DE69314115D1 - Fluoreszierende pH-Indikatoren - Google Patents

Fluoreszierende pH-Indikatoren

Info

Publication number
DE69314115D1
DE69314115D1 DE69314115T DE69314115T DE69314115D1 DE 69314115 D1 DE69314115 D1 DE 69314115D1 DE 69314115 T DE69314115 T DE 69314115T DE 69314115 T DE69314115 T DE 69314115T DE 69314115 D1 DE69314115 D1 DE 69314115D1
Authority
DE
Germany
Prior art keywords
indicators
fluorescent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69314115T
Other languages
English (en)
Other versions
DE69314115T2 (de
Inventor
J Bruce Pitner
Randal A Hoke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Publication of DE69314115D1 publication Critical patent/DE69314115D1/de
Application granted granted Critical
Publication of DE69314115T2 publication Critical patent/DE69314115T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B11/00—Diaryl- or thriarylmethane dyes
    • C09B11/04—Diaryl- or thriarylmethane dyes derived from triarylmethanes, i.e. central C-atom is substituted by amino, cyano, alkyl
    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Luminescent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69314115T 1992-07-13 1993-07-09 Fluoreszierende pH-Indikatoren Expired - Fee Related DE69314115T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/912,426 US5302731A (en) 1992-07-13 1992-07-13 Fluorescent pH indicators

Publications (2)

Publication Number Publication Date
DE69314115D1 true DE69314115D1 (de) 1997-10-30
DE69314115T2 DE69314115T2 (de) 1998-01-15

Family

ID=25431898

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69314115T Expired - Fee Related DE69314115T2 (de) 1992-07-13 1993-07-09 Fluoreszierende pH-Indikatoren

Country Status (5)

