DE69315319D1 - Gallensäuren-Binde - Google Patents

Gallensäuren-Binde

Info

Publication number
DE69315319D1
DE69315319D1 DE69315319T DE69315319T DE69315319D1 DE 69315319 D1 DE69315319 D1 DE 69315319D1 DE 69315319 T DE69315319 T DE 69315319T DE 69315319 T DE69315319 T DE 69315319T DE 69315319 D1 DE69315319 D1 DE 69315319D1
Authority
DE
Germany
Prior art keywords
bile acid
sequestrant
polymeric matrix
bandage
acid bandage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69315319T
Other languages
English (en)
Other versions
DE69315319T2 (de
Inventor
Larry Wayne Steffier
Robert Lee Albright
Eric Clyde Peters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rohm and Haas Co
Original Assignee
Rohm and Haas Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rohm and Haas Co filed Critical Rohm and Haas Co
Application granted granted Critical
Publication of DE69315319D1 publication Critical patent/DE69315319D1/de
Publication of DE69315319T2 publication Critical patent/DE69315319T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/60—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide containing nitrogen in addition to the carbonamido nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
DE69315319T 1992-12-21 1993-12-14 Gallensäuren-Binde Expired - Lifetime DE69315319T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/994,026 US5451397A (en) 1992-12-21 1992-12-21 Bile acid sequestrant

Publications (2)

Publication Number Publication Date
DE69315319D1 true DE69315319D1 (de) 1998-01-02
DE69315319T2 DE69315319T2 (de) 1998-04-23

Family

ID=25540215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69315319T Expired - Lifetime DE69315319T2 (de) 1992-12-21 1993-12-14 Gallensäuren-Binde

Country Status (16)

Country Link
US (1) US5451397A (de)
EP (1) EP0606742B1 (de)
JP (1) JPH06192129A (de)
KR (1) KR940013515A (de)
CN (1) CN1103871A (de)
AT (1) ATE160364T1 (de)
AU (1) AU5219993A (de)
BR (1) BR9305160A (de)
CA (1) CA2111631A1 (de)
DE (1) DE69315319T2 (de)
DK (1) DK0606742T3 (de)
ES (1) ES2109445T3 (de)
FI (1) FI935496A (de)
HU (1) HUT65692A (de)
NO (1) NO934489L (de)
PH (1) PH30119A (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US6203785B1 (en) * 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US5925379A (en) * 1997-03-27 1999-07-20 Geltex Pharmaceuticals, Inc. Interpenetrating polymer networks for sequestration of bile acids
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
GB2329334A (en) * 1997-09-18 1999-03-24 Reckitt & Colmann Prod Ltd Cholesterol-lowering agents
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
GB2373438A (en) * 2001-02-10 2002-09-25 Reckitt & Colmann Prod Ltd Cholesterol lowering compositions
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2980657A (en) * 1954-07-06 1961-04-18 Rohm & Haas Quaternary ammonium compounds of polymers of acrylamido type and methods for making them
US2845408A (en) * 1954-08-04 1958-07-29 Rohm & Haas Linear polymeric amides and methods of making them
FR1224301A (fr) * 1958-02-27 1960-06-23 Ciba Geigy Procédé de polymérisation de composés oléfiniques basiques par polymérisation dans le 1,2-dichloréthane
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3383281A (en) * 1961-09-22 1968-05-14 Merck & Co Inc Method for binding bile acids in vivo
NL130759C (de) * 1965-10-07
US3627872A (en) * 1968-04-08 1971-12-14 Upjohn Co Oral treatment of hyper-cholesteremia in mammals and birds with ether-type anion exchangers of polysaccharides
US3943114A (en) * 1969-06-11 1976-03-09 The Lubrizol Corporation Polymers of N-aminoalkyl acrylamides
BE756035A (fr) * 1969-09-12 1971-03-11 Inveresk Res Int Polymeres pontes
NL7017227A (de) * 1969-12-27 1971-06-29
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
GB1348642A (en) * 1970-10-15 1974-03-20 Howard A N Hypocholesterolaemic compositions
US3769399A (en) * 1971-03-05 1973-10-30 L Hagerman Intestinal bile acid binding process and compositions
US4211765A (en) * 1971-10-12 1980-07-08 Monsanto Company Method for controlling obesity
US4057533A (en) * 1972-07-03 1977-11-08 Gaf Corporation Process for preparation of quaternized cationic vinyllactam-acrylamide copolymers
US3974272A (en) * 1972-09-01 1976-08-10 Merck & Co., Inc. Palatable cholestyramine coacervate compositions
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
CS171962B1 (de) * 1974-02-01 1976-11-29
US3962420A (en) * 1974-07-03 1976-06-08 Rohm And Haas Company Dissolution of gallstones
US4082564A (en) * 1975-09-09 1978-04-04 Rohm And Haas Company Sugar decolorizing quaternary ammonium acrylamide resins
FR2352547A1 (fr) * 1976-05-25 1977-12-23 Viridis Ets Nouvelle resine anionique a action hypocholesterolemiante, son procede de preparation et compositions therapeutiques la contenant
US4265879A (en) * 1977-09-13 1981-05-05 Monsanto Company Method for controlling blood triglycerides
IT1106718B (it) * 1978-12-21 1985-11-18 Alfa Farmaceutici Spa Composizioni a base di resine anioniche salificate farmacologicamente attive
DD148213A5 (de) * 1978-12-27 1981-05-13 Stockhausen & Cie Chem Fab Verfahren zur herstellung von alpha-beta-ungesaettigten n-substituierten carbonsaeureamiden
US4237218A (en) * 1979-02-09 1980-12-02 Bio-Rad Laboratories, Inc. Micro-carrier cell culture
US4393145A (en) * 1979-05-01 1983-07-12 Etablissement Texcontor Anionic ion exchange resins with cholesterol-decreasing properties
US4229267A (en) * 1979-06-01 1980-10-21 Richardson Chemical Company Alkaline bright zinc plating and additive therefor
US4343730A (en) * 1981-03-09 1982-08-10 Petrolite Corporation Water-in-oil emulsions of polymers of quaternary ammonium compounds of the acrylamido type
US4359540A (en) * 1981-05-29 1982-11-16 Texaco Inc. Method for making rim elastomers using a catalyst system which is a polymer containing tertiary amine moieties
US4382853A (en) * 1981-12-02 1983-05-10 Texaco Inc. Demulsification of bitumen emulsions using combinations of chemical agents
US4405015A (en) * 1981-12-02 1983-09-20 Texaco Inc. Demulsification of bitumen emulsions
US4387017A (en) * 1981-12-02 1983-06-07 Texaco Inc. Demulsification of bitumen emulsions using polymers of diquaternary ammonium monomers containing hydroxyl groups
CA1180827A (en) * 1982-03-23 1985-01-08 Michael Heskins Polymeric flocculants
US4495367A (en) * 1982-07-06 1985-01-22 Celanese Corporation High charge density, cationic methacrylamide based monomers and their _polymers
RO85505B1 (ro) * 1982-11-08 1984-11-30 Institutul De Chimie Macromoleculara "Petru Poni" Procedeu de preparare a unor schimbatori de anioni slab bazici
US4649048A (en) * 1984-05-11 1987-03-10 Bristol-Myers Company Novel bile sequestrant resin
GB8416453D0 (en) * 1984-06-28 1984-08-01 Allied Colloids Ltd Aqueous polymer dispersions
US4788267A (en) * 1985-08-09 1988-11-29 National Starch And Chemical Corporation Base-catalyzed, low temperature self-crosslinking polymers
IT1188184B (it) * 1985-08-14 1988-01-07 Texcontor Ets Sali ammonici quaternari di polisaccaridi ad attivita' ipocolesterolemizzante
US4728696A (en) * 1985-12-02 1988-03-01 The Dow Chemical Company Amphiphilic monomer and hydrophobe associative composition containing a polymer of a water-soluble monomer and said amphiphilic monomer
US4731419A (en) * 1986-02-24 1988-03-15 Nalco Chemical Company Alkoxylated/cationically modified amide-containing polymers
US4759923A (en) * 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
US5178854A (en) * 1988-03-24 1993-01-12 Taisho Pharmaceutical Co., Ltd. Cholesterol-lowering agents
JPH02225507A (ja) * 1989-02-27 1990-09-07 Mitsui Cyanamid Co 重合体エマルジョン
US5236701A (en) * 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
CA2040996A1 (en) * 1990-05-02 1991-11-03 Robert L. Albright Composition and method for controlling cholesterol
CA2042870C (en) * 1991-05-17 1996-11-26 Leon Edward St. Pierre Metal ion coordinated polyamine resins for the lowering of blood cholesterol
CA2056035A1 (en) * 1991-06-18 1992-12-19 Walton B. Caldwell Polyamides bearing functionalized side chains useful as water soluble hopolipidemic agents

Also Published As

Publication number Publication date
HU9303476D0 (en) 1994-04-28
HUT65692A (en) 1994-07-28
DE69315319T2 (de) 1998-04-23
CN1103871A (zh) 1995-06-21
AU5219993A (en) 1994-06-30
NO934489D0 (no) 1993-12-09
EP0606742B1 (de) 1997-11-19
JPH06192129A (ja) 1994-07-12
EP0606742A1 (de) 1994-07-20
PH30119A (en) 1996-12-27
FI935496A0 (fi) 1993-12-08
KR940013515A (ko) 1994-07-15
US5451397A (en) 1995-09-19
NO934489L (no) 1994-06-22
BR9305160A (pt) 1994-07-26
ES2109445T3 (es) 1998-01-16
ATE160364T1 (de) 1997-12-15
FI935496A (fi) 1994-06-22
DK0606742T3 (da) 1998-07-27
CA2111631A1 (en) 1994-06-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition