DE69327312T2 - Deazaaminopterine für behandlung von entzündungen - Google Patents

Deazaaminopterine für behandlung von entzündungen

Info

Publication number
DE69327312T2
DE69327312T2 DE69327312T DE69327312T DE69327312T2 DE 69327312 T2 DE69327312 T2 DE 69327312T2 DE 69327312 T DE69327312 T DE 69327312T DE 69327312 T DE69327312 T DE 69327312T DE 69327312 T2 DE69327312 T2 DE 69327312T2
Authority
DE
Germany
Prior art keywords
deazaaminopterine
treating inflammation
inflammation
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69327312T
Other languages
English (en)
Other versions
DE69327312D1 (de
Inventor
James Piper
Joseph Degraw
William Colwell
Francis Sirotnak
R Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of DE69327312D1 publication Critical patent/DE69327312D1/de
Application granted granted Critical
Publication of DE69327312T2 publication Critical patent/DE69327312T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69327312T 1992-04-29 1993-04-28 Deazaaminopterine für behandlung von entzündungen Expired - Fee Related DE69327312T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87577992A 1992-04-29 1992-04-29
US891993A 1993-01-26 1993-01-26
PCT/US1993/003965 WO1993022312A1 (en) 1992-04-29 1993-04-28 Deazaaminopterins for treatment of inflammation

Publications (2)

Publication Number Publication Date
DE69327312D1 DE69327312D1 (de) 2000-01-20
DE69327312T2 true DE69327312T2 (de) 2000-07-13

Family

ID=26678795

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69327312T Expired - Fee Related DE69327312T2 (de) 1992-04-29 1993-04-28 Deazaaminopterine für behandlung von entzündungen

Country Status (6)

Country Link
EP (1) EP0638079B1 (de)
JP (1) JPH07506369A (de)
AU (1) AU4220193A (de)
CA (1) CA2133442A1 (de)
DE (1) DE69327312T2 (de)
WO (1) WO1993022312A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264437A (en) * 1992-03-20 1993-11-23 Syntex (U.S.A.) Inc. Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones
ATE312820T1 (de) * 1999-10-28 2005-12-15 Trine Pharmaceuticals Inc Pumpeninhibitoren zur freisetzung von medikamenten
US7056917B2 (en) 2001-04-26 2006-06-06 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
EP1594863A1 (de) * 2003-02-11 2005-11-16 Prosidion Limited Tricyclo-substituierte amid glucokinase-aktivatoren
US9901578B2 (en) 2007-08-17 2018-02-27 Allos Therapeutics, Inc. Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer
EP3725775A1 (de) 2009-02-17 2020-10-21 Syntrix Biosystems, Inc. Pyridin- und pyrimidincarboxamide als cxcr2-modulatoren
DK2575466T3 (en) * 2010-06-02 2015-07-20 Allos Therapeutics Inc Methods of treating methotrexate resistant disorders of 10-propargyl-10-deazaaminopterin
EP2608672B1 (de) 2010-08-23 2020-12-16 Syntrix Biosystems, Inc. Aminopyridin- und aminopyrimidincarboxamide als cxcr2-modulatoren
CN102898415A (zh) * 2012-10-31 2013-01-30 济南久创化学有限责任公司 雷替曲塞中间体n-（5-甲氨基-2-噻吩甲酰基）-l-谷氨酸二乙酯的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4725687A (en) * 1986-04-28 1988-02-16 Southern Research Institute 5-methyl-5-deaza analogues of methotrexate and N10 -ethylaminopterin
WO1990000172A1 (en) * 1988-07-01 1990-01-11 Sloan-Kettering Institute For Cancer Research 5-deaza-5,7-disubstituted-aminopterin analogues
US5077404A (en) * 1989-08-29 1991-12-31 Piper James R Cyclized 5,10-dideazaaminopterin compounds
US5286726A (en) * 1990-04-12 1994-02-15 The Regents Of The University Of Michigan Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases
US5066828A (en) * 1990-04-12 1991-11-19 Merrell Dow Pharmaceuticals Inc. Difluoroglutamic acid conjugates with folates and anti-folates for the treatment of neoplastic diseases

Also Published As

Publication number Publication date
CA2133442A1 (en) 1993-11-11
EP0638079B1 (de) 1999-12-15
DE69327312D1 (de) 2000-01-20
JPH07506369A (ja) 1995-07-13
AU4220193A (en) 1993-11-29
EP0638079A1 (de) 1995-02-15
WO1993022312A1 (en) 1993-11-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee