DE69419365D1 - Arzneizusammensetzung mit verzögerter Wirkstoffabgabe enthaltend eine Gallensäure als Wirkstoff - Google Patents

Arzneizusammensetzung mit verzögerter Wirkstoffabgabe enthaltend eine Gallensäure als Wirkstoff

Info

Publication number
DE69419365D1
DE69419365D1 DE69419365T DE69419365T DE69419365D1 DE 69419365 D1 DE69419365 D1 DE 69419365D1 DE 69419365 T DE69419365 T DE 69419365T DE 69419365 T DE69419365 T DE 69419365T DE 69419365 D1 DE69419365 D1 DE 69419365D1
Authority
DE
Germany
Prior art keywords
active ingredient
bile acid
delayed release
medicament composition
ingredient containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69419365T
Other languages
English (en)
Other versions
DE69419365T2 (de
Inventor
Fabio Borella
Alberto Brandt
Fabio Carli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Biochimico Italiano Giovanni Lorenzini SpA
Original Assignee
ISTITUTO BIOCHIMICO ITALIANO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISTITUTO BIOCHIMICO ITALIANO filed Critical ISTITUTO BIOCHIMICO ITALIANO
Publication of DE69419365D1 publication Critical patent/DE69419365D1/de
Application granted granted Critical
Publication of DE69419365T2 publication Critical patent/DE69419365T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69419365T 1993-05-18 1994-05-02 Arzneizusammensetzung mit verzögerter Wirkstoffabgabe enthaltend eine Gallensäure als Wirkstoff Expired - Fee Related DE69419365T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93MI001014A IT1265074B1 (it) 1993-05-18 1993-05-18 Composizione farmaceutica a lento rilascio contenente come sostanza attiva un acido biliare

Publications (2)

Publication Number Publication Date
DE69419365D1 true DE69419365D1 (de) 1999-08-12
DE69419365T2 DE69419365T2 (de) 2000-03-30

Family

ID=11366211

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69419365T Expired - Fee Related DE69419365T2 (de) 1993-05-18 1994-05-02 Arzneizusammensetzung mit verzögerter Wirkstoffabgabe enthaltend eine Gallensäure als Wirkstoff

Country Status (5)

Country Link
US (1) US5510114A (de)
EP (1) EP0625353B1 (de)
DE (1) DE69419365T2 (de)
ES (1) ES2136139T3 (de)
IT (1) IT1265074B1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US6368586B1 (en) 1996-01-26 2002-04-09 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
UA69413C2 (uk) * 1998-05-22 2004-09-15 Брістол-Майерс Сквібб Компані Фармацевтична композиція, яка містить серцевину та ентеросолюбільну оболонку, фармацевтична композиція у вигляді сфероїдальних гранул, спосіб одержання сфероїдальних гранул та спосіб одержання фармацевтичної композиції
US7122207B2 (en) 1998-05-22 2006-10-17 Bristol-Myers Squibb Company High drug load acid labile pharmaceutical composition
UA73092C2 (uk) 1998-07-17 2005-06-15 Брістол-Майерс Сквібб Компані Таблетка з ентеросолюбільним покриттям і спосіб її приготування
DE19906290A1 (de) * 1999-02-15 2000-08-17 Falk Pharma Gmbh Arzneimittel zur Behandlung bzw. Prävention von Darmkrebs
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
ES2162746B1 (es) * 1999-10-21 2003-02-16 Lipotec Sa Microcapsulas para la estabilizacion de productos cosmeticos, farmaceuticos o de alimentacion.
AR030557A1 (es) * 2000-04-14 2003-08-27 Jagotec Ag Una tableta en multicapa de liberacion controlada y metodo de tratamiento
ZA200711123B (en) 2005-06-27 2009-08-26 Biovail Lab Int Srl Modified-release formulations of a bupropion salt
US8119162B2 (en) * 2005-11-10 2012-02-21 Colgate-Palmolive Company Particles that disrupt or impede bacterial adhesion, related compositions and methods
US20090246276A1 (en) 2008-01-28 2009-10-01 Graham Jackson Pharmaceutical Compositions
US20100233259A1 (en) * 2008-12-12 2010-09-16 Pascal Grenier Dosage form of ropinirole
US9301911B2 (en) * 2012-01-06 2016-04-05 Daewoong Pharmaceutical Co., Ltd. Composition comprising tauroursodeoxycholic acid
EP3703724A1 (de) 2017-11-02 2020-09-09 NatureCeuticals Sdn. Bhd. Extrakt aus orthosiphon stamineus, formulierungen und verwendungen davon

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2918411A (en) * 1957-11-01 1959-12-22 Olin Mathieson Pharmaceutical preparations
IT1101649B (it) * 1978-12-15 1985-10-07 Lehner Ag Composizione farmaceutica ad azione prolungata contenente acidi biliari
DK151608C (da) * 1982-08-13 1988-06-20 Benzon As Alfred Fremgangsmaade til fremstilling af et farmaceutisk peroralt polydepotpraeparat med kontrolleret afgivelse
IT1249686B (it) * 1991-07-22 1995-03-09 Boniscontro E Gazzone S R L Preparazioni farmaceutiche orali, a base di acidi biliari, a cessione protratta e controllata con le quali e' possibile adottare una sola somministrazione giornaliera
IT1251153B (it) * 1991-08-06 1995-05-04 Vectorpharma Int Composizioni farmaceutiche solide per somministrazione orale aventi proungata residenza gastrica
US5262172A (en) * 1992-06-19 1993-11-16 Digestive Care Inc. Compositions of gastric acid-resistant microspheres containing buffered bile acids

Also Published As

Publication number Publication date
ITMI931014A0 (it) 1993-05-18
US5510114A (en) 1996-04-23
ITMI931014A1 (it) 1994-11-18
EP0625353B1 (de) 1999-07-07
IT1265074B1 (it) 1996-10-30
EP0625353A1 (de) 1994-11-23
ES2136139T3 (es) 1999-11-16
DE69419365T2 (de) 2000-03-30

Similar Documents

Publication Publication Date Title
DE69419365D1 (de) Arzneizusammensetzung mit verzögerter Wirkstoffabgabe enthaltend eine Gallensäure als Wirkstoff
DE69434479D1 (de) Tramadolhaltiges Arzneimittel mit gesteuerter Wirkstoffabgabe
EP0731712A4 (de) Physiologisch stabile butlersäurepräparate, und butlersäuresalze und -derivate als antineoplastische wirkstoff
IE940583L (en) Topical antimicrobial pharmaceutical compositions
IL105035A0 (en) Substituted pipecolinic acid derivatives,their preparation and pharmaceutical compositions containing them
DE69409969T2 (de) Salze der mehrfach ungesättigten fettsäuren und diese enthaltende pharmazeutischen zusammensetzungen
DE69000881D1 (de) 2-propylvaleriansaeure enthaltende arzneizubereitung mit verzoegerter wirkstofffreigabe.
DE69323442T2 (de) Flüssige pharmazeutische Formulierung mit verlängerter Wirkstoffabgabe
DK98088A (da) Farmaceutisk formulering med forsinket frigivelse af den aktive bestanddel
DE59003337D1 (de) Pressling mit retardierter Wirkstofffreisetzung.
EP0440809A4 (en) Methylenediphosphonic acid compound and anti-inflammatory containing the same as active ingredient
ATE220547T1 (de) Arzneimittelformulierung mit kontrollierter wirkstofffreisetzung
IL111252A0 (en) Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient,and intermediate compound for use in production of said dihalopropene compound
AU3176695A (en) Transdermally active pharmaceutical composition containing 5-aminolaevulinic acid
IL111152A0 (en) Retinoic acid esters, their preparation and pharmaceutical or cosmetic compositions containing them
DE69518193D1 (de) Präparat mit verzörgerter Wirkstoffabgabe
ITMI932193A0 (it) Composti ad attivita' antiistaminica per la loro preparazione e composizioni farmaceutiche che li contengono
KR950700743A (ko) 프로스타사이클린류를 활성성분으로서 함유하는 외용 피부치료제 조성물(dermatologic preparation composition containing prostacyclin as active ingredient)
IL109140A0 (en) Herbicidal compositions containing salicylic acid derivatives and antidote compounds
EP0489933A4 (en) Bile alcohol and drug containing the same as active ingredient
HU9802896D0 (en) Optically active piperidinoalkyl-4h-1,2,4-oxadiazine derivative, the use thereof in the treatment of vascular diseases and pharmaceutical composition containing the compound as active ingredient
IT1229519B (it) Composizione farmaceutica comprendente come ingrediente attivo 3-(n-piperidinometil- azino) metilrifamicina s
GB8905489D0 (en) Pharmaceutical composition comprising 3-(n-piperidino-azino)methylrifamycins as active ingredient
IL100552A0 (en) Biocidal composition containing aliphatic and hydroxyaliphatic acid
NO932008D0 (no) Prokatalysatorsammensetning inneholdende substituerte malein- eller fumarsyreestere som elektrondonor for olefinpolymerisasjon

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: IBI-ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZIN

8328 Change in the person/name/address of the agent

Representative=s name: SEITZ, R., DIPL.-ING.UNIV., PAT.-ANW., 80538 MUENC

8339 Ceased/non-payment of the annual fee