DE69410814T2 - Synthese von sphingosinen - Google Patents

Synthese von sphingosinen

Info

Publication number
DE69410814T2
DE69410814T2 DE69410814T DE69410814T DE69410814T2 DE 69410814 T2 DE69410814 T2 DE 69410814T2 DE 69410814 T DE69410814 T DE 69410814T DE 69410814 T DE69410814 T DE 69410814T DE 69410814 T2 DE69410814 T2 DE 69410814T2
Authority
DE
Germany
Prior art keywords
sphingosine
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69410814T
Other languages
English (en)
Other versions
DE69410814D1 (de
Inventor
Tomas Hudlicky
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virginia Tech Intellectual Properties Inc
Original Assignee
Virginia Tech Intellectual Properties Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virginia Tech Intellectual Properties Inc filed Critical Virginia Tech Intellectual Properties Inc
Publication of DE69410814D1 publication Critical patent/DE69410814D1/de
Application granted granted Critical
Publication of DE69410814T2 publication Critical patent/DE69410814T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69410814T 1993-10-18 1994-10-11 Synthese von sphingosinen Expired - Lifetime DE69410814T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13734693A 1993-10-18 1993-10-18
PCT/US1994/011540 WO1995011222A1 (en) 1993-10-18 1994-10-11 Synthesis of sphingosines

Publications (2)

Publication Number Publication Date
DE69410814D1 DE69410814D1 (de) 1998-07-09
DE69410814T2 true DE69410814T2 (de) 1998-11-12

Family

ID=22476987

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69410814T Expired - Lifetime DE69410814T2 (de) 1993-10-18 1994-10-11 Synthese von sphingosinen

Country Status (7)

Country Link
US (2) US5488166A (de)
EP (1) EP0724562B1 (de)
JP (2) JP3783730B2 (de)
CA (1) CA2174431C (de)
DE (1) DE69410814T2 (de)
ES (1) ES2117304T3 (de)
WO (1) WO1995011222A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6720184B1 (en) 1991-08-05 2004-04-13 Emory University Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination
FR2727407B1 (fr) * 1994-11-30 1996-12-27 Oreal Procede de preparation de 2-amino-alcane-1,3-diols
US6232299B1 (en) 1996-05-01 2001-05-15 Eli Lilly And Company Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy
WO1999041266A1 (en) * 1998-02-12 1999-08-19 Emory University Sphingolipid derivatives and their methods of use
WO1999066936A1 (en) 1998-06-24 1999-12-29 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
US20040175384A1 (en) * 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
US8592368B2 (en) 2003-12-19 2013-11-26 University Of South Florida JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
CA2622867A1 (en) 2005-09-16 2007-03-22 Schering Corporation Pharmaceutical compositions and methods using temozolomide and a protein kinase inhibitor
WO2008030840A2 (en) * 2006-09-06 2008-03-13 Emory University Synthesis of sphingosines and their derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0651715B2 (ja) * 1985-06-07 1994-07-06 理化学研究所 シアロシルセレブロシド類及びその製造法
DE3683214D1 (de) * 1985-08-13 1992-02-13 Solco Basel Ag Neues verfahren zur herstellung von sphingosinderivaten.
US5010059A (en) * 1987-06-26 1991-04-23 Solco Basel Ag Pharmaceutical products and lactosyl compounds
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
US5110987A (en) * 1988-06-17 1992-05-05 Emory University Method of preparing sphingosine derivatives
US5012000A (en) * 1989-10-30 1991-04-30 Eastman Kodak Company Total synthesis of chiral 2-amino-1,3-diols
US5068345A (en) * 1989-10-30 1991-11-26 Eastman Kodak Company Oxazolidinone aldol adduct
US5200516A (en) * 1990-02-16 1993-04-06 Virginia Tech Intellectual Properties Synthesis of sugars from substituted and unsubstituted arene diols
US5151360A (en) * 1990-12-31 1992-09-29 Biomembrane Institute Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation
US5137919A (en) * 1990-12-31 1992-08-11 Biomembrane Institute Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
US5220043A (en) * 1991-03-21 1993-06-15 Ohio University Synthesis of D-erythro-sphingomyelins

Also Published As

Publication number Publication date
JP4224049B2 (ja) 2009-02-12
EP0724562A1 (de) 1996-08-07
DE69410814D1 (de) 1998-07-09
JP2006028196A (ja) 2006-02-02
WO1995011222A1 (en) 1995-04-27
ES2117304T3 (es) 1998-08-01
JP3783730B2 (ja) 2006-06-07
CA2174431C (en) 2005-12-06
US5488167A (en) 1996-01-30
JPH09503786A (ja) 1997-04-15
CA2174431A1 (en) 1995-04-27
US5488166A (en) 1996-01-30
EP0724562B1 (de) 1998-06-03

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Legal Events

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