DE69311873D1 - Fed-batch-Verfahren für Proteine sekretierende Zellen - Google Patents
Fed-batch-Verfahren für Proteine sekretierende ZellenInfo
- Publication number
- DE69311873D1 DE69311873D1 DE69311873T DE69311873T DE69311873D1 DE 69311873 D1 DE69311873 D1 DE 69311873D1 DE 69311873 T DE69311873 T DE 69311873T DE 69311873 T DE69311873 T DE 69311873T DE 69311873 D1 DE69311873 D1 DE 69311873D1
- Authority
- DE
- Germany
- Prior art keywords
- batch process
- secreting cells
- fed batch
- protein secreting
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11265392 | 1992-05-01 | ||
PCT/JP1993/000586 WO1993022448A1 (en) | 1992-05-01 | 1993-04-30 | Fed batch culture method for protein secreting cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69311873D1 true DE69311873D1 (de) | 1997-08-07 |
DE69311873T2 DE69311873T2 (de) | 1998-02-12 |
Family
ID=14592116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69311873T Expired - Fee Related DE69311873T2 (de) | 1992-05-01 | 1993-04-30 | Fed-batch-Verfahren für Proteine sekretierende Zellen |
Country Status (6)
Country | Link |
---|---|
US (1) | US5443968A (de) |
EP (1) | EP0592692B1 (de) |
JP (1) | JPH08508875A (de) |
CA (1) | CA2111561A1 (de) |
DE (1) | DE69311873T2 (de) |
WO (1) | WO1993022448A1 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995022599A1 (fr) * | 1994-02-18 | 1995-08-24 | Teijin Limited | Procede de mise en culture de cellules animales |
US6068995A (en) * | 1994-10-25 | 2000-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Method for producing protein |
AU4330597A (en) | 1996-08-30 | 1998-03-19 | Life Technologies, Inc. | Serum-free mammalian cell culture medium, and uses thereof |
US6692961B1 (en) | 1996-10-11 | 2004-02-17 | Invitrogen Corporation | Defined systems for epithelial cell culture and use thereof |
WO1998041611A1 (en) * | 1997-03-20 | 1998-09-24 | Regents Of The University Of Minnesota | Process for the continuous culture of cells |
BR0114374A (pt) * | 2000-10-02 | 2003-12-30 | Novo Nordisk As | Preparação compreendendo uma pluralidade de polipeptìdeos de fator vii, métodos para a determinação do padrão de glicoforma de fator vii e de polipeptìdeos relacionados com fator vii, e para a produção da dita preparação, formulação farmacêutica, métodos para o tratamento de uma sìndrome responsiva a fator vii, para a prevenção de sangramento indesejado, para a prevenção de coagulação sanguìnea indesejada, e para prevenção de reações mediadas por fator de tecido, e, uso da preparação |
DE10144906B4 (de) * | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
CN1309825C (zh) | 2001-10-02 | 2007-04-11 | 诺和诺德医疗保健公司 | 在真核细胞中生产重组蛋白的方法 |
CA2492267C (en) * | 2002-07-15 | 2013-09-10 | Immunex Corporation | Methods and media for controlling sialylation of proteins produced by mammalian cells |
DE10255508A1 (de) * | 2002-11-27 | 2004-06-17 | Forschungszentrum Jülich GmbH | Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen |
JP4740138B2 (ja) | 2003-10-10 | 2011-08-03 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 真核生物細胞におけるポリペプチドの大規模生産方法及びそれに適した培養容器 |
DK2493922T3 (en) | 2009-10-26 | 2017-04-24 | Hoffmann La Roche | Process for preparing a glycosylated immunoglobulin |
UY35343A (es) * | 2013-02-26 | 2014-09-30 | Bayer Healthcare Llc | Formulaciones y procedimientos para la producción de proteína recombinante aumentada |
BR112015032960B1 (pt) | 2013-07-04 | 2021-01-05 | F. Hoffmann-La Roche Ag | imunoensaio suprimido por interferência para detectar anticorpos anti-fármaco em amostras de soro |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6043386A (ja) * | 1983-08-20 | 1985-03-07 | Koken Kk | ヒト腎細胞癌由来樹立株細胞の増殖抑制剤の製造方法 |
CA1341228C (en) * | 1985-06-27 | 2001-05-15 | Mark J. Murray | Expression of protein c |
CA1340740C (en) * | 1987-12-08 | 1999-09-14 | Eileen R. Mulvihill | Co-expression in eukaryotic cells |
EP0343635B1 (de) * | 1988-05-25 | 1994-08-24 | Teijin Limited | Verfahren zur kontinuierlichen Züchtung von haftenden tierischen Zellen |
US5219752A (en) * | 1988-05-25 | 1993-06-15 | Teijin, Limited | Process for continuously culturing adherent animal cells |
US5328844A (en) * | 1990-05-09 | 1994-07-12 | University Of Colorado Foundation, Inc. | Culture media for mammalian cells |
-
1993
- 1993-04-30 DE DE69311873T patent/DE69311873T2/de not_active Expired - Fee Related
- 1993-04-30 EP EP93911965A patent/EP0592692B1/de not_active Expired - Lifetime
- 1993-04-30 US US08/170,361 patent/US5443968A/en not_active Expired - Fee Related
- 1993-04-30 CA CA002111561A patent/CA2111561A1/en not_active Abandoned
- 1993-04-30 JP JP5519133A patent/JPH08508875A/ja active Pending
- 1993-04-30 WO PCT/JP1993/000586 patent/WO1993022448A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CA2111561A1 (en) | 1993-11-11 |
EP0592692B1 (de) | 1997-07-02 |
US5443968A (en) | 1995-08-22 |
DE69311873T2 (de) | 1998-02-12 |
WO1993022448A1 (en) | 1993-11-11 |
JPH08508875A (ja) | 1996-09-24 |
EP0592692A1 (de) | 1994-04-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |