DE69429345T2 - Überzug für hydrophobe oberflächen um diese proteinresistent zu machen unter ermöglichung der kovalenten bindung spezifischer liganden - Google Patents
Überzug für hydrophobe oberflächen um diese proteinresistent zu machen unter ermöglichung der kovalenten bindung spezifischer ligandenInfo
- Publication number
- DE69429345T2 DE69429345T2 DE69429345T DE69429345T DE69429345T2 DE 69429345 T2 DE69429345 T2 DE 69429345T2 DE 69429345 T DE69429345 T DE 69429345T DE 69429345 T DE69429345 T DE 69429345T DE 69429345 T2 DE69429345 T2 DE 69429345T2
- Authority
- DE
- Germany
- Prior art keywords
- protein
- resistant
- allowing
- coating
- make
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/02—Compounds containing any of the groups, e.g. carbazates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/823—Immunogenic carrier or carrier per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/110,169 US5516703A (en) | 1993-08-20 | 1993-08-20 | Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands |
PCT/US1994/009480 WO1995006251A1 (en) | 1993-08-20 | 1994-08-22 | Coating of hydrophobic surfaces to render them protein resistant while permitting covalent attachment of specific ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69429345D1 DE69429345D1 (de) | 2002-01-17 |
DE69429345T2 true DE69429345T2 (de) | 2002-08-14 |
Family
ID=22331580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69429345T Expired - Lifetime DE69429345T2 (de) | 1993-08-20 | 1994-08-22 | Überzug für hydrophobe oberflächen um diese proteinresistent zu machen unter ermöglichung der kovalenten bindung spezifischer liganden |
Country Status (5)
Country | Link |
---|---|
US (2) | US5516703A (de) |
EP (1) | EP0701697B1 (de) |
CA (1) | CA2163519C (de) |
DE (1) | DE69429345T2 (de) |
WO (1) | WO1995006251A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6284503B1 (en) * | 1993-08-20 | 2001-09-04 | University Of Utah Research Foundation | Composition and method for regulating the adhesion of cells and biomolecules to hydrophobic surfaces |
ATE243230T1 (de) * | 1995-11-01 | 2003-07-15 | Bracco Research Sa | Gelierte magnetisch markierte molekularsysteme als nmr-bilderzeugungsmittel |
US5874165A (en) * | 1996-06-03 | 1999-02-23 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto polymeric subtrates |
US5681754A (en) * | 1996-06-07 | 1997-10-28 | Abbott Laboratories | Method for improving the performance of an immunoreagent in an immunoassay |
US6093559A (en) | 1996-10-24 | 2000-07-25 | Corning Incorporated | Producing low binding hydrophobic surfaces by treating with a low HLB number non-ionic surfactant |
US5858801A (en) * | 1997-03-13 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Patterning antibodies on a surface |
US6235541B1 (en) | 1997-03-13 | 2001-05-22 | The United States Of America As Represented By The Secretary Of The Navy | Patterning antibodies on a surface |
DE19748489A1 (de) * | 1997-11-03 | 1999-05-06 | Roche Diagnostics Gmbh | Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren |
US6897297B1 (en) * | 1997-12-03 | 2005-05-24 | Curis, Inc. | Hydrophobically-modified protein compositions and methods |
US6087452A (en) * | 1998-06-02 | 2000-07-11 | University Of Utah | Metal-chelating surfacant |
DE69933376T2 (de) * | 1998-06-05 | 2007-08-02 | Arkray, Inc. | Vorrichtung zur messung der ionenaktivität |
US6706161B1 (en) * | 1998-06-10 | 2004-03-16 | Agilent Technologies, Inc. | Methods and compositions for modifying the surface of a polymeric substrate |
US7138254B2 (en) | 1999-08-02 | 2006-11-21 | Ge Healthcare (Sv) Corp. | Methods and apparatus for performing submicroliter reactions with nucleic acids or proteins |
US6319674B1 (en) | 1999-09-16 | 2001-11-20 | Agilent Technologies, Inc. | Methods for attaching substances to surfaces |
WO2002030571A2 (en) * | 2000-10-10 | 2002-04-18 | Genset S.A. | Surface adsorbing polymers and the uses thereof to treat hydrophobic or hydrophilic surfaces |
SE0004532D0 (sv) * | 2000-12-07 | 2000-12-07 | Caldwell Karin Dahlgren | Use of mucin |
DE10064827A1 (de) | 2000-12-22 | 2002-06-27 | Dade Behring Marburg Gmbh | Nachweisverfahren |
JP4328533B2 (ja) * | 2001-02-02 | 2009-09-09 | オールヴィヴォ インコーポレイテッド | 複数の生体分子を規定の比率にて表面に共に固定化する方法及び同方法により形成された表面 |
US6844028B2 (en) * | 2001-06-26 | 2005-01-18 | Accelr8 Technology Corporation | Functional surface coating |
US7501157B2 (en) * | 2001-06-26 | 2009-03-10 | Accelr8 Technology Corporation | Hydroxyl functional surface coating |
US20030148017A1 (en) * | 2001-12-07 | 2003-08-07 | Olli Tuominen | Copolymer coating for a hydrophobic membrane |
DE10162435A1 (de) * | 2001-12-19 | 2003-07-17 | Joerg Lahann | Verfahren zur Erzeugung von Oberflächenbeschichtungen, die die Adsorption von Proteinen bzw. die Adhäsion von Bakterien und/oder Zellen vermindern |
US7217512B2 (en) * | 2002-05-09 | 2007-05-15 | Corning Incorporated | Reagent and method for attaching target molecules to a surface |
DE10233303A1 (de) * | 2002-07-22 | 2004-02-12 | Micronas Holding Gmbh | Sensoroberfläche mit verbessertem Signal/Rausch-Verhältnis |
EP1387169B1 (de) * | 2002-08-02 | 2006-05-24 | Sony Deutschland GmbH | Verfahren zur Bindung hydophiler Substanzen an hydrophile Makromoleküle und Immobilisierung derselben auf hydrophoben Oberflächen |
US20050233473A1 (en) * | 2002-08-16 | 2005-10-20 | Zyomyx, Inc. | Methods and reagents for surface functionalization |
US20040076961A1 (en) * | 2002-10-21 | 2004-04-22 | Lewis Mark A. | Biomolecule retaining material and methods for attaching biomolecules to a surface |
US7195908B2 (en) * | 2002-10-31 | 2007-03-27 | Corning Incorporated | Supports treated with triamine for immobilizing biomolecules |
JP4490413B2 (ja) | 2003-01-06 | 2010-06-23 | ネクター セラピューティクス アラバマ,コーポレイション | チオール選択的水溶性ポリマー誘導体 |
US20040151766A1 (en) * | 2003-01-30 | 2004-08-05 | Monahan Sean D. | Protein and peptide delivery to mammalian cells in vitro |
CA2522989A1 (en) * | 2003-05-21 | 2004-12-02 | Ares Trading S.A. | Method of chromatographic analysis of a protein solution |
US7135821B2 (en) * | 2003-10-01 | 2006-11-14 | Altera Corporation | High-definition cathode ray tube and electron gun |
US20050153320A1 (en) * | 2003-11-06 | 2005-07-14 | Herron James N. | Single base extension |
US8048437B2 (en) * | 2004-04-21 | 2011-11-01 | Richard Nagler | Medical device with surface coating comprising bioactive compound |
US7172906B2 (en) * | 2004-11-16 | 2007-02-06 | Dade Behring Inc. | Reduction of non-specific binding in assays |
JP5243041B2 (ja) | 2004-12-21 | 2013-07-24 | ネクター セラピューティックス | 安定化ポリマーチオール試薬 |
US20060147943A1 (en) * | 2004-12-30 | 2006-07-06 | Lewis Mark A | Substrates having pendant epoxide groups for binding biomolecules and methods of making and using thereof |
GB0507835D0 (en) * | 2005-04-18 | 2005-05-25 | Solexa Ltd | Method and device for nucleic acid sequencing using a planar wave guide |
US7743730B2 (en) * | 2005-12-21 | 2010-06-29 | Lam Research Corporation | Apparatus for an optimized plasma chamber grounded electrode assembly |
US20070225795A1 (en) * | 2006-03-24 | 2007-09-27 | Juan Granada | Composite vascular prosthesis |
EP2069790B1 (de) * | 2006-11-01 | 2015-04-29 | Beckman Coulter, Inc. | Bindungsoberflächen für affinitätstests |
EP2765125B1 (de) | 2007-01-24 | 2016-05-11 | Ethox Chemicals, Llc | Verfahren zur verbesserung von wassertransporteigenschaften hydrophober oberflächen |
US9107815B2 (en) * | 2008-02-22 | 2015-08-18 | Allergan, Inc. | Sustained release poloxamer containing pharmaceutical compositions |
EP3141905B1 (de) | 2008-03-27 | 2019-03-06 | Promega Corporation | Proteinetikettierung mit cyanbenzothiazol-konjugaten |
WO2010108985A1 (en) | 2009-03-25 | 2010-09-30 | Dsm Ip Assets B.V. | Improved anti-biofouling coating |
WO2010115243A1 (en) * | 2009-04-09 | 2010-10-14 | The University Of Queensland | Block copolymer blends |
US8623292B2 (en) | 2010-08-17 | 2014-01-07 | Kimberly-Clark Worldwide, Inc. | Dehydration sensors with ion-responsive and charged polymeric surfactants |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4264766A (en) * | 1877-09-19 | 1981-04-28 | Hoffmann-La Roche Inc. | Immunological diagnostic reagents |
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
SE420733B (sv) * | 1974-05-30 | 1981-10-26 | Exploaterings Ab Tbf | Gelprodukt, innehallande tiosulfatgrupper samt sett for framstellning derav |
US3966580A (en) * | 1974-09-16 | 1976-06-29 | The University Of Utah | Novel protein-immobilizing hydrophobic polymeric membrane, process for producing same and apparatus employing same |
SE430062B (sv) * | 1977-03-04 | 1983-10-17 | Pharmacia Fine Chemicals Ab | Kopplings- eller tioleringsreagens |
DE2850058A1 (de) * | 1978-11-18 | 1980-05-29 | Bayer Ag | Polyaether-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4259474A (en) * | 1979-09-25 | 1981-03-31 | Gaf Corporation | Sulfur-containing polyoxyalkylenes |
SE8102194L (sv) * | 1981-04-06 | 1982-10-07 | Pharmacia Ab | Terapeutiskt aktiv organisk forening och farmaceutisk beredning innehallande denna |
DE3380726D1 (en) * | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
DE3675588D1 (de) * | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
DE3532626A1 (de) * | 1985-09-12 | 1987-03-19 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung eines partners einer immunreaktion |
EP0263184B1 (de) * | 1986-03-28 | 1992-10-28 | Toray Industries, Inc. | Immobilisiertes, physiologisch aktives material |
IE64284B1 (en) * | 1987-08-03 | 1995-07-26 | Ddi Pharmaceuticals | Conjugates of superoxide dismutase |
US5006333A (en) * | 1987-08-03 | 1991-04-09 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US4929510A (en) * | 1988-04-29 | 1990-05-29 | State University Of New York | Biocompatible polymer articles |
JPH04502011A (ja) * | 1988-11-23 | 1992-04-09 | ジェネンテク,インコーポレイテッド | ポリペプチド誘導体 |
US5248820A (en) * | 1989-02-21 | 1993-09-28 | Pfizer Inc. | Crystalline N-(S-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, and processes and intermediates therefor |
US5219926A (en) * | 1989-12-29 | 1993-06-15 | Berol Nobel Ab | Method of covalently bonding biopolymer to a solid hydrophilic organic polymer |
DE4023671A1 (de) * | 1990-07-25 | 1992-01-30 | Boehringer Mannheim Gmbh | Nichtionische blockcopolymere aus propylenoxid und ethylenoxid |
JPH06506217A (ja) * | 1991-03-18 | 1994-07-14 | エンゾン,インコーポレーテッド | ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体 |
US5298643A (en) * | 1992-12-22 | 1994-03-29 | Enzon, Inc. | Aryl imidate activated polyalkylene oxides |
-
1993
- 1993-08-20 US US08/110,169 patent/US5516703A/en not_active Expired - Lifetime
-
1994
- 1994-08-22 DE DE69429345T patent/DE69429345T2/de not_active Expired - Lifetime
- 1994-08-22 WO PCT/US1994/009480 patent/WO1995006251A1/en active IP Right Grant
- 1994-08-22 EP EP94927206A patent/EP0701697B1/de not_active Expired - Lifetime
- 1994-08-22 CA CA002163519A patent/CA2163519C/en not_active Expired - Fee Related
-
1995
- 1995-03-07 US US08/399,913 patent/US5728588A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5516703A (en) | 1996-05-14 |
DE69429345D1 (de) | 2002-01-17 |
CA2163519C (en) | 2006-11-21 |
WO1995006251A1 (en) | 1995-03-02 |
EP0701697B1 (de) | 2001-12-05 |
EP0701697A4 (de) | 1996-07-10 |
US5728588A (en) | 1998-03-17 |
EP0701697A1 (de) | 1996-03-20 |
CA2163519A1 (en) | 1995-03-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |