DE69311896D1 - Aminocyclohexylamide für antiarrhythmische und anästhetische verwendungen - Google Patents
Aminocyclohexylamide für antiarrhythmische und anästhetische verwendungenInfo
- Publication number
- DE69311896D1 DE69311896D1 DE69311896T DE69311896T DE69311896D1 DE 69311896 D1 DE69311896 D1 DE 69311896D1 DE 69311896 T DE69311896 T DE 69311896T DE 69311896 T DE69311896 T DE 69311896T DE 69311896 D1 DE69311896 D1 DE 69311896D1
- Authority
- DE
- Germany
- Prior art keywords
- aminocyclohexylamides
- antiarrhythmic
- cardiac
- pharmaceutical composition
- sodium channels
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85806092A | 1992-03-26 | 1992-03-26 | |
PCT/CA1993/000124 WO1993019056A1 (en) | 1992-03-26 | 1993-03-26 | Aminocyclohexylamides for antiarrhythmic and anaesthetic uses |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69311896D1 true DE69311896D1 (de) | 1997-08-07 |
DE69311896T2 DE69311896T2 (de) | 1997-10-16 |
Family
ID=25327386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69311896T Expired - Lifetime DE69311896T2 (de) | 1992-03-26 | 1993-03-26 | Aminocyclohexylamide für antiarrhythmische und anästhetische verwendungen |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0632806B1 (de) |
JP (1) | JP3190676B2 (de) |
AT (1) | ATE154934T1 (de) |
AU (1) | AU668932B2 (de) |
CA (1) | CA2132841C (de) |
DE (1) | DE69311896T2 (de) |
ES (1) | ES2104142T3 (de) |
HK (1) | HK1000684A1 (de) |
WO (1) | WO1993019056A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100631299B1 (ko) * | 1998-04-01 | 2006-10-09 | 카디오메 파마 코포레이션 | 아미노사이클로헥실 에테르 화합물 및 이를 포함하는 약제학적 조성물 |
WO2000051981A1 (en) * | 1999-03-04 | 2000-09-08 | Nortran Pharmaceuticals Inc. | Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics |
US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
DE10213051B4 (de) * | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
JP4919661B2 (ja) | 2003-05-02 | 2012-04-18 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物およびそれらの用途 |
US7345086B2 (en) | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
CN100441568C (zh) * | 2003-05-02 | 2008-12-10 | 卡迪欧梅制药公司 | 氨基环己基醚化合物和它们的用途 |
WO2005018635A2 (en) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
US7977373B2 (en) | 2004-04-01 | 2011-07-12 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
WO2005097087A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
EP1868598B1 (de) | 2004-11-08 | 2014-04-23 | Cardiome Pharma Corp. | Neuer dosierungsplan für ionenkanalmodulierende verbindungen zur behandlung von akutem vorhofflimmern bei menschen |
US9006460B2 (en) | 2010-08-16 | 2015-04-14 | Cardiome International Ag | Process for preparing aminocyclohexyl ether compounds |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4598087A (en) * | 1983-12-06 | 1986-07-01 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
JPS63500796A (ja) * | 1985-06-07 | 1988-03-24 | ジ・アップジョン・カンパニ− | アミノシクロアルキルアミドの抗不整脈剤用途 |
US4737493A (en) * | 1985-07-01 | 1988-04-12 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents |
US4663343A (en) * | 1985-07-19 | 1987-05-05 | Warner-Lambert Company | Substituted naphthalenyloxy-1,2-diaminocyclohexyl amide compounds |
US4855316A (en) * | 1988-02-18 | 1989-08-08 | Warner-Lambert Company | 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds |
AU626949B2 (en) * | 1988-12-06 | 1992-08-13 | Warner-Lambert Company | 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics |
US4906655A (en) * | 1989-01-24 | 1990-03-06 | Warner-Lambert Company | Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents |
-
1993
- 1993-03-26 AU AU38827/93A patent/AU668932B2/en not_active Ceased
- 1993-03-26 WO PCT/CA1993/000124 patent/WO1993019056A1/en active IP Right Grant
- 1993-03-26 ES ES93907699T patent/ES2104142T3/es not_active Expired - Lifetime
- 1993-03-26 CA CA002132841A patent/CA2132841C/en not_active Expired - Fee Related
- 1993-03-26 AT AT93907699T patent/ATE154934T1/de not_active IP Right Cessation
- 1993-03-26 DE DE69311896T patent/DE69311896T2/de not_active Expired - Lifetime
- 1993-03-26 EP EP93907699A patent/EP0632806B1/de not_active Expired - Lifetime
- 1993-03-26 JP JP51613593A patent/JP3190676B2/ja not_active Expired - Fee Related
-
1997
- 1997-11-26 HK HK97102242A patent/HK1000684A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2132841C (en) | 2001-03-20 |
ATE154934T1 (de) | 1997-07-15 |
EP0632806A1 (de) | 1995-01-11 |
JPH07505151A (ja) | 1995-06-08 |
DE69311896T2 (de) | 1997-10-16 |
JP3190676B2 (ja) | 2001-07-23 |
WO1993019056A1 (en) | 1993-09-30 |
HK1000684A1 (en) | 1998-04-17 |
EP0632806B1 (de) | 1997-07-02 |
AU3882793A (en) | 1993-10-21 |
ES2104142T3 (es) | 1997-10-01 |
AU668932B2 (en) | 1996-05-23 |
CA2132841A1 (en) | 1993-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |