DE69227627D1 - Alifatische Propargylamine als selektive MAO-B Inhibitoren und als Neuroprotektive Agenzien - Google Patents
Alifatische Propargylamine als selektive MAO-B Inhibitoren und als Neuroprotektive AgenzienInfo
- Publication number
- DE69227627D1 DE69227627D1 DE69227627T DE69227627T DE69227627D1 DE 69227627 D1 DE69227627 D1 DE 69227627D1 DE 69227627 T DE69227627 T DE 69227627T DE 69227627 T DE69227627 T DE 69227627T DE 69227627 D1 DE69227627 D1 DE 69227627D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- propargylamines
- inhibitors
- sec
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- JKANAVGODYYCQF-UHFFFAOYSA-N prop-2-yn-1-amine Chemical class NCC#C JKANAVGODYYCQF-UHFFFAOYSA-N 0.000 title abstract 2
- 102000010909 Monoamine Oxidase Human genes 0.000 title 1
- 108010062431 Monoamine oxidase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000004090 neuroprotective agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical class 0.000 abstract 1
- 229940052764 dopaminergic anti-parkinson drug mao b inhibitors Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxy-substituted phenyl Chemical class 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 150000003457 sulfones Chemical class 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/23—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton the carbon skeleton containing carbon-to-carbon triple bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/663,018 US5169868A (en) | 1991-03-01 | 1991-03-01 | Aliphatic propargylamines as specific mao-b inhibitors |
| PCT/CA1992/000090 WO1992015551A1 (en) | 1991-03-01 | 1992-02-28 | Aliphatic propargylamines as selective mao-b inhibitors and as neuroprotective agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69227627D1 true DE69227627D1 (de) | 1998-12-24 |
| DE69227627T2 DE69227627T2 (de) | 1999-06-24 |
Family
ID=24660178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69227627T Expired - Fee Related DE69227627T2 (de) | 1991-03-01 | 1992-02-28 | Alifatische Propargylamine als selektive MAO-B Inhibitoren und als Neuroprotektive Agenzien |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5169868A (de) |
| EP (1) | EP0573498B1 (de) |
| JP (1) | JP3129733B2 (de) |
| AT (1) | ATE173459T1 (de) |
| AU (1) | AU658611B2 (de) |
| CA (1) | CA2105171A1 (de) |
| DE (1) | DE69227627T2 (de) |
| WO (1) | WO1992015551A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744500A (en) | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
| HUT63579A (en) * | 1991-12-20 | 1993-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing double-phase pharmaceutical compositions suitable for treating diseases occurring during neurodegenerative processes |
| DK0623344T3 (da) * | 1993-05-04 | 2000-12-18 | Ceva Sante Animale | Anvendelse af selegilin i veterinær medicin |
| AU1867095A (en) * | 1994-01-10 | 1995-08-01 | Technion Research & Development Foundation Ltd. | 1-aminoindan derivatives and compositions thereof |
| DE19708461A1 (de) * | 1997-02-18 | 1998-08-27 | Meulen Volker Prof Dr Ter | Verwendung aminerg wirkender Substanzen zur Herstellung eines Arzneimittels für die Behandlung viraler Infektionen des zentralen Nervensystems |
| US6111108A (en) * | 1997-07-01 | 2000-08-29 | Midwest Research Institute | Extraction of biologically active components from Camptotheca acuminata with supercritical fluids |
| US5840979A (en) | 1997-07-14 | 1998-11-24 | University Of Saskatchewan | Aliphatic propargylamines as cellular rescue agents |
| GB9715082D0 (en) * | 1997-07-17 | 1997-09-24 | Scherer Ltd R P | Treatment of attention deficit hyperactivity disorder and narcolepsy |
| CA2318693A1 (en) * | 1998-01-13 | 1999-07-22 | University Of Saskatchewan Technologies Inc. | Composition containing propargylamine for enhancing cancer therapy |
| US6809120B1 (en) | 1998-01-13 | 2004-10-26 | University Of Saskatchewan Technologies Inc. | Composition containing propargylamine for enhancing cancer therapy |
| US6984754B1 (en) | 1998-03-26 | 2006-01-10 | University Of Saskatchewan Technologies Inc. | Aliphatic amino carboxylic and amino phosphonic acids amino nitriles and amino tetrazoles as cellular rescue agents |
| EA003677B1 (ru) * | 1998-03-26 | 2003-08-28 | Юниверсити Оф Саскачеван Текнолоджиз Инк. | Алифатические аминокарбоновые и аминосульфоновые кислоты, аминонитрилы и аминотетразолы как агенты сохранения клеток |
| US6232326B1 (en) | 1998-07-14 | 2001-05-15 | Jodi A. Nelson | Treatment for schizophrenia and other dopamine system dysfunctions |
| US20040062787A1 (en) * | 2001-12-17 | 2004-04-01 | Daley William Lionel | Therapeutic combination of amlodipineand benazepril/benazeprilat |
| EP1565185A4 (de) * | 2002-11-07 | 2011-01-05 | Technion Res & Dev Foundation | Neuroprotektive eisenchelatoren und pharmazeutische zusammensetzungen damit |
| US8097608B2 (en) * | 2003-11-25 | 2012-01-17 | Technion Research And Development Foundation Ltd. | Methods for treatment of cardiovascular disorders and diseases |
| EP1686973A4 (de) | 2003-11-25 | 2009-03-25 | Technion Res & Dev Foundation | Zusammensetzungen und verfahren zur behandlung von kardiovaskulären erkrankungen und krankheiten |
| JP2005232148A (ja) * | 2004-02-03 | 2005-09-02 | Technion Research & Development Foundation Ltd | 神経保護剤としてプロパルギルアミンの使用 |
| EP2324886A1 (de) | 2005-07-29 | 2011-05-25 | Concert Pharmaceuticals Inc. | Neue deuterierte Analoga des Tadalafils |
| US8263655B2 (en) * | 2005-10-06 | 2012-09-11 | Technion Research And Development Foundation Ltd | Methods for treatment of renal failure |
| EP2053033A1 (de) | 2007-10-26 | 2009-04-29 | Bayer Schering Pharma AG | Verbindungen zur Verwendung bei der Abbildung, Diagnose und/oder Behandlung von Erkrankungen des zentralen Nervensystems oder von Tumoren |
| EP2309858A4 (de) | 2008-07-31 | 2011-09-14 | Dekel Pharmaceuticals Ltd | Zusammensetzungen und verfahren zur behandlung von entzündungserkrankungen |
| EP2421817A1 (de) * | 2009-04-23 | 2012-02-29 | Bayer Pharma Aktiengesellschaft | Neue vorstufenmoleküle für mit f-18 markierte pet-tracer |
| BR112012019374B1 (pt) | 2010-02-03 | 2022-01-11 | Pharma Two B Ltd | Composição farmacêutica oral e uso de um agente ativo para a preparação de uma composição farmacêutica oral para o tratamento de doenças neurodegenerativas |
| WO2012050971A2 (en) * | 2010-09-29 | 2012-04-19 | Teva Pharmaceutical Industries Ltd. | Propargyl-trifluoromethoxy-aminobenzothiazole derivatives, their preparation and use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB342651A (en) * | 1929-10-03 | 1931-02-03 | British Celanese | Improvements in the manufacture of artificial filaments, threads & the like by wet spinning methods |
| GB842651A (en) * | 1957-04-01 | 1960-07-27 | Lakeside Lab Inc | Novel acetylene compounds and process of preparing same |
| BE576562A (fr) * | 1958-03-21 | 1959-07-01 | Armour & Co | Solution stabilisée de chymotrypsine |
| US3000903A (en) * | 1959-09-15 | 1961-09-19 | Lakeside Lab Inc | Phenylalkylhydrazines and use as psychotherapeutics |
| US2997442A (en) * | 1960-03-30 | 1961-08-22 | Louise F Peale | Lubricating oil composition |
| FR1453844A (fr) * | 1965-03-19 | 1966-07-22 | Soc Ind Fab Antibiotiques Sifa | Nouvelles n-propynyl alcoylamines et leurs sels et procédé de préparation |
| US4201725A (en) * | 1974-05-20 | 1980-05-06 | Labaz | Secondary amines |
| US4650907A (en) * | 1985-12-05 | 1987-03-17 | Merrell Dow Pharmaceuticals Inc. | Nonaromatic fluoroallylamine MAO inhibitors |
| JPH03176457A (ja) * | 1989-12-04 | 1991-07-31 | Nippon Paint Co Ltd | 新規プロパルギル化合物、その製法ならびに該化合物を含む被覆材 |
-
1991
- 1991-03-01 US US07/663,018 patent/US5169868A/en not_active Expired - Fee Related
-
1992
- 1992-02-28 CA CA002105171A patent/CA2105171A1/en not_active Abandoned
- 1992-02-28 DE DE69227627T patent/DE69227627T2/de not_active Expired - Fee Related
- 1992-02-28 JP JP04504826A patent/JP3129733B2/ja not_active Expired - Fee Related
- 1992-02-28 AT AT92905512T patent/ATE173459T1/de not_active IP Right Cessation
- 1992-02-28 EP EP92905512A patent/EP0573498B1/de not_active Expired - Lifetime
- 1992-02-28 WO PCT/CA1992/000090 patent/WO1992015551A1/en active IP Right Grant
- 1992-02-28 US US08/108,653 patent/US5508311A/en not_active Expired - Fee Related
- 1992-02-28 AU AU13236/92A patent/AU658611B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA2105171A1 (en) | 1992-09-02 |
| JP3129733B2 (ja) | 2001-01-31 |
| US5508311A (en) | 1996-04-16 |
| EP0573498B1 (de) | 1998-11-18 |
| US5169868A (en) | 1992-12-08 |
| WO1992015551A1 (en) | 1992-09-17 |
| ATE173459T1 (de) | 1998-12-15 |
| AU658611B2 (en) | 1995-04-27 |
| AU1323692A (en) | 1992-10-06 |
| EP0573498A1 (de) | 1993-12-15 |
| JPH06505241A (ja) | 1994-06-16 |
| DE69227627T2 (de) | 1999-06-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |