DE69429821D1 - Farnesyl-derivate und diese enthaltende arzneimittel - Google Patents
Farnesyl-derivate und diese enthaltende arzneimittelInfo
- Publication number
- DE69429821D1 DE69429821D1 DE69429821T DE69429821T DE69429821D1 DE 69429821 D1 DE69429821 D1 DE 69429821D1 DE 69429821 T DE69429821 T DE 69429821T DE 69429821 T DE69429821 T DE 69429821T DE 69429821 D1 DE69429821 D1 DE 69429821D1
- Authority
- DE
- Germany
- Prior art keywords
- products containing
- medicinal products
- farnesyl derivatives
- farnesyl
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL10758793A IL107587A (en) | 1993-11-12 | 1993-11-12 | Farnesyl geranyl or geranyl-geranyl derivatives pharmaceutical compositions containing them and methods for their preparation |
PCT/US1994/013345 WO1995013059A1 (en) | 1993-11-12 | 1994-11-10 | Farnesyl derivatives and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69429821D1 true DE69429821D1 (de) | 2002-03-21 |
DE69429821T2 DE69429821T2 (de) | 2002-11-28 |
Family
ID=11065450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69429821T Expired - Lifetime DE69429821T2 (de) | 1993-11-12 | 1994-11-10 | Farnesyl-derivate und diese enthaltende arzneimittel |
Country Status (7)
Country | Link |
---|---|
US (2) | US5705528A (de) |
EP (1) | EP0729354B1 (de) |
AU (1) | AU1396395A (de) |
CA (1) | CA2176373C (de) |
DE (1) | DE69429821T2 (de) |
IL (1) | IL107587A (de) |
WO (1) | WO1995013059A1 (de) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6117641A (en) | 1996-04-11 | 2000-09-12 | Mitotix, Inc. | Assays and reagents for identifying anti-fungal agents and uses related thereto |
US6727082B1 (en) | 1996-04-11 | 2004-04-27 | Gpc Biotech Inc. | Assays and reagents for identifying anti-fungal agents, and uses related thereto |
DE69713759T2 (de) | 1996-04-11 | 2003-03-13 | Mitotix Inc | Assays und reaganzien zur identifizierung von fungiziden wirkstoffen und ihre verwendungen |
WO1998038509A1 (en) * | 1997-02-26 | 1998-09-03 | Thyreos Corporation | Drug screen targeting lipoprotein-membrane anchorage |
US6303654B1 (en) * | 1998-03-12 | 2001-10-16 | Wisconsin Alumni Research Foundation | Acyclic monoterpenoid derivatives |
WO1999055878A1 (en) * | 1998-04-24 | 1999-11-04 | Onyx Pharmaceuticals, Inc. | Novel nucleic acids and polypeptides related to a farnesyl-directed cysteine carboxymethyltransferase |
US20020115696A1 (en) * | 1999-06-18 | 2002-08-22 | Yoel Kloog | Treatment of post-angioplasty restenosis and atherosclerosis with ras antagonists |
US20050119237A1 (en) * | 1999-06-18 | 2005-06-02 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Non-malignant disease treatment with Ras antagonists |
EP1187605A4 (de) * | 1999-06-18 | 2004-05-26 | Thyreos Corp | BEHANDLUNG DER NICHT BöSARTIGEN KRANKHEITEN MIT RAS-ANTAGONISTEN |
US6576261B1 (en) * | 1999-08-11 | 2003-06-10 | Josef Pitha | Potentiation of inclusion complex formation of cyclodextrin derivatives |
US6372793B1 (en) | 1999-08-20 | 2002-04-16 | Florida Agricultural & Mechanical University | Method for treatment of a neurological disease characterized by impaired neuromodulator function |
WO2004103352A1 (en) * | 2003-05-23 | 2004-12-02 | Ramot At Tel Aviv University, Ltd. | Ras antagonists for treating neurodegenerative disorders |
JP2007503442A (ja) * | 2003-08-22 | 2007-02-22 | ユニバーシティ オブ ヴァージニア パテント ファウンデーション | ホルモン適応反応を阻止するためのmTOR遮断 |
US8338648B2 (en) * | 2004-06-12 | 2012-12-25 | Signum Biosciences, Inc. | Topical compositions and methods for epithelial-related conditions |
AU2005254035B2 (en) * | 2004-06-12 | 2011-03-24 | Elizabeth Arden, Inc. | Topical compositions and methods for epithelial-related conditions |
ES2414861T3 (es) | 2004-08-18 | 2013-07-23 | Kadmon Corporation, Llc | Uso del FTS para el tratamiento de trastornos malignos |
US8278349B2 (en) * | 2005-11-28 | 2012-10-02 | Ramot At Tel-Aviv University Ltd. | Cancer treatment using FTS and 2-deoxyglucose |
EP1986625B1 (de) * | 2006-02-10 | 2012-08-01 | Ramot at Tel-Aviv University Ltd. | Behandlung von ovarialkrebs |
WO2007116396A1 (en) * | 2006-04-11 | 2007-10-18 | Ramot At Tel Aviv University Ltd. | Treatment of hematological malignancies with fts and a bcr-abl tyrosine kinase inhibitor |
US20110046223A1 (en) * | 2006-06-14 | 2011-02-24 | Ramot At Tel-Aviv University Ltd. | Treatment of neurofibromatosis |
ATE543492T1 (de) | 2006-12-19 | 2012-02-15 | Univ Ramot | Behandlung von lungenkrebs |
WO2008126094A1 (en) * | 2007-04-17 | 2008-10-23 | Ramot At Tel Aviv University Ltd. | Treatment of myocarditis using fts |
US7897604B2 (en) * | 2008-04-07 | 2011-03-01 | Florida Agricultural And Mechanical University | Inhibitors of polyisoprenylated methylated protein methyl esterase |
US9051548B2 (en) | 2009-02-03 | 2015-06-09 | Children's Medical Center Corporation | Methods for enhancing hematopoietic stem/progenitor cell engraftment |
WO2010096264A2 (en) | 2009-02-03 | 2010-08-26 | Children's Medical Center Corporation | Methods for enhancing hematopoietic stem/progenitor cell engraftment |
WO2011051938A1 (en) * | 2009-10-26 | 2011-05-05 | Ramot At Tel-Aviv University Ltd. | Composition for treatment of thyroid cancer with fts and analogs thereof |
CN102655745B (zh) | 2009-11-12 | 2016-01-06 | 西格纳姆生物科学公司 | 抗细菌剂用于治疗上皮相关病况的用途 |
US8592173B2 (en) | 2011-01-25 | 2013-11-26 | Florida Agricultural And Mechanical University | Cancer diagnosis by measuring polyisoprenylated methylated protein methyl esterase activity |
US8053207B1 (en) | 2011-01-25 | 2011-11-08 | Florida Agrlcultural and Mechanical University | Cancer diagnosis by measuring polyisoprenylated methylated protein methyl esterase activity |
US9738614B2 (en) | 2011-10-07 | 2017-08-22 | Pisces Therapeutics, Llc | Malignant and non-malignant disease treatment with Ras antagonists |
RU2632097C2 (ru) | 2011-10-07 | 2017-10-02 | ПАЙСИЗ ТЕРАПЬЮТИКЗ ЭлЭлСи | Лечение злокачественных и незлокачественных заболеваний с помощью антагонистов ras |
KR20150085509A (ko) * | 2012-09-21 | 2015-07-23 | 바질 리가스 | 염증-관련 장애, 통증 및 열, 피부 장애, 암 및 이의 전암성 질환의 치료용 조성물 |
US9855341B2 (en) | 2014-02-19 | 2018-01-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Formulations and carrier systems including farnesylthiosalycylic moities |
EP3269365A1 (de) | 2016-07-14 | 2018-01-17 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Kras-hemmer zur behandlung von krebs |
WO2019204799A1 (en) | 2018-04-20 | 2019-10-24 | University Of Pittsburgh -Of The Commonwealth System Of Higher Education | Cationic amphiphilic polymers for codelivery of hydrophobic agents and nucleic acids |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3879429A (en) | 1969-04-30 | 1975-04-22 | Hoffmann La Roche | Phenyl derivatives |
CH568708A5 (de) | 1969-04-30 | 1975-11-14 | Hoffmann La Roche | |
US3910894A (en) * | 1970-05-14 | 1975-10-07 | Du Pont | Insect hormone mimics |
AU2843371A (en) * | 1970-05-22 | 1972-11-09 | Ceskoslovenska Akademie Ved | Novel compounds |
JPS4924215A (de) | 1972-07-03 | 1974-03-04 | ||
NL191744C (nl) * | 1980-04-07 | 1996-06-04 | Eisai Co Ltd | Farmaceutisch preparaat met werking tegen epitheelletsels. |
DE3862411D1 (de) * | 1987-03-17 | 1991-05-23 | Kuraray Co | Verfahren zur herstellung von sulfonen. |
DE3738406A1 (de) * | 1987-11-12 | 1989-05-24 | Henkel Kgaa | Sebosuppressive topische zubereitungen |
CA2076012A1 (en) * | 1990-02-14 | 1991-08-15 | Yasuyuki Kato | Agent for inhibiting the formation of denatured ldl |
US5043268A (en) * | 1990-05-04 | 1991-08-27 | The Trustees Of Princeton University | Substrates and inhibitors for prenyl cysteine methyltransferase enzymes |
CA2050514A1 (en) * | 1990-09-14 | 1992-03-15 | Bradley C. Pearce | Acyclic tocotrienol analogs in the treatment of hypercholesterolemia and hyperlipidemia |
US5202456A (en) * | 1991-04-15 | 1993-04-13 | The President And Fellows Of Harvard College | Compounds for inhibition of protein methylation |
-
1993
- 1993-11-12 IL IL10758793A patent/IL107587A/en not_active IP Right Cessation
-
1994
- 1994-11-10 US US08/338,764 patent/US5705528A/en not_active Ceased
- 1994-11-10 DE DE69429821T patent/DE69429821T2/de not_active Expired - Lifetime
- 1994-11-10 EP EP95905295A patent/EP0729354B1/de not_active Expired - Lifetime
- 1994-11-10 WO PCT/US1994/013345 patent/WO1995013059A1/en active IP Right Grant
- 1994-11-10 CA CA002176373A patent/CA2176373C/en not_active Expired - Lifetime
- 1994-11-10 AU AU13963/95A patent/AU1396395A/en not_active Abandoned
-
2005
- 2005-03-30 US US11/093,255 patent/USRE39682E1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0729354A1 (de) | 1996-09-04 |
WO1995013059A1 (en) | 1995-05-18 |
DE69429821T2 (de) | 2002-11-28 |
AU1396395A (en) | 1995-05-29 |
JPH09508618A (ja) | 1997-09-02 |
CA2176373C (en) | 2009-03-24 |
IL107587A (en) | 1998-08-16 |
JP3757236B2 (ja) | 2006-03-22 |
EP0729354B1 (de) | 2002-02-06 |
USRE39682E1 (en) | 2007-06-05 |
CA2176373A1 (en) | 1995-05-18 |
US5705528A (en) | 1998-01-06 |
EP0729354A4 (de) | 1996-07-15 |
IL107587A0 (en) | 1994-02-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8328 | Change in the person/name/address of the agent |
Representative=s name: KRAMER - BARSKE - SCHMIDTCHEN, 81245 MUENCHEN |