DE69415672D1 - Azolyl-cyclische aminderivate mit immunomodulierender wirkung - Google Patents

Azolyl-cyclische aminderivate mit immunomodulierender wirkung

Info

Publication number
DE69415672D1
DE69415672D1 DE69415672T DE69415672T DE69415672D1 DE 69415672 D1 DE69415672 D1 DE 69415672D1 DE 69415672 T DE69415672 T DE 69415672T DE 69415672 T DE69415672 T DE 69415672T DE 69415672 D1 DE69415672 D1 DE 69415672D1
Authority
DE
Germany
Prior art keywords
azolyl
cyclic amine
amine derivatives
immunomodulating effect
immunomodulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69415672T
Other languages
English (en)
Other versions
DE69415672T2 (de
Inventor
David Webber
Gerald Tometzki
Michael Hockley
Roger Titman
Roy Davies
Paul Bradley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll GmbH filed Critical Knoll GmbH
Application granted granted Critical
Publication of DE69415672D1 publication Critical patent/DE69415672D1/de
Publication of DE69415672T2 publication Critical patent/DE69415672T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69415672T 1993-06-22 1994-06-10 Azolyl-cyclische aminderivate mit immunomodulierender wirkung Expired - Fee Related DE69415672T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939312806A GB9312806D0 (en) 1993-06-22 1993-06-22 Therapeutic agents
PCT/EP1994/001925 WO1995000507A1 (en) 1993-06-22 1994-06-10 Azolyl-cyclic amine derivatives with immunomodulatory activity

Publications (2)

Publication Number Publication Date
DE69415672D1 true DE69415672D1 (de) 1999-02-11
DE69415672T2 DE69415672T2 (de) 1999-05-20

Family

ID=10737539

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69415672T Expired - Fee Related DE69415672T2 (de) 1993-06-22 1994-06-10 Azolyl-cyclische aminderivate mit immunomodulierender wirkung

Country Status (7)

Country Link
EP (1) EP0705258B1 (de)
JP (1) JPH08511548A (de)
AU (1) AU7185094A (de)
DE (1) DE69415672T2 (de)
GB (1) GB9312806D0 (de)
IL (1) IL110028A0 (de)
WO (1) WO1995000507A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0862435A4 (de) * 1995-11-22 1999-02-03 Merck & Co Inc Inhibitoren der farnesyl-protein-transferase
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
EP1058683B1 (de) * 1998-02-02 2002-12-04 Lg Chemical Limited Farnesyltransferase-inhibitoren mit piperidinstruktur und verfahren zu ihrer herstellung
EP1564213A4 (de) * 2002-11-22 2009-05-27 Takeda Pharmaceutical Imidazolderivat, verfahren zu dessenherstellung und verwendung
JP4932135B2 (ja) * 2002-11-22 2012-05-16 武田薬品工業株式会社 イミダゾール誘導体、その製造法及び用途
TWI396686B (zh) 2004-05-21 2013-05-21 Takeda Pharmaceutical 環狀醯胺衍生物、以及其製品和用法
WO2010068794A2 (en) 2008-12-10 2010-06-17 The General Hospital Corporation Hif inhibitors and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0029707B1 (de) * 1979-11-21 1984-02-01 Kyowa Hakko Kogyo Co., Ltd Piperidinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPS58180481A (ja) * 1982-04-15 1983-10-21 Kyowa Hakko Kogyo Co Ltd 新規なピペリジン誘導体
FR2665160A1 (fr) * 1990-07-26 1992-01-31 Esteve Labor Dr Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments.
GB9021535D0 (en) * 1990-10-03 1990-11-14 Wyeth John & Brother Ltd Piperazine derivatives
HUT64320A (en) * 1990-12-14 1993-12-28 Merrell Dow Pharma Process for production antiallergic imidazole derivatives and pharmaceutical preparations containing these compounds

Also Published As

Publication number Publication date
JPH08511548A (ja) 1996-12-03
AU7185094A (en) 1995-01-17
WO1995000507A1 (en) 1995-01-05
DE69415672T2 (de) 1999-05-20
GB9312806D0 (en) 1993-08-04
EP0705258A1 (de) 1996-04-10
IL110028A0 (en) 1994-11-11
EP0705258B1 (de) 1998-12-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ABBOTT GMBH & CO. KG, 65205 WIESBADEN, DE

8339 Ceased/non-payment of the annual fee