DE69308349D1 - Zeitliche Modulation eines Elektrosprays - Google Patents

Zeitliche Modulation eines Elektrosprays

Info

Publication number
DE69308349D1
DE69308349D1 DE69308349T DE69308349T DE69308349D1 DE 69308349 D1 DE69308349 D1 DE 69308349D1 DE 69308349 T DE69308349 T DE 69308349T DE 69308349 T DE69308349 T DE 69308349T DE 69308349 D1 DE69308349 D1 DE 69308349D1
Authority
DE
Germany
Prior art keywords
electrospray
temporal modulation
temporal
modulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69308349T
Other languages
English (en)
Other versions
DE69308349T2 (de
Inventor
Joseph A Jarrell
Michael J Tomany
Douglas Wittmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Waters Investments Ltd
Original Assignee
Waters Investments Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Waters Investments Ltd filed Critical Waters Investments Ltd
Application granted granted Critical
Publication of DE69308349D1 publication Critical patent/DE69308349D1/de
Publication of DE69308349T2 publication Critical patent/DE69308349T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G01N30/724—Nebulising, aerosol formation or ionisation
    • G01N30/7266—Nebulising, aerosol formation or ionisation by electric field, e.g. electrospray
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Electrostatic Spraying Apparatus (AREA)
DE69308349T 1992-04-10 1993-04-05 Zeitliche Modulation eines Elektrosprays Expired - Lifetime DE69308349T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/866,605 US5306910A (en) 1992-04-10 1992-04-10 Time modulated electrified spray apparatus and process

Publications (2)

Publication Number Publication Date
DE69308349D1 true DE69308349D1 (de) 1997-04-10
DE69308349T2 DE69308349T2 (de) 1997-07-31

Family

ID=25347977

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69308349T Expired - Lifetime DE69308349T2 (de) 1992-04-10 1993-04-05 Zeitliche Modulation eines Elektrosprays

Country Status (4)

Country Link
US (2) US5306910A (de)
EP (1) EP0565027B1 (de)
JP (2) JP3299335B2 (de)
DE (1) DE69308349T2 (de)

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US6396057B1 (en) * 2000-04-18 2002-05-28 Waters Investments Limited Electrospray and other LC/MS interfaces
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WO2003065405A1 (fr) 2002-01-31 2003-08-07 Hitachi High-Technologies Corporation Spectrometre de masse a ionisation par electrospray et procede associe
US6703610B2 (en) 2002-02-01 2004-03-09 Agilent Technologies, Inc. Skimmer for mass spectrometry
US6888132B1 (en) 2002-06-01 2005-05-03 Edward W Sheehan Remote reagent chemical ionization source
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US6677593B1 (en) * 2002-08-28 2004-01-13 Ut-Battelle, Llc Planar flow-by electrode capacitive electrospray ion source
US6949740B1 (en) 2002-09-13 2005-09-27 Edward William Sheehan Laminated lens for introducing gas-phase ions into the vacuum systems of mass spectrometers
SE0300454D0 (sv) * 2003-02-19 2003-02-19 Aamic Ab Nozzles for electrospray ionization and methods of fabricating them
US6791080B2 (en) * 2003-02-19 2004-09-14 Science & Engineering Services, Incorporated Method and apparatus for efficient transfer of ions into a mass spectrometer
DE602004019005D1 (de) 2003-04-17 2009-03-05 Kanzaki Kokyukoki Mfg Co Ltd Leistungsteilungs- und Wellenantriebseinrichtung für ein Arbeitsfahrzeug
US7007710B2 (en) * 2003-04-21 2006-03-07 Predicant Biosciences, Inc. Microfluidic devices and methods
US8097416B2 (en) 2003-09-11 2012-01-17 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US8288523B2 (en) 2003-09-11 2012-10-16 Ibis Biosciences, Inc. Compositions for use in identification of bacteria
US8546082B2 (en) * 2003-09-11 2013-10-01 Ibis Biosciences, Inc. Methods for identification of sepsis-causing bacteria
US7071465B2 (en) 2003-10-14 2006-07-04 Washington State University Research Foundation Ion mobility spectrometry method and apparatus
US7624403B2 (en) * 2004-03-25 2009-11-24 Microsoft Corporation API for building semantically rich diagramming tools
US20060022130A1 (en) * 2004-07-29 2006-02-02 Predicant Biosciences, Inc., A Delaware Corporation Microfluidic devices and methods with integrated electrical contact
US20060060769A1 (en) * 2004-09-21 2006-03-23 Predicant Biosciences, Inc. Electrospray apparatus with an integrated electrode
US7081621B1 (en) 2004-11-15 2006-07-25 Ross Clark Willoughby Laminated lens for focusing ions from atmospheric pressure
US7394065B2 (en) * 2005-03-28 2008-07-01 California Institute Of Technology Chemical probe using field-induced droplet ionization mass spectrometry
US7138626B1 (en) 2005-05-05 2006-11-21 Eai Corporation Method and device for non-contact sampling and detection
WO2006130475A2 (en) * 2005-05-27 2006-12-07 Ionwerks, Inc. Multi-beam ion mobility time-of-flight mass spectrometry with multi-channel data recording
US7568401B1 (en) 2005-06-20 2009-08-04 Science Applications International Corporation Sample tube holder
US7385189B2 (en) * 2005-06-29 2008-06-10 Agilent Technologies, Inc. Nanospray ionization device and method
US7576322B2 (en) * 2005-11-08 2009-08-18 Science Applications International Corporation Non-contact detector system with plasma ion source
CN101206207B (zh) * 2006-12-22 2012-04-11 中国科学院大连化学物理研究所 一种微液相分离系统与质谱联用的多通道电喷雾离子源
US7960711B1 (en) 2007-01-22 2011-06-14 Chem-Space Associates, Inc. Field-free electrospray nebulizer
US8123396B1 (en) 2007-05-16 2012-02-28 Science Applications International Corporation Method and means for precision mixing
EP2160235B1 (de) 2007-06-01 2016-11-30 Purdue Research Foundation Diskontinuierliche atmosphärendruckschnittstelle
US8334506B2 (en) 2007-12-10 2012-12-18 1St Detect Corporation End cap voltage control of ion traps
US8008617B1 (en) 2007-12-28 2011-08-30 Science Applications International Corporation Ion transfer device
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US8071957B1 (en) 2009-03-10 2011-12-06 Science Applications International Corporation Soft chemical ionization source
WO2012021185A2 (en) * 2010-04-27 2012-02-16 University Of Notre Dame Du Lac Methods and apparatus for mass spectrometry utilizing an ac electrospray device
EP2666182B1 (de) * 2011-01-20 2019-11-13 Purdue Research Foundation (Prf) Synchronisation einer ionenerzeugung mit zyklierung einer diskontinuierlichen atmosphärischen schnittstelle
GB201211048D0 (en) * 2012-06-22 2012-08-01 Micromass Ltd Methods and apparatus for controlling the supply of ions
US9048079B2 (en) * 2013-02-01 2015-06-02 The Rockefeller University Method and apparatus for improving ion transmission into a mass spectrometer
JP6231219B2 (ja) 2013-12-24 2017-11-15 ウオーターズ・テクノロジーズ・コーポレイシヨン 電気的に接地された電気スプレーための大気インターフェース
CN117352365B (zh) * 2023-12-04 2024-03-19 湖南豪思生物科技有限公司 电离电流控制装置及质谱仪

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Also Published As

Publication number Publication date
EP0565027B1 (de) 1997-03-05
JP3299335B2 (ja) 2002-07-08
DE69308349T2 (de) 1997-07-31
JPH0650940A (ja) 1994-02-25
JP3447727B2 (ja) 2003-09-16
US5436446A (en) 1995-07-25
US5306910A (en) 1994-04-26
JP2002303606A (ja) 2002-10-18
EP0565027A1 (de) 1993-10-13

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