DE69229616D1 - Enzymatische Resolution von Alpha-tertiären-Karbonsäureestern - Google Patents

Enzymatische Resolution von Alpha-tertiären-Karbonsäureestern

Info

Publication number
DE69229616D1
DE69229616D1 DE69229616T DE69229616T DE69229616D1 DE 69229616 D1 DE69229616 D1 DE 69229616D1 DE 69229616 T DE69229616 T DE 69229616T DE 69229616 T DE69229616 T DE 69229616T DE 69229616 D1 DE69229616 D1 DE 69229616D1
Authority
DE
Germany
Prior art keywords
alpha
carboxylic acid
acid esters
enzymatic resolution
tertiary carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69229616T
Other languages
English (en)
Other versions
DE69229616T2 (de
Inventor
Christopher Yee
Todd Blythe
Alan Walts
Spencer Shames
Elizabeth Rogers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/697,152 external-priority patent/US5202260A/en
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of DE69229616D1 publication Critical patent/DE69229616D1/de
Application granted granted Critical
Publication of DE69229616T2 publication Critical patent/DE69229616T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69229616T 1991-05-08 1992-05-08 Enzymatische Resolution von Alpha-tertiären-Karbonsäureestern Expired - Fee Related DE69229616T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/697,152 US5202260A (en) 1991-05-08 1991-05-08 Resolution of α-tertiary carboxylic acid esters using lipase from Candida lipolytica
US87006192A 1992-04-17 1992-04-17

Publications (2)

Publication Number Publication Date
DE69229616D1 true DE69229616D1 (de) 1999-08-26
DE69229616T2 DE69229616T2 (de) 1999-11-11

Family

ID=27105949

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69229616T Expired - Fee Related DE69229616T2 (de) 1991-05-08 1992-05-08 Enzymatische Resolution von Alpha-tertiären-Karbonsäureestern

Country Status (5)

Country Link
US (1) US5492830A (de)
EP (1) EP0512848B1 (de)
JP (1) JPH0739391A (de)
CA (1) CA2068038A1 (de)
DE (1) DE69229616T2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580783A (en) * 1994-10-12 1996-12-03 E. I. Du Pont De Nemours And Company Enzymatic process for the preparation of chiral α-tertiary carboxylic acid esters
WO1996012035A1 (en) * 1994-10-12 1996-04-25 E.I. Du Pont De Nemours And Company Enzymatic process for the preparation of chiral-alpha-tertiary carboxylic acid esters
DE69914458T2 (de) 1998-02-17 2004-10-28 G.D. Searle & Co., Chicago Verfahren zur enzymatischen auflösung von laktamen
DE10004926A1 (de) * 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
US7299805B2 (en) * 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
CN101166524B (zh) 2005-04-28 2010-12-22 辉瑞有限公司 氨基酸衍生物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405159A (en) * 1964-11-17 1968-10-08 Merck & Co Inc Process for resolving racemic mixtures of optically-active enantiomorphs
US3895052A (en) * 1970-02-05 1975-07-15 Merck & Co Inc Diastereomers of n-acyl {60 -hydrazino-{62 -(substituted or unsubstituted phenyl)alkanoic acid derivatives
US3830827A (en) * 1970-03-23 1974-08-20 Merck & Co Inc L-alpha-hydrazino-alpha-substituted-beta-(3,4-dihydroxyphenyl)propionic acid substantially free of the d isomer,the lower alkyl esters thereof,and the pharmaceutically acceptable salts thereof,wherein the substituent is lower alkyl
US4262092A (en) * 1979-05-08 1981-04-14 Ethyl Corporation Process for producing N-acyl-D-phenylalanine ester
DE3785132T2 (de) * 1986-04-16 1993-10-21 Sumitomo Chemical Co Herstellung optisch aktiver cyclopropancarbonsäuren.
US5202260A (en) * 1991-05-08 1993-04-13 Genzyme Corporation Resolution of α-tertiary carboxylic acid esters using lipase from Candida lipolytica

Also Published As

Publication number Publication date
EP0512848A3 (en) 1993-09-01
JPH0739391A (ja) 1995-02-10
DE69229616T2 (de) 1999-11-11
EP0512848A2 (de) 1992-11-11
EP0512848B1 (de) 1999-07-21
US5492830A (en) 1996-02-20
CA2068038A1 (en) 1992-11-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee