DE69232790T2 - WATER-INSOLUBLE DERIVATIVES OF POLYANIONIC POLYSACCHARIDES - Google Patents

WATER-INSOLUBLE DERIVATIVES OF POLYANIONIC POLYSACCHARIDES

Info

Publication number
DE69232790T2
DE69232790T2 DE69232790T DE69232790T DE69232790T2 DE 69232790 T2 DE69232790 T2 DE 69232790T2 DE 69232790 T DE69232790 T DE 69232790T DE 69232790 T DE69232790 T DE 69232790T DE 69232790 T2 DE69232790 T2 DE 69232790T2
Authority
DE
Germany
Prior art keywords
water
composition
polyanionic polysaccharides
insoluble derivatives
nucleophile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232790T
Other languages
German (de)
Other versions
DE69232790D1 (en
Inventor
Robert Miller
W Burns
Xuejian Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of DE69232790D1 publication Critical patent/DE69232790D1/en
Application granted granted Critical
Publication of DE69232790T2 publication Critical patent/DE69232790T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B33/00—Preparation of derivatives of amylose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B33/00—Preparation of derivatives of amylose
    • C08B33/04—Ethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/424—Anti-adhesion agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

A water insoluble biocompatible composition that is formed by a method which combines, in an aqueous mixture, a polyanionic polysaccharide and an activating agent, under conditions sufficient to form the composition; a nucleophile may also be added. Also, a water insoluble, biocompatible composition that is formed by a method which combines, in an aqueous mixture, a polyanionic polysaccharide and an activating agent under conditions sufficient to form the composition; a modifying compound and a nucleophile may also be added.
DE69232790T 1991-05-20 1992-05-19 WATER-INSOLUBLE DERIVATIVES OF POLYANIONIC POLYSACCHARIDES Expired - Lifetime DE69232790T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70325491A 1991-05-20 1991-05-20
US07/833,973 US6174999B1 (en) 1987-09-18 1992-02-11 Water insoluble derivatives of polyanionic polysaccharides
PCT/US1992/004212 WO1992020349A1 (en) 1991-05-20 1992-05-19 Water insoluble derivatives of polyanionic polysaccharides

Publications (2)

Publication Number Publication Date
DE69232790D1 DE69232790D1 (en) 2002-10-31
DE69232790T2 true DE69232790T2 (en) 2003-07-24

Family

ID=27107102

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232790T Expired - Lifetime DE69232790T2 (en) 1991-05-20 1992-05-19 WATER-INSOLUBLE DERIVATIVES OF POLYANIONIC POLYSACCHARIDES

Country Status (8)

Country Link
US (3) US6174999B1 (en)
EP (2) EP1229050A3 (en)
JP (1) JP3425147B2 (en)
AT (1) ATE224916T1 (en)
AU (2) AU670030B2 (en)
CA (1) CA2109502C (en)
DE (1) DE69232790T2 (en)
WO (1) WO1992020349A1 (en)

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
IT1264101B1 (en) * 1993-03-29 1996-09-10 Alfa Wassermann Spa PROCESS FOR THE SYNTHESIS OF SEMI-SYNTHETIC HEPARIN OR HEPARAN STRUCTURE GLYCOSAMINOGLICANS MODIFIED IN POSITION 2
JP3274550B2 (en) * 1993-08-03 2002-04-15 株式会社日本触媒 Manufacturing method of water absorbing material
IT1268955B1 (en) * 1994-03-11 1997-03-18 Fidia Advanced Biopolymers Srl ACTIVE ESTERS OF CARBOXYL POLYSACCHARIDES
ITPD940054A1 (en) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl SULPHATED POLYSACCHARIDES
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US6294202B1 (en) 1994-10-06 2001-09-25 Genzyme Corporation Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US7883693B2 (en) * 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
CA2239775C (en) * 1995-12-18 2008-07-15 Collagen Corporation Crosslinked polymer compositions and methods for their use
US6150472A (en) * 1995-12-22 2000-11-21 Holland Biomaterials Group B.V. Multi-functional site containing polymers, and applications thereof
EP0780419A1 (en) * 1995-12-22 1997-06-25 Holland Biomaterials Group B.V. Multi-functional site containing polymers, and applications thereof
EP0781566B1 (en) * 1995-12-26 2004-07-28 Toyo Boseki Kabushiki Kaisha Organic solvent-soluble mucopolysaccharide, antibacterial antithrombogenic composition and medical material
JP3738860B2 (en) * 1996-01-08 2006-01-25 東洋紡績株式会社 Antithrombotic and antibacterial compositions and medical materials
JP3722239B2 (en) * 1996-01-09 2005-11-30 東洋紡績株式会社 Antithrombotic and antibacterial compositions and medical materials
US5791352A (en) * 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6203536B1 (en) * 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
IT1294797B1 (en) * 1997-07-28 1999-04-15 Fidia Advanced Biopolymers Srl USE OF HYALURONIC ACID DERIVATIVES IN THE PREPARATION OF BIOMATERIALS WITH PHYSICAL AND BUFFERING HEMOSTATIC ACTIVITIES
FR2766716B1 (en) 1997-08-01 2000-02-18 Cogent Sarl COMPOSITE PROSTHESIS FOR PREVENTION OF POST-SURGICAL ADHESIONS AND PROCESS FOR OBTAINING SAME
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
ITPD980169A1 (en) * 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl AMIDES OF HYALURONIC ACID AND ITS DERIVATIVES AND PROCESS FOR THEIR PREPARATION.
IT1301994B1 (en) * 1998-08-05 2000-07-20 Jasper Ltd Liability Co HYALURONIC ACID DERIVATIVES.
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
EP1137373A4 (en) 1998-12-04 2004-05-19 Chandrashekhar P Pathak Biocompatible crosslinked polymers
WO2000054762A2 (en) * 1999-03-15 2000-09-21 Trustees Of Boston University Use of cross linked polysaccharides for the inhibition of angiogenesis
US6309999B1 (en) * 1999-03-19 2001-10-30 Chandra P. Sharma Process for the preparation of an immunoadsorbent matrix
US7083777B1 (en) 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
CA2366897C (en) * 1999-04-06 2009-11-17 Andrew B. Onderdonk Immunomodulatory compositions and methods of use thereof
EP1228771A4 (en) * 1999-11-09 2003-01-29 Denki Kagaku Kogyo Kk Use of soluble cellulose derivative having been made hardly soluble in water and process for producing the same
CA2397578A1 (en) 1999-12-21 2001-06-28 Ajinomoto Co., Inc. A partial ester of a nitrogenous carboxylic acid with cellulose and a process for preparing the same
IT1317091B1 (en) * 2000-02-08 2003-05-26 S F I R Societa Fondaria Ind R CROSS-LINKED HYALURONIC ACID GEL WITH B-FUNCTIONAL L-AMINO ACIDS.
US6521223B1 (en) * 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
US6749865B2 (en) * 2000-02-15 2004-06-15 Genzyme Corporation Modification of biopolymers for improved drug delivery
CA2409431A1 (en) * 2000-06-09 2001-12-20 Genzyme Corporation Low molecular weight polymeric compositions
KR100375299B1 (en) * 2000-10-10 2003-03-10 주식회사 엘지생명과학 Crosslinked derivatives of hyaluronic acid by amide formation and their preparation methods
SV2003000753A (en) 2000-12-05 2003-06-16 Brigham & Womens Hospital USE OF ZWITTERIONIC POLYSACARIDS FOR THE SPECIFIC MODULATION OF IMMUNE PROGRESS
CA2437417C (en) * 2001-02-22 2016-07-26 Anika Therapeutics, Inc. Thiol-modified hyaluronan
US6508958B1 (en) 2001-07-16 2003-01-21 Gerald Wojcik Composition and process for inhibiting corrosion of metallic substrates
US6706214B2 (en) 2001-07-16 2004-03-16 Gerald Wojcik Composition and process for inhibiting corrosion of metallic substrates
US6500947B1 (en) * 2001-08-24 2002-12-31 Weyerhaeuser Company Superabsorbent polymer
US7687582B1 (en) * 2001-08-31 2010-03-30 Tda Research, Inc. Methods of production, purification, and processing of poly(heteroaromatic) block copolymers with improved solubility or dispersability
TWI245634B (en) * 2001-12-28 2005-12-21 Ind Tech Res Inst Preparation of a biodegradable thermal-sensitive gel system
AU2002367394A1 (en) * 2001-12-28 2003-07-24 Genzyme Corporation Bioresorbable foam packing device and use thereof
US6923961B2 (en) 2002-04-30 2005-08-02 Fziomed, Inc. Chemically activated carboxypolysaccharides and methods for use to inhibit adhesion formation and promote hemostasis
EP1539193A4 (en) * 2002-07-03 2010-05-05 Pericor Science Inc Compositions of hyaluronic acid and methods of use
US20030034136A1 (en) * 2002-07-19 2003-02-20 Neogi Amar N. Superabsorbent cellulosic fiber
US20030024663A1 (en) * 2002-07-19 2003-02-06 Neogi Amar N. Superabsorbent cellulosic fiber
US20030034137A1 (en) * 2002-07-19 2003-02-20 Neogi Amar N. Superabsorbent cellulosic fiber
US20030035950A1 (en) * 2002-07-19 2003-02-20 Neogi Amar N. Superabsorbent cellulosic fiber
US7338433B2 (en) 2002-08-13 2008-03-04 Allergan, Inc. Remotely adjustable gastric banding method
TWI251596B (en) * 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
WO2004063181A1 (en) 2003-01-03 2004-07-29 Genzyme Corporation Urea derivatives and their use as anti-inflammatory agents
FR2850282B1 (en) 2003-01-27 2007-04-06 Jerome Asius INJECTABLE IMPLANT BASED ON CERAMIC FOR THE FILLING OF WRINKLES, CUTANEOUS DEPRESSIONS AND SCARS, AND ITS PREPARATION
WO2004067575A1 (en) * 2003-01-31 2004-08-12 Biosphere S.P.A. Water soluble and biocompatible gels of hyaluronic acid cross-linked with bi-functional l-aminoacids or l-aminoesters
EP1638581A2 (en) 2003-03-31 2006-03-29 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
FR2861734B1 (en) 2003-04-10 2006-04-14 Corneal Ind CROSSLINKING OF LOW AND HIGH MOLECULAR MASS POLYSACCHARIDES; PREPARATION OF INJECTABLE SINGLE PHASE HYDROGELS; POLYSACCHARIDES AND HYDROGELS OBTAINED
PL1654002T5 (en) 2003-08-07 2014-06-30 Allergan Inc Compositions for delivery of therapeutics into the eyes
US9066912B2 (en) * 2003-11-17 2015-06-30 Ethicon, Inc. Drug-enhanced adhesion prevention
US8124120B2 (en) * 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
GB0329907D0 (en) * 2003-12-23 2004-01-28 Innomed Ltd Compositions
KR101291439B1 (en) 2004-01-23 2013-07-31 알러간, 인코포레이티드 Releasably-securale one-piece adjustable gastric band
FR2865737B1 (en) * 2004-02-03 2006-03-31 Anteis Sa BIOCOMPATIBLE RETICLE GEL
US8277831B2 (en) * 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention
CA2559520A1 (en) * 2004-03-17 2005-09-29 Genzyme Corporation Anti-adhesion spraying
KR101148445B1 (en) * 2004-04-28 2012-07-05 안지오디바이스 인터내셔널 게엠베하 Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
GB0411583D0 (en) * 2004-05-24 2004-06-23 Univ Bath Process
US20050281855A1 (en) * 2004-06-18 2005-12-22 National Defense Medical Center Process for preparing a cross-linked carboxyl polysaccharide and the cross-linked carboxyl polysaccharide
FR2873379B1 (en) * 2004-07-23 2008-05-16 Jerome Asius PROCESS FOR THE PREPARATION OF RETICULATED HYALURONIC ACID, RETICULATED HYALURONIC ACID WHICH CAN BE OBTAINED BY THIS METHOD, IMPLANT CONTAINING THE RETICULATED HYALURONIC ACID, AND USE THEREOF
TW200612991A (en) * 2004-09-07 2006-05-01 Chugai Pharmaceutical Co Ltd Process for producing water-soluble hyaluronic acid modification
US8303973B2 (en) 2004-09-17 2012-11-06 Angiotech Pharmaceuticals (Us), Inc. Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
CN1325125C (en) * 2004-12-23 2007-07-11 中国人民解放军第二军医大学 Anti blocking biomembrane
US20060142476A1 (en) * 2004-12-29 2006-06-29 Weerawarna S A Crosslinked carboxylated polymer
ITTO20040918A1 (en) * 2004-12-29 2005-03-29 Luigi Ambrosio POLYMERIC HYDROGEL BIODEGRADABLE ABSORBERS AND PROCEDURE FOR THEIR PREPARATION
ITPD20050056A1 (en) 2005-03-02 2006-09-03 Fidia Farmaceutici AMIDID DERIVATIVES OF HYALURONIC ACID IN OSTEOARTROSI
TW200643033A (en) * 2005-03-08 2006-12-16 Chugai Pharmaceutical Co Ltd Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue
EP1911769B1 (en) 2005-08-04 2013-10-30 Teijin Limited Cellulose derivative
US8043206B2 (en) 2006-01-04 2011-10-25 Allergan, Inc. Self-regulating gastric band with pressure data processing
FR2895907B1 (en) * 2006-01-06 2012-06-01 Anteis Sa VISCOELASTIC GEL FOR DERMATOLOGICAL USE
WO2007092451A2 (en) 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
CA2648395A1 (en) * 2006-04-07 2007-10-18 Adocia Bifunctionalized polysaccharides
CA2659612A1 (en) 2006-08-02 2008-02-07 Khorionyx Implantable preparation, useful more particularly for tissue complement and cicatrisation
FR2908415B1 (en) * 2006-11-10 2009-01-23 Abr Dev Sarl RETICULATED HYALURONIC ACID AND PROCESS FOR PREPARING THE SAME
WO2008081463A2 (en) * 2007-01-04 2008-07-10 Hepacore Ltd. Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
US8455001B2 (en) 2007-02-06 2013-06-04 Teijin Limited Cellulose derivative and method for production thereof
KR20080093877A (en) * 2007-04-17 2008-10-22 미쓰미덴기가부시기가이샤 Driving device
US7956513B2 (en) * 2007-04-20 2011-06-07 Mitsumi Electric Co., Ltd. Method of driving a driving device
BRPI0819075A2 (en) 2007-11-16 2014-10-07 Vicept Therapeutics Inc METHOD FOR TREATING PURPOSE IN AN INDIVIDUAL AND METHOD FOR REDUCING PURPOSE IN AN INDIVIDUAL BEFORE SURGICAL PROCEDURE
US9345809B2 (en) * 2007-11-28 2016-05-24 Fziomed, Inc. Carboxymethylcellulose polyethylene glycol compositions for medical uses
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
CN101903407B (en) 2007-12-17 2012-07-11 帝人株式会社 Cellulose derivative and hydrogel thereof
WO2009108760A2 (en) 2008-02-26 2009-09-03 Board Of Regents, The University Of Texas System Dendritic macroporous hydrogels prepared by crystal templating
US7842714B2 (en) 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
US9192571B2 (en) 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
WO2009148985A2 (en) * 2008-06-03 2009-12-10 E. I. Du Pont De Nemours And Company A tissue coating for preventing undesired tissue-to-tissue adhesions
US9242026B2 (en) 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
US8450475B2 (en) 2008-08-04 2013-05-28 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
CA2731791A1 (en) * 2008-08-05 2010-02-11 Teijin Limited Hydrogel
EP3184552B1 (en) 2008-09-02 2020-08-12 Tautona Group LP Threads of hyaluronic acid, methods of making thereof and uses thereof
US20100185049A1 (en) 2008-10-22 2010-07-22 Allergan, Inc. Dome and screw valves for remotely adjustable gastric banding systems
EP2408861A4 (en) * 2009-03-20 2013-05-29 Fpinnovations Cellulose materials with novel properties
US8748409B2 (en) * 2009-04-17 2014-06-10 Teijin Limited Polysaccharide derivative and hydrogel thereof
DE102009028526A1 (en) * 2009-08-13 2011-02-24 Leibniz-Institut Für Polymerforschung Dresden E.V. Process for the modification and functionalization of saccharides
FR2949688B1 (en) 2009-09-04 2012-08-24 Sofradim Production FABRIC WITH PICOTS COATED WITH A BIORESORBABLE MICROPOROUS LAYER
JP5686297B2 (en) 2009-12-28 2015-03-18 川澄化学工業株式会社 Anti-adhesive material
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US8840541B2 (en) 2010-02-25 2014-09-23 Apollo Endosurgery, Inc. Pressure sensing gastric banding system
NZ602405A (en) 2010-03-12 2014-12-24 Allergan Ind Sas A fluid composition comprising a hyaluronan polymer and mannitol for improving skin conditions
AU2011229730B2 (en) 2010-03-22 2016-01-07 Allergan, Inc. Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation
US9044298B2 (en) 2010-04-29 2015-06-02 Apollo Endosurgery, Inc. Self-adjusting gastric band
US9028394B2 (en) 2010-04-29 2015-05-12 Apollo Endosurgery, Inc. Self-adjusting mechanical gastric band
US20110270024A1 (en) 2010-04-29 2011-11-03 Allergan, Inc. Self-adjusting gastric band having various compliant components
US20110270025A1 (en) 2010-04-30 2011-11-03 Allergan, Inc. Remotely powered remotely adjustable gastric band system
WO2011148116A2 (en) * 2010-05-27 2011-12-01 Laboratoire Idenov Modified hyaluronic acid, method for manufacturing same and uses thereof
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US20120059216A1 (en) 2010-09-07 2012-03-08 Allergan, Inc. Remotely adjustable gastric banding system
JP6042815B2 (en) 2010-10-08 2016-12-14 ザ ボード オブ リージェンツ オブ ザ ユニバーシティ オブ テキサス システム Anti-adhesion barrier membranes using alginate and hyaluronic acid for biomedical applications
US8946194B2 (en) 2010-10-08 2015-02-03 Board Of Regents, University Of Texas System One-step processing of hydrogels for mechanically robust and chemically desired features
US8961393B2 (en) 2010-11-15 2015-02-24 Apollo Endosurgery, Inc. Gastric band devices and drive systems
DK2682409T3 (en) 2011-03-03 2017-09-11 Chugai Pharmaceutical Co Ltd Hyaluronic acid derivative modified with aminocarboxylic acid
FR2972626B1 (en) 2011-03-16 2014-04-11 Sofradim Production PROSTHETIC COMPRISING A THREE-DIMENSIONAL KNIT AND ADJUSTED
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
EP3536307B1 (en) 2011-06-03 2021-10-20 ALLERGAN Industrie, SAS Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
JP6273200B2 (en) 2011-07-12 2018-01-31 ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド Lipid-containing PSA compositions, methods of isolation and methods of use
FR2977790B1 (en) 2011-07-13 2013-07-19 Sofradim Production PROSTHETIC FOR UMBILIC HERNIA
FR2977789B1 (en) 2011-07-13 2013-07-19 Sofradim Production PROSTHETIC FOR UMBILIC HERNIA
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
RU2626513C2 (en) * 2011-09-14 2017-07-28 Аллерган, Инк. Dermal filler composition for small wrinkles treating
EP2760494B1 (en) 2011-09-30 2017-04-19 Sofradim Production Reversible stiffening of light weight mesh
KR101428145B1 (en) * 2011-11-24 2014-08-08 (주)아모레퍼시픽 Water-insoluble gel composition and manufacturing method of the same
US8876694B2 (en) 2011-12-07 2014-11-04 Apollo Endosurgery, Inc. Tube connector with a guiding tip
ES2824232T3 (en) * 2011-12-08 2021-05-11 Allergan Ind Sas Dermal filler compositions
US8961394B2 (en) 2011-12-20 2015-02-24 Apollo Endosurgery, Inc. Self-sealing fluid joint for use with a gastric band
FR2985170B1 (en) 2011-12-29 2014-01-24 Sofradim Production PROSTHESIS FOR INGUINAL HERNIA
FR2985271B1 (en) 2011-12-29 2014-01-24 Sofradim Production KNITTED PICOTS
WO2013146381A1 (en) * 2012-03-27 2013-10-03 テルモ株式会社 Drug coat layer and medical instrument including same
EP2801379B1 (en) * 2012-03-27 2017-03-08 Terumo Kabushiki Kaisha Coating composition and medical device
FR2988585B1 (en) 2012-03-28 2015-04-03 Cousin Biotech VISCERAL PLAQUE FOR COELIOSCOPY
FR2994185B1 (en) 2012-08-02 2015-07-31 Sofradim Production PROCESS FOR THE PREPARATION OF A POROUS CHITOSAN LAYER
JP6275044B2 (en) 2012-09-05 2018-02-07 中外製薬株式会社 Hyaluronic acid derivatives with amino acid and steryl groups introduced
FR2995779B1 (en) 2012-09-25 2015-09-25 Sofradim Production PROSTHETIC COMPRISING A TREILLIS AND A MEANS OF CONSOLIDATION
FR2995778B1 (en) 2012-09-25 2015-06-26 Sofradim Production ABDOMINAL WALL REINFORCING PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME
FR2995788B1 (en) 2012-09-25 2014-09-26 Sofradim Production HEMOSTATIC PATCH AND PREPARATION METHOD
AU2013322268B2 (en) 2012-09-28 2017-08-31 Sofradim Production Packaging for a hernia repair device
CN104981259B (en) 2012-12-11 2017-03-08 得克萨斯系统大学评议会 Kit comprising the aquagel membrane for preventing adhesion
US11565027B2 (en) 2012-12-11 2023-01-31 Board Of Regents, The University Of Texas System Hydrogel membrane for adhesion prevention
TWI478943B (en) * 2012-12-27 2015-04-01 Ind Tech Res Inst Use of polymer composition for the manufacture of a medical device or an inhibitor for inhibiting matrix metalloproteinases activity
CN103893813B (en) * 2012-12-28 2018-04-17 财团法人工业技术研究院 Polymeric composition and high molecular material
US20140315828A1 (en) 2013-04-22 2014-10-23 Allergan, Inc. Cross-linked silk-hyaluronic acid compositions
FR3006578B1 (en) 2013-06-07 2015-05-29 Sofradim Production PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY
FR3006581B1 (en) 2013-06-07 2016-07-22 Sofradim Production PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY
EP3000433B1 (en) 2014-09-29 2022-09-21 Sofradim Production Device for introducing a prosthesis for hernia treatment into an incision and flexible textile based prosthesis
EP3000432B1 (en) 2014-09-29 2022-05-04 Sofradim Production Textile-based prosthesis for treatment of inguinal hernia
EP3200838B1 (en) 2014-09-30 2019-09-18 Allergan Industrie, SAS Stable hydrogel compositions including additives
EP3029189B1 (en) 2014-12-05 2021-08-11 Sofradim Production Prosthetic porous knit, method of making same and hernia prosthesis
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
EP3059255B1 (en) 2015-02-17 2020-05-13 Sofradim Production Method for preparing a chitosan-based matrix comprising a fiber reinforcement member
EP3085337B1 (en) 2015-04-24 2022-09-14 Sofradim Production Prosthesis for supporting a breast structure
ES2676072T3 (en) 2015-06-19 2018-07-16 Sofradim Production Synthetic prosthesis comprising a knitted fabric and a non-porous film and method of forming it
EP3337321A4 (en) 2015-08-19 2019-07-17 President and Fellows of Harvard College Lipidated psa compositions and methods
JP6853785B2 (en) * 2015-11-12 2021-03-31 テルモ株式会社 Sustained-release topical agent
EP3195830B1 (en) 2016-01-25 2020-11-18 Sofradim Production Prosthesis for hernia repair
WO2018014012A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use
WO2018039496A1 (en) 2016-08-24 2018-03-01 Allergan, Inc. Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation
EP3312325B1 (en) 2016-10-21 2021-09-22 Sofradim Production Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained
WO2018165327A1 (en) 2017-03-08 2018-09-13 Alafair Biosciences, Inc. Hydrogel medium for the storage and preservation of tissue
EP3398554A1 (en) 2017-05-02 2018-11-07 Sofradim Production Prosthesis for inguinal hernia repair
CN107185028A (en) * 2017-05-05 2017-09-22 惠州华阳医疗器械有限公司 Hemostatic anti-adhesion material and preparation method and application thereof
US11732093B2 (en) 2017-07-26 2023-08-22 Polypeptide Therapeutic Solutions S.L. Cross polymers composed of polysaccharides and polyamino acids, and uses thereof
CN112334165A (en) 2018-06-15 2021-02-05 克罗马药品有限责任公司 Stabilized hyaluronic acid
US20210261760A1 (en) 2018-06-15 2021-08-26 Croma-Pharma Gmbh Hydrogel composition comprising a crosslinked polymer
EP3653171A1 (en) 2018-11-16 2020-05-20 Sofradim Production Implants suitable for soft tissue repair
WO2021123247A1 (en) 2019-12-19 2021-06-24 Croma-Pharma Gmbh Thiol-modified hyaluronan and hydrogel comprising the crosslinked hyaluronan
WO2023030435A1 (en) 2021-09-01 2023-03-09 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998974A (en) 1972-10-25 1976-12-21 Dynapol Corporation Comestibles containing non-nutritive flavoring
JPS568645B2 (en) * 1974-09-05 1981-02-25
DE2535518A1 (en) * 1975-08-08 1977-02-24 Henkel & Cie Gmbh LOW FOAM DETERGENT
US4308416A (en) * 1979-07-11 1981-12-29 Nl Industries, Inc. Water-tight electric cable
JPS5651995A (en) * 1979-10-05 1981-05-09 Green Cross Corp:The Preparation of interferon
US4526714A (en) 1982-12-13 1985-07-02 Cordis Europa N.V. Conjugates of anticoagulant and protein
SE8200751L (en) 1982-02-09 1983-08-10 Olle Larm PROCEDURE FOR COVALENT COUPLING FOR MANUFACTURE OF CONJUGATE AND REQUIRED PRODUCTS
US4973493A (en) * 1982-09-29 1990-11-27 Bio-Metric Systems, Inc. Method of improving the biocompatibility of solid surfaces
CA1238043A (en) 1983-12-15 1988-06-14 Endre A. Balazs Water insoluble preparations of hyaluronic acid and processes therefor
IL74715A0 (en) 1984-03-27 1985-06-30 Univ New Jersey Med Biodegradable matrix and methods for producing same
SE442820B (en) 1984-06-08 1986-02-03 Pharmacia Ab GEL OF THE CROSS-BOND HYALURONIC ACID FOR USE AS A GLASS BODY SUBSTITUTE
SE456346B (en) 1984-07-23 1988-09-26 Pharmacia Ab GEL TO PREVENT ADHESION BETWEEN BODY TISSUE AND SET FOR ITS PREPARATION
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4582865A (en) 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4780414A (en) * 1985-01-18 1988-10-25 Bio-Technology General Corp. Method of producing high molecular weight sodium hyallronate by fermentation of streptococcus
SE8501022L (en) 1985-03-01 1986-09-02 Pharmacia Ab FORMAT CREATES AND PROCEDURES FOR ITS PREPARATION
US4713448A (en) 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4774093A (en) 1985-06-25 1988-09-27 Fmc Corporation Polysaccharide compositions, preparation and uses
US4734285A (en) * 1985-10-28 1988-03-29 The Dow Chemical Company Sustained release compositions
DE3542002A1 (en) 1985-11-28 1987-06-04 Bayer Ag 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7- (1-PIPERAZINYL) -3-QUINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR ANTIBACTERIAL AGENTS CONTAINING THEM
EP0224987B1 (en) 1985-11-29 1992-04-15 Biomatrix, Inc. Drug delivery systems based on hyaluronan, derivatives thereof and their salts and method of producing same
EP0244178A3 (en) 1986-04-28 1989-02-08 Iolab, Inc Intraocular dosage compositions and method of use
US4795741A (en) 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
US4937270A (en) * 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US6030958A (en) 1987-09-18 2000-02-29 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US6174999B1 (en) * 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5017229A (en) * 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
US5527893A (en) * 1987-09-18 1996-06-18 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US4810748A (en) * 1988-04-15 1989-03-07 Dow Corning Corporation Concrete joint sealant having improved adhesion
IT1219587B (en) * 1988-05-13 1990-05-18 Fidia Farmaceutici SELF-CROSS-LINKED CARBOXYLY POLYSACCHARIDES
EP0416250A3 (en) * 1989-08-01 1991-08-28 The Research Foundation Of State University Of New York N-acylurea and o-acylisourea derivatives of hyaluronic acid
US5356883A (en) * 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
WO1991004276A1 (en) * 1989-09-25 1991-04-04 Asahi Kasei Kogyo Kabushiki Kaisha Isolated, physiologically active human thrombomodulin polypeptide
JP3162069B2 (en) * 1990-09-21 2001-04-25 生化学工業株式会社 Peptide derivative and therapeutic agent for thrombosis
IT1260154B (en) 1992-07-03 1996-03-28 Lanfranco Callegaro HYALURONIC ACID AND ITS DERIVATIVES IN INTERPENETRATING POLYMERS (IPN)
JP2995090B2 (en) 1993-03-19 1999-12-27 キユー・メド・アクチエボラーグ Compositions and methods for tissue augmentation
DE4435548A1 (en) * 1994-10-05 1996-04-11 Rhein Chemie Rheinau Gmbh Stabilized lubricant base substance
US6294202B1 (en) 1994-10-06 2001-09-25 Genzyme Corporation Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers

Also Published As

Publication number Publication date
JPH06508169A (en) 1994-09-14
EP0587715B1 (en) 2002-09-25
ATE224916T1 (en) 2002-10-15
DE69232790D1 (en) 2002-10-31
EP0587715A1 (en) 1994-03-23
CA2109502A1 (en) 1992-11-21
EP0587715A4 (en) 1995-08-09
EP1229050A2 (en) 2002-08-07
US6174999B1 (en) 2001-01-16
US5760200A (en) 1998-06-02
AU670030B2 (en) 1996-07-04
US6943154B2 (en) 2005-09-13
JP3425147B2 (en) 2003-07-07
CA2109502C (en) 2003-07-29
WO1992020349A1 (en) 1992-11-26
EP1229050A3 (en) 2003-05-07
US20010039336A1 (en) 2001-11-08
AU5226796A (en) 1996-08-01
AU2143492A (en) 1992-12-30

Similar Documents

Publication Publication Date Title
DE69232790T2 (en) WATER-INSOLUBLE DERIVATIVES OF POLYANIONIC POLYSACCHARIDES
DK0537292T3 (en) Water-insoluble derivatives of hyaloronic acid
BR8700386A (en) PSEUDOPLASTIC ACID COMPOSITES
MXPA01008283A (en) Polysaccharide compositions and uses thereof.
ATE139666T1 (en) AGRICULTURAL FOAM COMPOSITIONS
GB1404507A (en) Polysaccharide compositions
NO842665L (en) BIOPOLYMERS AND PROCEDURES FOR THEIR PREPARATION
AU613769B2 (en) Shampoo composition
DE69000719D1 (en) SKIN CLEANSER.
TW277050B (en)
ES541054A0 (en) A PROCEDURE FOR PREPARING A PHARMACEUTICAL COMPOSITION INCLUDING AZAPROPANONE
DE69016087D1 (en) Stable solutions of Rebeccamycin derivatives and their production.
KR860002269A (en) Process for preparing parenteral solutions
JPS5665079A (en) Stabilization of ground
ES463316A1 (en) water-soluble methyl benzimidazole-2-carbamate carbendazim fungicide- comprises carbendazim, a strong mineral acid and water
DE68902223D1 (en) AQUEOUS SOLUTIONS OF DOXORUBICIN.
KR920003967A (en) Gemfibrozil formulations
JPS5283913A (en) Carcinostatic polysaccharide aqueous solution
KR910004097A (en) Physiologically Preventive Compositions of Plants and Methods Using the Same
EP0351809A3 (en) Blood anticoagulant

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R071 Expiry of right

Ref document number: 587715

Country of ref document: EP