DE69332120T2 - Verwendung von mit polysacchariden überzogenen superparamagnetischen oxid-kolloiden - Google Patents

Verwendung von mit polysacchariden überzogenen superparamagnetischen oxid-kolloiden

Info

Publication number
DE69332120T2
DE69332120T2 DE69332120T DE69332120T DE69332120T2 DE 69332120 T2 DE69332120 T2 DE 69332120T2 DE 69332120 T DE69332120 T DE 69332120T DE 69332120 T DE69332120 T DE 69332120T DE 69332120 T2 DE69332120 T2 DE 69332120T2
Authority
DE
Germany
Prior art keywords
polysaccharides
covered
oxide colloids
superparamagnetic oxide
superparamagnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332120T
Other languages
English (en)
Other versions
DE69332120D1 (de
Inventor
Stephen Palmacci
Lee Josephson
V Groman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amag Pharmaceuticals Inc
Original Assignee
Advanced Magnetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Magnetics Inc filed Critical Advanced Magnetics Inc
Publication of DE69332120D1 publication Critical patent/DE69332120D1/de
Application granted granted Critical
Publication of DE69332120T2 publication Critical patent/DE69332120T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/44—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
    • H01F1/445—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids the magnetic component being a compound, e.g. Fe3O4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1809—Micelles, e.g. phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Power Engineering (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DE69332120T 1993-08-12 1993-08-12 Verwendung von mit polysacchariden überzogenen superparamagnetischen oxid-kolloiden Expired - Lifetime DE69332120T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1993/007682 WO1995005669A1 (en) 1993-08-12 1993-08-12 Synthesis of polysaccharide covered superparamagnetic oxide colloids

Publications (2)

Publication Number Publication Date
DE69332120D1 DE69332120D1 (de) 2002-08-22
DE69332120T2 true DE69332120T2 (de) 2003-02-27

Family

ID=22236855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332120T Expired - Lifetime DE69332120T2 (de) 1993-08-12 1993-08-12 Verwendung von mit polysacchariden überzogenen superparamagnetischen oxid-kolloiden

Country Status (4)

Country Link
EP (1) EP0713602B1 (de)
JP (1) JP3854631B2 (de)
DE (1) DE69332120T2 (de)
WO (1) WO1995005669A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691423A (en) * 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US6986942B1 (en) 1996-11-16 2006-01-17 Nanomagnetics Limited Microwave absorbing structure
DE19808079A1 (de) * 1998-02-20 1999-08-26 Schering Ag Hydroxyethylstärke-Konjugate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US6361759B1 (en) 1998-05-26 2002-03-26 Wisconsin Alumni Research Foundation MR signal-emitting coatings
US6896874B2 (en) * 1998-05-26 2005-05-24 Wisconsin Alumni Research Foundation MR-signal emitting coatings
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
US7082326B2 (en) 2000-03-31 2006-07-25 Amersham Health As Method of magnetic resonance imaging
FR2808026B1 (fr) * 2000-04-25 2002-06-14 Alexandre Laurent Biomateriau a base de polymere hydrophile presentant un signal specifique en imagerie par resonance magnetique et procede de preparation d'un tel biomateriau
JP3728411B2 (ja) * 2001-09-18 2005-12-21 ソニー株式会社 磁性粒子の作製方法、磁性粒子および磁性材料
JP2005531647A (ja) * 2002-04-11 2005-10-20 カルボマー インク 新規なイメージングプローブ
JP2005531648A (ja) * 2002-04-11 2005-10-20 カルボマー インク 生体適合性物質およびプローブ類
GB2393728A (en) * 2002-10-04 2004-04-07 Nanomagnetics Ltd Magnetic nanoparticles
WO2005087367A1 (ja) * 2004-03-15 2005-09-22 Hitachi Maxell, Ltd. 磁性複合粒子およびその製造方法
US8457712B2 (en) 2005-12-30 2013-06-04 Wisconsin Alumni Research Foundation Multi-mode medical device system and methods of manufacturing and using same
US8532742B2 (en) 2006-11-15 2013-09-10 Wisconsin Alumni Research Foundation System and method for simultaneous 3DPR device tracking and imaging under MR-guidance for therapeutic endovascular interventions
JP5353004B2 (ja) * 2007-01-05 2013-11-27 国立大学法人東京工業大学 球形フェライトナノ粒子の製造方法
US20080208039A1 (en) 2007-02-28 2008-08-28 Wisconsin Alumni Research Foundation System and method of performing therapeutic endovascular interventions
KR101125232B1 (ko) * 2009-09-29 2012-03-21 서울대학교산학협력단 초상자성 산화철 나노입자 탑재 고분자 미세구의 제조 방법
DE102011112898A1 (de) * 2011-09-08 2013-03-14 Charité - Universitätsmedizin Berlin Nanopartikuläres Phosphatadsorbens basierend auf Maghämit oder Maghämit/Magnetit, dessen Herstellung und Verwendungen
EP3849619A1 (de) 2018-09-10 2021-07-21 Saving Patients' Lives Medical B.V. Ultrakleine superparamagnetische eisenoxidnanopartikel
CN113304270B (zh) * 2021-05-18 2023-10-24 广州康臣药业有限公司 水溶性磁球的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4824587A (en) * 1985-03-18 1989-04-25 The Dow Chemical Company Composites of coercive particles and superparamagnetic particles
US4827945A (en) * 1986-07-03 1989-05-09 Advanced Magnetics, Incorporated Biologically degradable superparamagnetic materials for use in clinical applications
JPH03141119A (ja) * 1989-10-25 1991-06-17 Nippon Telegr & Teleph Corp <Ntt> 磁性微粒子の製造方法
ES2130406T5 (es) * 1992-08-05 2003-12-16 Meito Sangyo Kk Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.
US5349957A (en) * 1992-12-02 1994-09-27 Sterling Winthrop Inc. Preparation and magnetic properties of very small magnetite-dextran particles

Also Published As

Publication number Publication date
DE69332120D1 (de) 2002-08-22
EP0713602A1 (de) 1996-05-29
EP0713602B1 (de) 2002-07-17
WO1995005669A1 (en) 1995-02-23
JPH09501675A (ja) 1997-02-18
JP3854631B2 (ja) 2006-12-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AMAG PHARMACEUTICALS,INC.(N.D.GES.D.STAATES DE, US