DE69228277D1 - PACAP-Derivate mit c-AMP-produzierenden Eigenschaften - Google Patents

PACAP-Derivate mit c-AMP-produzierenden Eigenschaften

Info

Publication number
DE69228277D1
DE69228277D1 DE69228277T DE69228277T DE69228277D1 DE 69228277 D1 DE69228277 D1 DE 69228277D1 DE 69228277 T DE69228277 T DE 69228277T DE 69228277 T DE69228277 T DE 69228277T DE 69228277 D1 DE69228277 D1 DE 69228277D1
Authority
DE
Germany
Prior art keywords
group
lys
substituted
leu
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69228277T
Other languages
English (en)
Other versions
DE69228277T2 (de
Inventor
Chieko Kitada
Takuya Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69228277D1 publication Critical patent/DE69228277D1/de
Publication of DE69228277T2 publication Critical patent/DE69228277T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69228277T 1991-08-22 1992-08-19 PACAP-Derivate mit c-AMP-produzierenden Eigenschaften Expired - Fee Related DE69228277T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21116191 1991-08-22

Publications (2)

Publication Number Publication Date
DE69228277D1 true DE69228277D1 (de) 1999-03-11
DE69228277T2 DE69228277T2 (de) 1999-07-08

Family

ID=16601412

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69228277T Expired - Fee Related DE69228277T2 (de) 1991-08-22 1992-08-19 PACAP-Derivate mit c-AMP-produzierenden Eigenschaften

Country Status (5)

Country Link
US (2) US5623050A (de)
EP (1) EP0529487B1 (de)
AT (1) ATE176243T1 (de)
CA (1) CA2076593C (de)
DE (1) DE69228277T2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037321A (en) * 1995-05-03 2000-03-14 Biostar Inc. Fusion proteins comprising vasoactive intestinal peptide or PACAP
WO1996034958A1 (en) * 1995-05-03 1996-11-07 Biostar Inc. Vasoactive intestinal peptide
US6017533A (en) * 1996-04-25 2000-01-25 Shiseido Company, Ltd. Peptides having specific affinity to pituitary adenylate cyclase activating polypeptide type 1 receptors
US6242563B1 (en) 1998-07-20 2001-06-05 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Peptide analogues
CZ2001253A3 (cs) * 1998-07-20 2001-11-14 Societe De Conseils De Recherches Et D'application Peptidové analogy PACAP
WO2003018782A2 (en) * 2001-08-30 2003-03-06 Stem Cell Therapeutics Inc. Differentiation of neural stem cells and therapeutic use theeof
CA2460184A1 (en) 2001-09-14 2003-03-27 Stem Cell Therapeutics Inc. Prolactin induced increase in neural stem cell numbers and therapeutical use thereof
AU2002325710A1 (en) * 2001-09-18 2003-04-01 Stem Cell Therapeutics Inc. Effect of growth hormone and igf-1 on neural stem cells and therapeutic application
AU2003250697B2 (en) * 2002-07-30 2008-05-01 Stem Cell Therapeutics Inc. Oligodendrocyte production from multipotent neural stem cells
AU2003250705A1 (en) * 2002-07-31 2004-02-16 Stem Cell Therapeutics Inc. Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap)
EP1571155B1 (de) * 2002-11-27 2011-08-24 Ils Inc. Peptide und medizinische zusammensetzungen mit denselben
EP1740202B1 (de) * 2004-02-13 2012-05-09 Stem Cell Therapeutics Corp. Verwendung des luteinisierenden hormons (lh) und von choriongonadotrophin (hcg) für die proliferation von neuralen stammzellen und neurogenese
US7994131B2 (en) 2004-10-07 2011-08-09 Stem Cell Therapeutics Corp. Stimulation of proliferation of pluripotential stem cells through administration of pregnancy associated compounds
US7007328B1 (en) * 2004-11-05 2006-03-07 Terry Bailey System and apparatus for upper body support of a recumbent person
KR20080074108A (ko) 2005-09-27 2008-08-12 스템 셀 테라퓨틱스 코포레이션 프로락틴에 의해 조절되는 올리고덴드로사이트 전구체 세포증식
AU2007229301B2 (en) * 2006-03-17 2013-08-01 Stem Cell Therapeutics Corp. Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents
KR101838305B1 (ko) 2009-12-29 2018-03-13 큐알엔에이, 인크. ＮＲＦ1(Ｎｕｃｌｅａｒ Ｒｅｓｐｉｒａｔｏｒｙ Ｆａｃｔｏｒ 1)에 대한 천연 안티센스 전사체의 억제에 의한 핵 호흡 인자 1 관련된 질환의 치료
EP3712164A4 (de) * 2017-11-14 2021-08-18 Senju Pharmaceutical Co., Ltd. Pacap-stabilisiertes peptid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562175A (en) * 1984-02-03 1985-12-31 Ding Chang Synthetic peptides
US4605641A (en) * 1984-10-09 1986-08-12 Hoffmann-La Roche Inc. Synthetic vasoactive intestinal peptide analogs
JPS62246595A (ja) * 1986-04-17 1987-10-27 Eisai Co Ltd 気菅支拡張作用・降圧作用ペプタイド
US5128242A (en) * 1989-06-19 1992-07-07 The Administrators Of The Tulane Educational Fund Hypothalamic polypeptides with adenylate cyclase stimulating activity
US5198542A (en) * 1989-06-20 1993-03-30 Takeda Chemical Industries, Inc. Dna encoding a pitvitary adenylate cyclase activating protein and use thereof
EP0768090A3 (de) * 1990-07-18 1997-06-18 Takeda Chemical Industries Ltd Polypeptide mit c-AMP produzierender Aktivität zur Vorbeugung des neuronalen Zelltodes

Also Published As

Publication number Publication date
EP0529487A2 (de) 1993-03-03
ATE176243T1 (de) 1999-02-15
EP0529487B1 (de) 1999-01-27
DE69228277T2 (de) 1999-07-08
US5801147A (en) 1998-09-01
EP0529487A3 (en) 1994-06-22
US5623050A (en) 1997-04-22
CA2076593C (en) 2002-06-04
CA2076593A1 (en) 1993-02-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee