DE69026930T2 - Organisch magnetischer verbundstoff - Google Patents

Organisch magnetischer verbundstoff

Info

Publication number
DE69026930T2
DE69026930T2 DE69026930T DE69026930T DE69026930T2 DE 69026930 T2 DE69026930 T2 DE 69026930T2 DE 69026930 T DE69026930 T DE 69026930T DE 69026930 T DE69026930 T DE 69026930T DE 69026930 T2 DE69026930 T2 DE 69026930T2
Authority
DE
Germany
Prior art keywords
magnetic composite
organic magnetic
organic
composite
magnetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69026930T
Other languages
English (en)
Other versions
DE69026930D1 (de
Inventor
Shigeo Maruno
Masakatsu Hasegawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meito Sangyo KK
Original Assignee
Meito Sangyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meito Sangyo KK filed Critical Meito Sangyo KK
Application granted granted Critical
Publication of DE69026930D1 publication Critical patent/DE69026930D1/de
Publication of DE69026930T2 publication Critical patent/DE69026930T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1863—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being a polysaccharide or derivative thereof, e.g. chitosan, chitin, cellulose, pectin, starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/20—Oxides; Hydroxides
    • C08K3/22—Oxides; Hydroxides of metals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Hard Magnetic Materials (AREA)
  • Soft Magnetic Materials (AREA)
DE69026930T 1989-10-20 1990-10-19 Organisch magnetischer verbundstoff Expired - Lifetime DE69026930T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1271784A JP2726520B2 (ja) 1989-10-20 1989-10-20 有機磁性複合体
PCT/JP1990/001346 WO1991005807A1 (en) 1989-10-20 1990-10-19 Organic magnetic composite

Publications (2)

Publication Number Publication Date
DE69026930D1 DE69026930D1 (de) 1996-06-13
DE69026930T2 true DE69026930T2 (de) 1996-09-12

Family

ID=17504803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69026930T Expired - Lifetime DE69026930T2 (de) 1989-10-20 1990-10-19 Organisch magnetischer verbundstoff

Country Status (5)

Country Link
US (1) US5204457A (de)
EP (1) EP0450092B1 (de)
JP (1) JP2726520B2 (de)
DE (1) DE69026930T2 (de)
WO (1) WO1991005807A1 (de)

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JP2921984B2 (ja) * 1991-01-19 1999-07-19 名糖産業株式会社 磁性金属酸化物超微粒子含有組成物
DK0526649T3 (da) * 1991-02-21 1998-10-07 Drug Delivery System Inst Ltd Carboxymethylmannoglucan og derivater deraf.
DE69223748T2 (de) * 1991-06-11 1998-04-23 Meito Sangyo Kk Oxidierte zusammensetzung, enthaltend ein wasserlösliches carboxypolysaccharid und magnetisches eisenoxid
ES2130406T5 (es) † 1992-08-05 2003-12-16 Meito Sangyo Kk Material compuesto de pequeño diametro compuesto de carboxipolisacarido soluble en agua y oxido de hierro magnetico.
US5349957A (en) * 1992-12-02 1994-09-27 Sterling Winthrop Inc. Preparation and magnetic properties of very small magnetite-dextran particles
DE4428851C2 (de) * 1994-08-04 2000-05-04 Diagnostikforschung Inst Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie
US6048920A (en) 1994-08-15 2000-04-11 Xerox Corporation Magnetic nanocomposite compositions and processes for the preparation and use thereof
DK0783325T3 (da) * 1994-09-27 2000-05-01 Nycomed Imaging As Kontrastmiddel
CN1071580C (zh) * 1994-09-27 2001-09-26 尼科梅德成像有限公司 造影剂
US6165378A (en) * 1996-08-30 2000-12-26 Meito Sangyo Kabushiki Kaisha Polysaccharide derivative/magnetic metal oxide composite
EP1522318A3 (de) * 1999-04-09 2005-07-06 Advanced Magnetics Incorporated Hitzebeständige umhüllte kolloidale Eisenoxide
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
WO2000061191A2 (en) 1999-04-09 2000-10-19 Advanced Magnetics, Inc. Heat stable coated colloidal iron oxides
US7169618B2 (en) 2000-06-28 2007-01-30 Skold Technology Magnetic particles and methods of producing coated magnetic particles
ATE536993T1 (de) * 2002-01-02 2011-12-15 Visen Medical Inc Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten
DE60316748T2 (de) * 2002-06-27 2008-02-07 Toyo Boseki K.K. Magnetischer Träger für biologische Substanzen, Verfahren zur seiner Produktion und seiner Verwendung zur Isolierung dieser biologischen Substanzen
WO2004016316A1 (ja) * 2002-08-16 2004-02-26 Admetec Co., Ltd. 加熱方法及びそのための加熱装置
DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
WO2005103067A1 (en) 2004-04-23 2005-11-03 Novexin Limited Methods and kits for stabilising, protecting and solubilising proteins
US20060014938A1 (en) * 2004-07-14 2006-01-19 Groman Ernest V Stable aqueous colloidal lanthanide oxides
JP5321772B2 (ja) * 2005-06-15 2013-10-23 戸田工業株式会社 磁性粒子含有医薬用原薬
JP2006347949A (ja) * 2005-06-15 2006-12-28 Toda Kogyo Corp 磁性粒子含有医薬用原薬
WO2007027843A2 (en) * 2005-08-31 2007-03-08 T2 Biosystems, Inc. Nmr device for detection of analytes involving magnetic particles
US9913917B2 (en) 2005-12-22 2018-03-13 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
EP1973549B1 (de) 2006-01-06 2016-07-20 Luitpold Pharmaceuticals, Inc. Verfahren und zusammensetzungen zur eisenverabreichung
FR2918868A1 (fr) 2006-06-06 2009-01-23 Guerbet Sa Methode d'imagerie de diagnostic utilisant en combinaison avec l'imagerie de diffusion de l'eau, des agents de contraste
WO2008055523A1 (en) * 2006-11-07 2008-05-15 Stichting Dutch Polymer Institute Magnetic fluids and their use
CA2669045A1 (en) 2006-11-08 2008-05-15 T2 Biosystems, Inc. Nmr systems for in vivo detection of analytes
WO2008108505A1 (ja) 2007-03-07 2008-09-12 Japan As Represented By President Of International Medical Center Of Japan 新規核内移行ペプチド
WO2008121069A1 (en) 2007-03-29 2008-10-09 Swetree Technologies Ab Magnetic nanoparticle cellulose material
WO2009045354A1 (en) * 2007-09-28 2009-04-09 T2 Biosystems, Inc. Nmr diagnostics by means of a plastic sample container
EP2217951A4 (de) 2007-11-06 2011-05-18 T2 Biosystems Inc Kleiner magnet und hf-spule für die magnetresonanz-relaxometrie
WO2010051362A1 (en) 2008-10-29 2010-05-06 T2 Biosystems, Inc. Nmr detection of coagulation time
GB0912485D0 (en) 2009-07-17 2009-08-26 Polytherics Ltd Improved conjugation method
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
ES2576927T3 (es) 2010-10-22 2016-07-12 T2 Biosystems, Inc. Sistemas de RMN y métodos para la detección rápida de analitos
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
KR101642903B1 (ko) * 2011-02-09 2016-07-27 한화케미칼 주식회사 친수성 물질이 코팅된 산화철 나노입자의 제조방법 및 이를 이용하는 자기공명영상 조영제
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
AU2012281017B2 (en) 2011-07-13 2017-07-20 T2 Biosystems, Inc. NMR methods for monitoring blood clot formation
EP2748651B1 (de) 2011-09-21 2017-08-30 T2 Biosystems, Inc. Nmr-verfahren für endotoxinanalyse
WO2013158281A1 (en) 2012-04-20 2013-10-24 T2 Biosystems, Inc. Compositions and methods for detection of candida species
US9739733B2 (en) 2012-12-07 2017-08-22 T2 Biosystems, Inc. Methods for monitoring tight clot formation
EP3405479A4 (de) 2016-01-21 2019-08-21 T2 Biosystems, Inc. Nmr-verfahren und -systeme zur schnellen detektion von bakterien

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GB891770A (en) * 1958-09-30 1962-03-21 Ohio Commw Eng Co Iron carboxymethyl dextran
JPS5913521B2 (ja) * 1975-06-19 1984-03-30 メイトウサンギヨウ カブシキガイシヤ 磁性酸化鉄・デキストラン複合体の製造法
US4452773A (en) * 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
JPS5993097A (ja) * 1982-11-16 1984-05-29 Yamasa Shoyu Co Ltd ポリヌクレオチド複合体
JPS6017445B2 (ja) * 1982-12-28 1985-05-02 ダイセル化学工業株式会社 酸型カルボキシメチルセルロ−ス
SE465907B (sv) * 1984-11-01 1991-11-18 Nyegaard & Co As Diagnosticeringsmedel innehaallande en paramagnetisk metall
PT81498B (pt) * 1984-11-23 1987-12-30 Schering Ag Processo para a preparacao de composicoes para diagnostico contendo particulas magneticas

Also Published As

Publication number Publication date
JP2726520B2 (ja) 1998-03-11
EP0450092B1 (de) 1996-05-08
JPH03134001A (ja) 1991-06-07
US5204457A (en) 1993-04-20
EP0450092A4 (en) 1992-12-09
WO1991005807A1 (en) 1991-05-02
EP0450092A1 (de) 1991-10-09
DE69026930D1 (de) 1996-06-13

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