Country Link
US (3) US5302731A (de)
EP (1) EP0582836B1 (de)
JP (1) JPH07122026B2 (de)
CA (1) CA2099922C (de)
DE (1) DE69314115T2 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69503897T2 (de) * 1994-03-25 1999-01-14 Novartis Ag Optischer sensor zur bestimmung von ionen
US5650512A (en) * 1995-06-07 1997-07-22 Systemix Fluorescent labeling reagents
US5798276A (en) 1995-06-07 1998-08-25 Molecular Probes, Inc. Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability
US5672515A (en) * 1995-09-12 1997-09-30 Optical Sensors Incorporated Simultaneous dual excitation/single emission fluorescent sensing method for PH and pCO2
US5846737A (en) * 1996-07-26 1998-12-08 Molecular Probes, Inc. Conjugates of sulforhodamine fluorophores with enhanced fluorescence
GB9716476D0 (en) * 1997-08-04 1997-10-08 Amersham Int Plc Dye intermediate and method
US6130101A (en) * 1997-09-23 2000-10-10 Molecular Probes, Inc. Sulfonated xanthene derivatives
US6376149B2 (en) 1999-05-26 2002-04-23 Yale University Methods and compositions for imaging acids in chemically amplified photoresists using pH-dependent fluorophores
US6114518A (en) * 1999-09-30 2000-09-05 Becton, Dickinson And Company Synthesis and use of labelled phosphoramidite compositions
DE60134219D1 (de) * 2000-02-28 2008-07-10 Daiichi Pure Chemicals Co Ltd Messverfahren basierend auf Fluoreszenz- Energie-Transfer mit einem Donor langer Fluoreszenzlebenszeit
AU2001253582B2 (en) 2000-04-17 2006-02-02 Yale University Method for measuring diffusion of photogenerated catalyst in chemically amplified resists
US20040054195A1 (en) * 2002-01-10 2004-03-18 Jianxin Gao Xanthene derivatives
CA2474458A1 (en) * 2002-01-31 2003-08-07 Mitchell C. Sanders Method for detecting microorganisms
EP1553408A4 (de) * 2002-07-08 2005-08-17 Tetsuo Nagano Fluoreszenzsonde
US7198756B2 (en) * 2002-07-11 2007-04-03 Optical Sensors Incorporated Non-invasive measurement of pH
US20060211122A1 (en) * 2002-10-16 2006-09-21 Tetsuo Nagano Reagents for the measurement of peroxynitrites
US7696245B2 (en) * 2003-03-28 2010-04-13 Sekisui Medical Co., Ltd. Fluorescent probe for zinc
EP1649275A4 (de) * 2003-08-01 2007-12-19 Glotell Products Inc Farbstofflösungen zur verwendung in verfahren zum nachweis der zuvor erfolgten evaporation von wasserfreiem ammoniak und der produktion illegaler drogen
JP4767863B2 (ja) * 2003-11-03 2011-09-07 エチコン・インコーポレーテツド 比色基質、比色センサー、および使用方法
JP2005194244A (ja) * 2004-01-09 2005-07-21 Shigenobu Yano 亜鉛イオン蛍光センサー
US8183052B2 (en) * 2004-08-19 2012-05-22 Blood Cell Storage, Inc. Methods and apparatus for sterility testing
US8097725B2 (en) * 2004-12-03 2012-01-17 Roche Diagnostics Operations, Inc. Luminescent indicator dye and optical sensor
FR2880619B1 (fr) * 2005-01-10 2010-03-12 Cebal Sas Emballages plastiques, en particulier tubes souples, contenant des substances reactives associees a un temoin de presence
EP1910555A2 (de) * 2005-07-13 2008-04-16 ECI Biotech Inc. Substrate, sensoren und verfahren zur beurteilung vonleiden in weiblichen individuen
EP2989975B1 (de) 2007-02-06 2018-06-13 Medtronic MiniMed, Inc. Optische systeme und verfahren zur ratiometrischen messung der blutzuckerkonzentration
CA2686065A1 (en) 2007-05-10 2008-11-20 Glumetrics, Inc. Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement
WO2009067626A1 (en) 2007-11-21 2009-05-28 Glumetrics, Inc. Use of an equilibrium intravascular sensor to achieve tight glycemic control
WO2009129186A2 (en) * 2008-04-17 2009-10-22 Glumetrics, Inc. Sensor for percutaneous intravascular deployment without an indwelling cannula
US20110077477A1 (en) 2009-09-30 2011-03-31 Glumetrics, Inc. Sensors with thromboresistant coating
US8467843B2 (en) * 2009-11-04 2013-06-18 Glumetrics, Inc. Optical sensor configuration for ratiometric correction of blood glucose measurement
EP2506005A1 (de) 2011-03-29 2012-10-03 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO pH-Sensor
US9040307B2 (en) 2011-05-27 2015-05-26 Blood Cell Storage, Inc. Fluorescent pH detector system and related methods
JP5948827B2 (ja) * 2011-12-02 2016-07-06 住友化学株式会社 化合物
JP5948826B2 (ja) * 2011-12-02 2016-07-06 住友化学株式会社 化合物
US9702824B2 (en) * 2012-03-09 2017-07-11 Promega Corporation pH sensors
US20150160246A1 (en) 2013-12-11 2015-06-11 Analiza, Inc. Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells
US9709556B2 (en) 2013-12-11 2017-07-18 Analiza, Inc. Devices and methods for determining and/or isolating circulating cancer cells
CN103992791B (zh) * 2014-06-06 2016-08-24 福建师范大学 一种在弱酸性范围有线性响应的罗丹明基pH值荧光探针及其制备方法
US11713376B2 (en) * 2017-09-12 2023-08-01 Eth Zurich Transmembrane pH-gradient polymersomes for the quantification of ammonia in body fluids
KR102205473B1 (ko) * 2018-12-21 2021-01-21 칸트사이언스 주식회사 세포 내 pH 측정방법
CN112853606A (zh) * 2020-11-11 2021-05-28 北京化工大学 一种酸性气体响应的高弹性可拉伸白色荧光纳米纤维膜的制备方法
CN115093846A (zh) * 2022-08-09 2022-09-23 杭州汇蓝气体设备有限公司 用于二氧化碳浓度检测的材料及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855225A (en) * 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4945171A (en) * 1987-08-10 1990-07-31 Molecular Probes, Inc. Xanthene dyes having a fused (C) benzo ring

Also Published As

Publication number Publication date
CA2099922A1 (en) 1994-01-14
JPH06207112A (ja) 1994-07-26
EP0582836A1 (de) 1994-02-16
JPH07122026B2 (ja) 1995-12-25
US5302731A (en) 1994-04-12
CA2099922C (en) 1997-04-15
DE69314115T2 (de) 1998-01-15
EP0582836B1 (de) 1997-09-24
US5393514A (en) 1995-02-28
US5380880A (en) 1995-01-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee