DE69328092T2 - Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial - Google Patents

Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial

Info

Publication number
DE69328092T2
DE69328092T2 DE69328092T DE69328092T DE69328092T2 DE 69328092 T2 DE69328092 T2 DE 69328092T2 DE 69328092 T DE69328092 T DE 69328092T DE 69328092 T DE69328092 T DE 69328092T DE 69328092 T2 DE69328092 T2 DE 69328092T2
Authority
DE
Germany
Prior art keywords
plasminogen activator
cytotoxic
providing
way
connection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69328092T
Other languages
English (en)
Other versions
DE69328092D1 (de
Inventor
Jerzy Jankun
Richard Hart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toledo
Original Assignee
University of Toledo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Toledo filed Critical University of Toledo
Publication of DE69328092D1 publication Critical patent/DE69328092D1/de
Application granted granted Critical
Publication of DE69328092T2 publication Critical patent/DE69328092T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE69328092T 1992-05-28 1993-05-27 Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial Expired - Fee Related DE69328092T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88978392A 1992-05-28 1992-05-28
US5981393A 1993-05-10 1993-05-10
PCT/US1993/005034 WO1993024141A1 (en) 1992-05-28 1993-05-27 Delivery of a cytotoxic compound to a cancer cell using a pathway of plasminogen activator material

Publications (2)

Publication Number Publication Date
DE69328092D1 DE69328092D1 (de) 2000-04-20
DE69328092T2 true DE69328092T2 (de) 2000-07-20

Family

ID=26739215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69328092T Expired - Fee Related DE69328092T2 (de) 1992-05-28 1993-05-27 Bereitstellung einer für krebszellen cytotoxischen verbindung unter verwendung des weges von plasminogenaktivatormaterial

Country Status (6)

Country Link
EP (1) EP0643584B1 (de)
AT (1) ATE190501T1 (de)
AU (1) AU4394293A (de)
DE (1) DE69328092T2 (de)
ES (1) ES2143504T3 (de)
WO (1) WO1993024141A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001519647A (ja) * 1995-12-28 2001-10-23 カイロン コーポレイション 標的細胞中へのウイルスおよび粒子の取り込みおよびインターナリゼーションのためのレセプター特異的キメラウイルス表面ポリペプチド
US6277818B1 (en) 1998-10-29 2001-08-21 Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
US5994309A (en) 1997-07-25 1999-11-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions and methods
JP2008501624A (ja) * 2003-11-18 2008-01-24 アテニュオン， エルエルシー ウロキナーゼのアミノ末端断片と結合する抗体および／または抗体コンジュゲート、その組成物ならびに使用
US20070190068A1 (en) * 2005-10-10 2007-08-16 Richard Hart uPAR-binding molecule-drug conjugates and uses thereof
PT2117571T (pt) 2006-12-08 2017-06-14 Monopar Therapeutics Inc Resumo
US8877156B2 (en) 2007-06-26 2014-11-04 New York University Contrast agents anchored by thiols on nanoparticles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN165717B (de) * 1986-08-07 1989-12-23 Battelle Memorial Institute
EP0467932B1 (de) * 1989-04-07 2000-10-18 Cancerforskningsfonden af 1989 (fonden til fremme af eksperimentel cancerforskning) Plasminogen-aktivator-rezeptor vom urokinasetyp

Also Published As

Publication number Publication date
AU4394293A (en) 1993-12-30
EP0643584A1 (de) 1995-03-22
DE69328092D1 (de) 2000-04-20
EP0643584B1 (de) 2000-03-15
WO1993024141A1 (en) 1993-12-09
EP0643584A4 (de) 1995-07-26
ES2143504T3 (es) 2000-05-16
ATE190501T1 (de) 2000-04-15

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Legal Events

Date Code Title Description
8328 Change in the person/name/address of the agent

Free format text: PATENTANWAELTE RUFF, WILHELM, BEIER, DAUSTER & PARTNER, 70173 STUTTGART

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee