DE69233093D1 - Substituierte phenserine und phenylcarbamate von (-)-eserolin, (-)-n1-noreserolin und (-)-n1-benzylnoresorolin als spezifische acetylcholinesterase-inhibitoren - Google Patents

Substituierte phenserine und phenylcarbamate von (-)-eserolin, (-)-n1-noreserolin und (-)-n1-benzylnoresorolin als spezifische acetylcholinesterase-inhibitoren

Info

Publication number
DE69233093D1
DE69233093D1 DE69233093T DE69233093T DE69233093D1 DE 69233093 D1 DE69233093 D1 DE 69233093D1 DE 69233093 T DE69233093 T DE 69233093T DE 69233093 T DE69233093 T DE 69233093T DE 69233093 D1 DE69233093 D1 DE 69233093D1
Authority
DE
Germany
Prior art keywords
noreserolin
benzylnoresorolin
eserolin
phenserine
phenylcarbamate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69233093T
Other languages
English (en)
Other versions
DE69233093T2 (de
Inventor
Arnold Brossi
Malgarzota Brzostowska
S Rapoport
Nigel Greig
Xiao-Shu He
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/765,746 external-priority patent/US5171750A/en
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE69233093D1 publication Critical patent/DE69233093D1/de
Publication of DE69233093T2 publication Critical patent/DE69233093T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69233093T 1991-09-26 1992-09-28 Substituierte phenserine und phenylcarbamate von (-)-eserolin, (-)-n1-noreserolin und (-)-n1-benzylnoresorolin als spezifische acetylcholinesterase-inhibitoren Expired - Fee Related DE69233093T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/765,746 US5171750A (en) 1991-09-26 1991-09-26 Substituted phenserines as specific inhibitors of acetylcholinesterase
US86132992A 1992-03-31 1992-03-31
PCT/US1992/008228 WO1993006105A1 (en) 1991-09-26 1992-09-28 Substituted phenserines and phenylcarbamates of (-)-eseroline, (-)-n1-noreseroline, and (-)-n1-benzylnoreseroline; as specific inhibitors of acetylcholinesterase

Publications (2)

Publication Number Publication Date
DE69233093D1 true DE69233093D1 (de) 2003-07-10
DE69233093T2 DE69233093T2 (de) 2003-12-18

Family

ID=27117645

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69233093T Expired - Fee Related DE69233093T2 (de) 1991-09-26 1992-09-28 Substituierte phenserine und phenylcarbamate von (-)-eserolin, (-)-n1-noreserolin und (-)-n1-benzylnoresorolin als spezifische acetylcholinesterase-inhibitoren

Country Status (10)

Country Link
US (1) US5998460A (de)
EP (1) EP0606366B1 (de)
JP (1) JP3708957B2 (de)
AT (1) ATE242244T1 (de)
AU (1) AU674130B2 (de)
CA (1) CA2119783C (de)
DE (1) DE69233093T2 (de)
DK (1) DK0606366T3 (de)
ES (1) ES2201050T3 (de)
WO (1) WO1993006105A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932780A (en) * 1994-02-28 1999-08-03 Yissum Research Development Company Of Hebrew University Of Jerusalem Transgenic non-human animal assay system for anti-cholinesterase substances
US5338739A (en) * 1994-03-10 1994-08-16 Hoechst-Roussel Pharmaceuticals Inc. (Pyrrolidinyl)phenyl carbamates, compositions and use
BR9806184A (pt) * 1997-07-09 2001-06-19 Axonyx Inibidores de butirilcolinesterase altamente seletivos para o tratamento e o diagnóstico da doença de alzheimer e demências
US6534541B1 (en) 1999-10-19 2003-03-18 Novartis Ag Treatment of ocular disorders
US6495700B1 (en) 2002-01-09 2002-12-17 Axonyx, Inc. Process for producing phenserine and its analog
DE10301851A1 (de) * 2003-01-17 2004-07-29 Lts Lohmann Therapie-Systeme Ag Verfahren zur medikamentösen Prophylaxe gegen Vergiftungen durch Cholinesterase-Hemmer, sowie hierfür geeignete Wirkstoffe und Arzneimittel
DK2210605T3 (en) * 2003-11-04 2017-05-22 Tcd Royalty Sub Llc Daily single dose doses of trospium.
JP2007519738A (ja) * 2004-01-30 2007-07-19 アクソニクス，インコーポレイテッド 糖尿病の合併症の治療方法
US20050182044A1 (en) * 2004-02-17 2005-08-18 Bruinsma Gosse B. Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
CA2508585A1 (en) * 2004-06-01 2005-12-01 Axonyx, Inc. Transdermal delivery system for treatment of cognitive disorders
EP1604686A1 (de) * 2004-06-08 2005-12-14 Axonyx, Inc. Verwendung von Phenserine und einem HMG CoA reduktase Hemmer zur Verzögerung der Alzheimer Krankheit
WO2006138385A2 (en) * 2005-06-14 2006-12-28 Cancog Technologies Inc.24 Use of phenserine and analogs to treat behavioral problems and improve trainability
SG178773A1 (en) * 2006-11-13 2012-03-29 Ateris Technologies Llc Pesticide biomarker
US20110166043A1 (en) * 2007-11-14 2011-07-07 Jon Owen Nagy Biomarker detection-2
US8772345B2 (en) 2011-08-03 2014-07-08 Southwest Research Institute Oximes for treatment of peripheral and central nervous system exposure to acetyl cholinesterase inhibitors
US8653108B1 (en) * 2011-08-03 2014-02-18 Southwest Research Institute Oximes for treatment of peripheral and central nervous system exposure to acetyl cholinesterase inhibitors
WO2014113495A1 (en) 2013-01-15 2014-07-24 The Trustees Of Columbia University In The City Of New York Activation or reactivation of ache
US9162983B2 (en) 2013-05-22 2015-10-20 Southwest Research Institute Reactivators of organophosphorous inhibited acetylcholinesterase
US10111860B1 (en) 2016-01-15 2018-10-30 Aristea Translational Medicine Corporation Compositions and methods for treating concussion
US10864192B2 (en) 2016-01-15 2020-12-15 Aristea Translational Medicine Corporation Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions
US20230113944A1 (en) * 2020-01-10 2023-04-13 The Regents Of The University Of California Compositions and methods for the treatment of neurodegenerative diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199076B (it) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche Derivati della fisostigmina con proprieta'di inibizione della aceticolinesterasi e relativo procedimento di produzione
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
US4900748A (en) * 1988-03-04 1990-02-13 The United States Of America As Represented By The Department Of Health And Human Services Carbamates related to (-)-physostigmine as cholinergic agents
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use

Also Published As

Publication number Publication date
DK0606366T3 (da) 2003-10-06
CA2119783C (en) 2006-02-07
CA2119783A1 (en) 1993-04-01
DE69233093T2 (de) 2003-12-18
ES2201050T3 (es) 2004-03-16
US5998460A (en) 1999-12-07
ATE242244T1 (de) 2003-06-15
WO1993006105A1 (en) 1993-04-01
EP0606366A1 (de) 1994-07-20
EP0606366B1 (de) 2003-06-04
JPH07503703A (ja) 1995-04-20
JP3708957B2 (ja) 2005-10-19
AU2754492A (en) 1993-04-27
AU674130B2 (en) 1996-12-12

Similar Documents

Publication Publication Date Title
DE69233093D1 (de) Substituierte phenserine und phenylcarbamate von (-)-eserolin, (-)-n1-noreserolin und (-)-n1-benzylnoresorolin als spezifische acetylcholinesterase-inhibitoren
DE69736441D1 (de) Pharmazeutische zusammensetzung zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
AP1697A (en) Azabicycloalkanes as CCR5 modulators.
HUP0000558A2 (hu) Aktív D-vitamin analógok alkalmazása prosztatabetegségek kezelésére szolgáló gyógyszerkészítmények előállítására
AP2001002187A0 (en) Piperidines as CCR5 modulators.
DK1346041T3 (da) Terapeutiske midler og fremgangsmåder til anvendelse deraf til behandling af en amyloidogen sygdom
ATE177949T1 (de) Kombinationstherapie zur prophylaxe und/oder behandlung benigner prostatahyperplasie
MY132529A (en) Paroxetine hydrochloride anhydrate
NO20101190L (no) Anvendelse av buprenorfin i fremstillingen av et medikament
DK0975595T3 (da) Kokainanaloger
UA19171A (uk) Спосіб одержаhhя фіhілалкіламіhів або їх фармакологічhо прийhятhих солей
DK1187617T3 (da) Fremgangsmåde til at vælge koncentrationen af et amfipatisk antihistaminlægemiddel ved at bestemme lægemidlets overfladeaktivitetsmåltal
DE69717148T2 (de) 3-pyridylenantiomere und ihre verwendung als analgetika
LV12291A (lv) Savienojums un farmaceitiskas kompozicijas ar triptazes aktivitates izmainam saistitu slimibu arstesanai
DK0837935T3 (da) Den 3'-ikke-translaterede region af det humane prohibitin-gen
NO993275D0 (no) FremgangsmÕte ved terapeutisk administrering av anti-CD40L-forbindelser
ATE220904T1 (de) 2-phenyl-3-azoylbenzothiophene zur erhöhung der thrombomodulin expression
CA2119782A1 (en) Carbamate analogs of thiaphysovenine, pharmaceutical compositions, and method for inhibiting cholinesterases
HK1029937A1 (en) Use of phanquinone for the treatment of alzheimer s disease.
NO20000519L (no) 2-acylaminopropanaminer som takykininreseptorantagonister
DK675389A (da) Terapeutiske praeparater til forebyggelse af fibrinaflejringer
HUP0100611A2 (hu) Triazin vegyületek, és ilyeneket tartalmazó gyógyszerkészítmények a központi idegrendszer elváltozásainak kezelésére
HUP0000110A2 (hu) Azaciklusos, azabiciklusos vagy tetrahidropiridinszármazékokat tartalmazó, fájdalom kezelésére alkalmas gyógyászati készítmények
LV11940A (lv) Melatonina pielietojums personu arstesanai kuras cies no zalu atkaribas
EP0758312A4 (de) Substituierte kondensierte und verbrückte bicyclische verbindungen als therapeutische mittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee