DE69426598D1 - Neuartiges polypeptid mit einer inhibierenden aktivität gegen faktor xa - Google Patents

Neuartiges polypeptid mit einer inhibierenden aktivität gegen faktor xa

Info

Publication number
DE69426598D1
DE69426598D1 DE69426598T DE69426598T DE69426598D1 DE 69426598 D1 DE69426598 D1 DE 69426598D1 DE 69426598 T DE69426598 T DE 69426598T DE 69426598 T DE69426598 T DE 69426598T DE 69426598 D1 DE69426598 D1 DE 69426598D1
Authority
DE
Germany
Prior art keywords
polypeptide
innovative
activity against
against factor
deposited
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69426598T
Other languages
English (en)
Other versions
DE69426598T2 (de
Inventor
Elisha P Zeelon
Moshe M Werber
Avigdor Levanon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Savient Pharmaceuticals Inc
Original Assignee
Savient Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Savient Pharmaceuticals Inc filed Critical Savient Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69426598D1 publication Critical patent/DE69426598D1/de
Publication of DE69426598T2 publication Critical patent/DE69426598T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69426598T 1993-04-09 1994-04-08 Neues Peptid mit einer inhibierenden Aktivität gegen Faktor Xa Expired - Fee Related DE69426598T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4580593A 1993-04-09 1993-04-09
PCT/US1994/003871 WO1994023735A1 (en) 1993-04-09 1994-04-08 Novel polypeptide having factor xa inhibitory activity

Publications (2)

Publication Number Publication Date
DE69426598D1 true DE69426598D1 (de) 2001-02-22
DE69426598T2 DE69426598T2 (de) 2001-08-09

Family

ID=21939985

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69426598T Expired - Fee Related DE69426598T2 (de) 1993-04-09 1994-04-08 Neues Peptid mit einer inhibierenden Aktivität gegen Faktor Xa

Country Status (15)

Country Link
EP (1) EP0696198B1 (de)
JP (1) JPH08511157A (de)
KR (1) KR960701649A (de)
AT (1) ATE198710T1 (de)
AU (1) AU682361B2 (de)
CA (1) CA2159218A1 (de)
DE (1) DE69426598T2 (de)
DK (1) DK0696198T3 (de)
ES (1) ES2155472T3 (de)
GR (1) GR3035722T3 (de)
HK (1) HK1013315A1 (de)
IL (1) IL109259A0 (de)
NZ (1) NZ265507A (de)
PT (1) PT696198E (de)
WO (1) WO1994023735A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1264575C (zh) 1998-08-06 2006-07-19 山景药品公司 聚乙二醇或聚环氧乙烷－尿酸氧化酶结合物及其应用
MX2007012548A (es) 2005-04-11 2008-03-11 Savient Pharmaceuticals Inc Formas variantes de urato oxidasa y uso de las mismas.
KR20080009111A (ko) 2005-04-11 2008-01-24 새비언트 파마수티컬즈 인크. 유레이트 옥시다아제의 변이형 및 이의 용도
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
ES2532804T3 (es) 2006-04-12 2015-03-31 Crealta Pharmaceuticals Llc Purificación de proteínas con tensioactivo catiónico
MX347903B (es) 2009-06-25 2017-05-18 Crealta Pharmaceuticals Llc Metodos y equipos para predecir el riesgo de reaccion a la infusion y perdida de respuesta mediada por anticuerpos al supervisar el acido urico en suero durante una terapia con uricasa conjugada con peg.
US8501241B1 (en) 2012-09-17 2013-08-06 Biopep Solutions, Inc. Treating cancer with a whole, leech saliva extract

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588587A (en) * 1983-03-01 1986-05-13 Pennsylvania Hospital Method of treatment to inhibit metastasis
DE58907266T2 (de) * 1988-06-11 1994-09-29 Ciba Geigy Ag Polypeptide mit einer die Koagulierung hemmenden Wirkung.
US4832849A (en) * 1988-06-16 1989-05-23 Merrell Dow Pharmaceuticals Inc. Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii
IL86856A0 (en) * 1988-06-24 1988-11-30 Yissum Res Dev Co Bovine xa factor and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
KR960701649A (ko) 1996-03-28
GR3035722T3 (en) 2001-07-31
ATE198710T1 (de) 2001-02-15
EP0696198A1 (de) 1996-02-14
AU6629194A (en) 1994-11-08
NZ265507A (en) 1998-09-24
JPH08511157A (ja) 1996-11-26
CA2159218A1 (en) 1994-10-27
IL109259A0 (en) 1994-07-31
DE69426598T2 (de) 2001-08-09
EP0696198A4 (de) 1999-01-27
DK0696198T3 (da) 2001-08-06
AU682361B2 (en) 1997-10-02
EP0696198B1 (de) 2001-01-17
ES2155472T3 (es) 2001-05-16
WO1994023735A1 (en) 1994-10-27
HK1013315A1 (en) 1999-08-20
PT696198E (pt) 2001-07-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee