DE69230877T2 - Verfahren zur Kristallisierung von Alpha-L-Aspartyl-L-Phenylalaninmethylester - Google Patents

Verfahren zur Kristallisierung von Alpha-L-Aspartyl-L-Phenylalaninmethylester

Info

Publication number
DE69230877T2
DE69230877T2 DE69230877T DE69230877T DE69230877T2 DE 69230877 T2 DE69230877 T2 DE 69230877T2 DE 69230877 T DE69230877 T DE 69230877T DE 69230877 T DE69230877 T DE 69230877T DE 69230877 T2 DE69230877 T2 DE 69230877T2
Authority
DE
Germany
Prior art keywords
aspartyl
crystallization
alpha
methyl ester
phenylalanine methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230877T
Other languages
English (en)
Other versions
DE69230877D1 (de
Inventor
Sou Abe
Shinichi Kishimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of DE69230877D1 publication Critical patent/DE69230877D1/de
Publication of DE69230877T2 publication Critical patent/DE69230877T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/801—Peptide sweetners

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Seasonings (AREA)
DE69230877T 1991-10-30 1992-10-29 Verfahren zur Kristallisierung von Alpha-L-Aspartyl-L-Phenylalaninmethylester Expired - Fee Related DE69230877T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28459091 1991-10-30
JP4102918A JPH05178889A (ja) 1991-10-30 1992-04-22 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの晶析方法

Publications (2)

Publication Number Publication Date
DE69230877D1 DE69230877D1 (de) 2000-05-11
DE69230877T2 true DE69230877T2 (de) 2000-12-14

Family

ID=26443604

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230877T Expired - Fee Related DE69230877T2 (de) 1991-10-30 1992-10-29 Verfahren zur Kristallisierung von Alpha-L-Aspartyl-L-Phenylalaninmethylester

Country Status (5)

Country Link
US (2) US5425787A (de)
EP (1) EP0547342B1 (de)
JP (1) JPH05178889A (de)
CA (1) CA2081869C (de)
DE (1) DE69230877T2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0976762A1 (de) * 1998-07-29 2000-02-02 Daesang Corporation Kristalliserung von Alpha-L-aspartyl-L-phenylalaninmethylester
US6090972A (en) * 1998-11-12 2000-07-18 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester
US6657073B1 (en) 1999-08-18 2003-12-02 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester
US6225493B1 (en) * 2000-08-21 2001-05-01 The Nutrasweet Company Metal ion assisted N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester isomer resolution

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901871A (en) * 1973-09-21 1975-08-26 American Cyanamid Co Process of preparing ' -l-aspartyl-l-phenylalanine methyl ester
JPS58177952A (ja) * 1982-04-12 1983-10-18 Ajinomoto Co Inc Ｌ−α−アスパルチル−Ｌ−フエニルアラニンメチルエステルの晶析法
JPS59227849A (ja) * 1983-06-08 1984-12-21 Ajinomoto Co Inc Ｌ―α―アスパルチル―Ｌ―フェニルアラニンメチルエステル束状晶の晶析分離法
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
JPH07103154B2 (ja) * 1986-08-13 1995-11-08 東ソー株式会社 安定なα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造方法
EP0362706B1 (de) * 1988-10-03 1996-01-17 Ajinomoto Co., Inc. Verfahren zur Herstellung von trockenen IB Kristallen des alpha-L-Aspartyl-L-phenylalaninmethylesters, die eine verbesserte Löslichkeit besitzen
JPH0327398A (ja) * 1989-06-26 1991-02-05 Mitsui Toatsu Chem Inc α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの晶析方法
JP2946853B2 (ja) * 1991-05-09 1999-09-06 味の素株式会社 アスパルテームの晶析法
JP2970107B2 (ja) * 1991-05-23 1999-11-02 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法
JP2979761B2 (ja) * 1991-05-23 1999-11-15 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル塩酸塩の製造法
JP2927070B2 (ja) * 1991-05-23 1999-07-28 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法
JP3163661B2 (ja) * 1991-08-05 2001-05-08 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル、及びＬ−フェニルアラニン、Ｌ−アスパラギン酸の回収方法

Also Published As

Publication number Publication date
JPH05178889A (ja) 1993-07-20
EP0547342A1 (de) 1993-06-23
US5425787A (en) 1995-06-20
CA2081869A1 (en) 1993-05-01
US5501712A (en) 1996-03-26
DE69230877D1 (de) 2000-05-11
EP0547342B1 (de) 2000-04-05
CA2081869C (en) 2002-07-16

Similar Documents

Publication Publication Date Title
DE69025523T2 (de) Verfahren zur Kristallisation von Polyethylennaphthalat
DE69211141D1 (de) Verfahren zur alkoxylierung von estern
DE69227819D1 (de) Verfahren zur Veresterung von Salzen von Carbonsäuren
DE69216144T2 (de) Verfahren zur Herstellung von Alpha-Aspartyl-Phenylalanin-Methylester
DE59209261D1 (de) Verfahren zur Herstellung von substituierten 3-Alkoxy-acrylestern
DE69230877T2 (de) Verfahren zur Kristallisierung von Alpha-L-Aspartyl-L-Phenylalaninmethylester
DE69229459D1 (de) Verfahren zur Herstellung von Ketosäuren
DE69211756D1 (de) Verfahren zur Herstellung von alpha-L-aspartyl-L-phenylalaninmethylester
DE59401489D1 (de) Verfahren zur Herstellung von 5-Cyanvaleriansäureestern
DE69116149T2 (de) Verfahren zur Herstellung von Acrylestern
DE69333521D1 (de) Verfahren zur Kristallisierung von N2-((S)-1-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysyl-L-prolin
DE69215620T2 (de) Verfahren zur Herstellung von Methacrylatestern
DE69201516D1 (de) Verfahren zur Kristallisierung von Alpha-L-aspartyl-L-phenylalaninmethylester.
DE69226393T2 (de) Verfahren zur Herstellung von 2-Fluorisobuttersäureester
DE59301861D1 (de) Verfahren zur Herstellung von 2-Aryl-ethan-sulfonsäuren
DE69117911T2 (de) Verfahren zur Kristallisierung von N-t-Butoxycarbonyl-3-cyclohexyl-L-alaninmethylester
DE69400716T2 (de) Verfahren zur Hydroxykarbonylierung von laktonen
DE69117719T2 (de) Verfahren zur Herorientierung von Matrizen
DE69429851D1 (de) Verfahren zur Herstellung von alpha-L-Aspartyl-L-Phenylalaninmethylester
DE69429965D1 (de) Verfahren zur Herstellung von alpha-L-Aspartyl-L-Phenylalanin Methyl Ester
DE69311453T2 (de) Verfahren zur Herstellung von Alpha-L-Aspartyl-L-Phenylalaninmethylesterhydrochlorid
DE59209536D1 (de) Verfahren zur Herstellung von Tetrahydropyrancarbonsäureestern
DE69218737D1 (de) Verfahren zur Disproportionierung von Arylsilanen
DE69405193T2 (de) Verfahren zur Herstellung von Alkyl-3-phthalidylidenacetat
DE69117156D1 (de) Verfahren zur Herstellung von Alpha-L-aspartyl-L-phenylalanyl-methylester

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee