DE69431049T2 - Stickstoff-schwefel-liganden auf imidazolbasis verwendbar in radiographischen abbildungsmitteln - Google Patents

Stickstoff-schwefel-liganden auf imidazolbasis verwendbar in radiographischen abbildungsmitteln

Info

Publication number
DE69431049T2
DE69431049T2 DE69431049T DE69431049T DE69431049T2 DE 69431049 T2 DE69431049 T2 DE 69431049T2 DE 69431049 T DE69431049 T DE 69431049T DE 69431049 T DE69431049 T DE 69431049T DE 69431049 T2 DE69431049 T2 DE 69431049T2
Authority
DE
Germany
Prior art keywords
imidazole
radiographic imaging
imaging agents
ligands used
based nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431049T
Other languages
English (en)
Other versions
DE69431049D1 (de
Inventor
Raghavan Rajagopalan
Ananthachari Srinivasan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DE69431049D1 publication Critical patent/DE69431049D1/de
Publication of DE69431049T2 publication Critical patent/DE69431049T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69431049T 1993-03-12 1994-03-09 Stickstoff-schwefel-liganden auf imidazolbasis verwendbar in radiographischen abbildungsmitteln Expired - Fee Related DE69431049T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3094093A 1993-03-12 1993-03-12
PCT/US1994/002483 WO1994020148A1 (en) 1993-03-12 1994-03-09 Imidazole based nitrogen-sulfur ligands useful in radiographic imaging agents

Publications (2)

Publication Number Publication Date
DE69431049D1 DE69431049D1 (de) 2002-08-29
DE69431049T2 true DE69431049T2 (de) 2003-03-13

Family

ID=21856803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431049T Expired - Fee Related DE69431049T2 (de) 1993-03-12 1994-03-09 Stickstoff-schwefel-liganden auf imidazolbasis verwendbar in radiographischen abbildungsmitteln

Country Status (6)

Country Link
US (2) US5623077A (de)
EP (1) EP0689463B1 (de)
JP (1) JPH08507528A (de)
AU (1) AU6362294A (de)
DE (1) DE69431049T2 (de)
WO (1) WO1994020148A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0518952A2 (pt) * 2004-12-17 2008-12-16 Koninkl Philips Electronics Nv mÉtodo para a produÇço de um agente de contraste marcador ou um agente terapÊutico, agentes de contraste marcadores, e, uso dos agentes de contraste marcadores ou dos agentes terapÊuticos de marcaÇço

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52111572A (en) * 1976-03-16 1977-09-19 Santen Pharmaceutical Co Ltd Nn*mercapto substituted acyl**hystidine
US4193979A (en) * 1978-05-22 1980-03-18 G. D. Searle & Co. Sodium 3-[[[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-amino]carbonyl]-2-pyridinecarboxylic acid and related compounds labeled with technetium-99m
JPS5692276A (en) * 1979-12-26 1981-07-25 Nippon Chemiphar Co Ltd Dialuminum salt of n-(beta-(n'-acylamino)propionyl) histidine and its preparation
EP0322876A3 (de) * 1987-12-29 1990-09-05 Nihon Medi-Physics Co., Ltd. Chelierende Verbindungen und deren Verwendung
ES2009921A6 (es) * 1988-05-26 1989-10-16 Vinas Lab Procedimiento para la obtencion de derivados imidazolicos.
US5011925A (en) * 1989-03-09 1991-04-30 Mallinckrodt, Inc. Morpholinoamido EDTA derivatives
US5376356A (en) * 1989-03-14 1994-12-27 Neorx Corporation Imaging tissue sites of inflammation
FR2655339B2 (fr) * 1989-04-19 1992-04-10 Medgenix Group Sa Composes et complexes utiles notamment en imagerie medicale.
DE3930674A1 (de) * 1989-09-11 1991-03-21 Diagnostikforschung Inst Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5217706A (en) * 1990-11-21 1993-06-08 Mallinckrodt Medical, Inc. Complexes and compositions for magnetic resonance imaging
US5330737A (en) * 1991-12-06 1994-07-19 Mallinckrodt Medical, Inc. Nitrogen-sulfur ligands as opiate receptor drug mimics
US5371184A (en) * 1992-02-05 1994-12-06 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds

Also Published As

Publication number Publication date
US5623077A (en) 1997-04-22
AU6362294A (en) 1994-09-26
EP0689463A1 (de) 1996-01-03
EP0689463B1 (de) 2002-07-24
WO1994020148A1 (en) 1994-09-15
US5653958A (en) 1997-08-05
JPH08507528A (ja) 1996-08-13
EP0689463A4 (de) 1996-08-21
DE69431049D1 (de) 2002-08-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee