-04-02 |
JPH10503177A (ja) | 1998-03-24 |
ATE176241T1 (de) | 1999-02-15 |
CA2192211A1 (en) | 1995-12-28 |
US5932733A (en) | 1999-08-03 |
EP0765339B1 (de) | 1999-01-27 |
WO1995035313A1 (en) | 1995-12-28 |
AU2905495A (en) | 1996-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |