DE69227366T2 - Durch 2- und 5- Alkyl und Phenyl substituierte 4-(1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5-hydroxy-2(5H)-Furanone als antiinflammatorische Mittel - Google Patents

Durch 2- und 5- Alkyl und Phenyl substituierte 4-(1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5-hydroxy-2(5H)-Furanone als antiinflammatorische Mittel

Info

Publication number
DE69227366T2
DE69227366T2 DE69227366T DE69227366T DE69227366T2 DE 69227366 T2 DE69227366 T2 DE 69227366T2 DE 69227366 T DE69227366 T DE 69227366T DE 69227366 T DE69227366 T DE 69227366T DE 69227366 T2 DE69227366 T2 DE 69227366T2
Authority
DE
Germany
Prior art keywords
alkyl
phenyl
hydroxy
substituted phenyl
carbons
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69227366T
Other languages
English (en)
Other versions
DE69227366D1 (de
Inventor
Gary Lee
Michael Garst
George Sachs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of DE69227366D1 publication Critical patent/DE69227366D1/de
Application granted granted Critical
Publication of DE69227366T2 publication Critical patent/DE69227366T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0814—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring is substituted at a C ring atom by Si
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
DE69227366T 1991-04-30 1992-04-29 Durch 2- und 5- Alkyl und Phenyl substituierte 4-(1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5-hydroxy-2(5H)-Furanone als antiinflammatorische Mittel Expired - Fee Related DE69227366T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/693,204 US5183906A (en) 1991-04-30 1991-04-30 2- and 5-alkyl and phenyl substituted 4-(1-hydroxy, 1-acyloxy or 1-carbamoyloxy)-5-hydroxy-2 (5h)-furanones as anti-inflammatory agents
PCT/US1992/003623 WO1992019610A1 (en) 1991-04-30 1992-04-29 2- and 5-alkyl and phenyl substituted 4-(1-hydroxy, 1-acyloxy or 1-carbamoyloxy)-5-hydroxy-2(5h)-furanones as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
DE69227366D1 DE69227366D1 (de) 1998-11-26
DE69227366T2 true DE69227366T2 (de) 1999-06-10

Family

ID=24783742

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69227366T Expired - Fee Related DE69227366T2 (de) 1991-04-30 1992-04-29 Durch 2- und 5- Alkyl und Phenyl substituierte 4-(1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5-hydroxy-2(5H)-Furanone als antiinflammatorische Mittel

Country Status (10)

Country Link
US (1) US5183906A (de)
EP (1) EP0579769B1 (de)
JP (1) JP3181054B2 (de)
AT (1) ATE172459T1 (de)
AU (1) AU1923892A (de)
CA (1) CA2109064A1 (de)
DE (1) DE69227366T2 (de)
ES (1) ES2124261T3 (de)
NO (1) NO933918L (de)
WO (1) WO1992019610A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268387A (en) * 1992-04-24 1993-12-07 Allergan, Inc. Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss
AU6556894A (en) * 1993-05-18 1994-12-12 Upjohn Company, The Bisphosphonate esters for treating gastric disorders
AU693110B2 (en) * 1993-08-19 1998-06-25 Warner-Lambert Company Substituted 2(5H)furanone, 2(5H)thiophenone and 2(5H)pyrrolone derivatives, their preparation and their use as endothelin antagonists
US5464865A (en) * 1993-12-22 1995-11-07 Ortho Pharmaceutical Corporation 4-aryl- and 4-arylthio-5-hydroxy-2(5H)-furanones as inhibitors of phospholipase A2
US5451686A (en) * 1994-04-15 1995-09-19 Allergan, Inc. 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents
US5639468A (en) * 1995-06-07 1997-06-17 University Of Southern California Method for reducing or preventing post-surgical adhesion formation using manoalide and analogs thereof
US5922759A (en) * 1996-06-21 1999-07-13 Warner-Lambert Company Butenolide endothelin antagonists
AU6603996A (en) * 1995-08-24 1997-03-19 Warner-Lambert Company Furanone endothelin antagonists
US5891892A (en) * 1996-10-29 1999-04-06 Warner-Lambert Company Small molecule biaryl compounds as inhibitors of endothelin converting enzyme
EP2147679B1 (de) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Zusammensetzungen für den Blut-Hirn-Schrankentransport
EP1768662A2 (de) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Immunstimulatoren kleiner moleküle und assays für deren nachweis
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
JP5564517B2 (ja) 2009-02-20 2014-07-30 ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ グルタチオンをベースとする薬物送達システム
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
FR2978963A1 (fr) 2011-08-11 2013-02-15 Ascorbix Nouveaux derives des furanones et composition pharmaceutique les contenant

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2359208A (en) * 1941-03-21 1944-09-26 Lilly Co Eli beta-substituted-delta alpha,beta-gamma-butyrolactones and beta-substituted-beta-hydroxy-gamma-butyrolactones and the methods of preparing them
US2359096A (en) * 1941-03-21 1944-09-26 Lilly Co Eli beta-substituted-delta alpha, beta-gamma-butyrolactones and beta-substituted - beta - hydroxy-gamma-butyrolactones and methods of preparing them
EP0133376B1 (de) * 1983-08-03 1988-07-27 The Regents Of The University Of California Synthetische analgetische und/oder antiinflammatorische Derivate des Manoalides
US4447445A (en) * 1983-08-03 1984-05-08 The Regents Of The University Of Calif. Manoalide, an anti-inflammatory analgesic marine natural product
US4789749A (en) * 1984-06-18 1988-12-06 The Regents Of The University Of California Manoalide analogs
US4874782A (en) * 1985-07-01 1989-10-17 Eli Lilly And Company Furanone derivatives
ZA864674B (en) * 1985-07-01 1988-02-24 Lilly Co Eli Furanone derivatives
US4786651A (en) * 1986-02-03 1988-11-22 Allergan, Inc. Treatment of cutaneous hyperproliferative dermatoses with manoalide
DE3615157A1 (de) * 1986-05-05 1987-11-12 Schwabe Willmar Gmbh & Co 5-arylalkyl-4-alkoxy-2(5h)-furanone, zwischenprodukte und verfahren zu ihrer herstellung sowie ihre anwendung als therapeutische wirkstoffe
US5089485A (en) * 1988-11-18 1992-02-18 Allergan, Inc. Anti-inflammatory furanones
CA1329390C (en) * 1987-06-08 1994-05-10 John N. Bonfiglio Anti-inflammatory furanones
US5037811A (en) * 1990-04-17 1991-08-06 Allergan, Inc. 4-(oxygen, sulfur or nitrogen substituted)-methyl 5-hydroxy-2(5H)-furanones as anti-inflammatory agents
US5043457A (en) * 1990-04-17 1991-08-27 Allergan, Inc. 2(5H)-furanones substituted in the 3 position, as Ca2+ channel antagonists and anti-inflammatory agents
US5059611A (en) * 1988-11-18 1991-10-22 Allergan, Inc. Anti-inflammatory 5-hydroxy-2-furanones
US4916241A (en) * 1988-06-06 1990-04-10 American Home Products Corporation Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones
JPH0222271A (ja) * 1988-07-11 1990-01-25 Kuraray Co Ltd 共役γ−オキシブテノライド化合物およびこれを有効成分とする抗潰瘍剤
US4935530A (en) * 1988-10-18 1990-06-19 Allergan, Inc. Process for preparing 5-substituted-3-furaldehydes
EP0369813A3 (de) * 1988-11-18 1991-02-27 Allergan, Inc Entzündungshemmende Furanone
JPH0356472A (ja) * 1988-12-07 1991-03-12 Allergan Inc 抗炎症５―ヒドロキシ―２―フラノンおよびその用途
US5045564A (en) * 1988-12-07 1991-09-03 Allergan, Inc. Anti-inflammatory 2-furanones
US5013850A (en) * 1990-03-30 1991-05-07 Allergan, Inc. 4-ethyl and 4-ethenyl-5-hydroxy-2(5H)-furanones substituted on alpha carbon of the ethyl or ethenyl side chain with a long chain alkyl group and on the beta carbon with a polar group, as anti-inflammatory agents

Also Published As

Publication number Publication date
JPH06507171A (ja) 1994-08-11
CA2109064A1 (en) 1992-10-31
ATE172459T1 (de) 1998-11-15
NO933918L (no) 1993-12-28
EP0579769A1 (de) 1994-01-26
EP0579769B1 (de) 1998-10-21
ES2124261T3 (es) 1999-02-01
WO1992019610A1 (en) 1992-11-12
AU1923892A (en) 1992-12-21
DE69227366D1 (de) 1998-11-26
US5183906A (en) 1993-02-02
NO933918D0 (no) 1993-10-29
JP3181054B2 (ja) 2001-07-03

Similar Documents

Publication Publication Date Title
DE69227366T2 (de) Durch 2- und 5- Alkyl und Phenyl substituierte 4-(1-hydroxy, 1-acyloxy oder 1-carbamoyloxy)-5-hydroxy-2(5H)-Furanone als antiinflammatorische Mittel
ES527954A1 (es) Un procedimiento para preparar isoxazoles
AU2289492A (en) Cosmetic composition
ES2075389T3 (es) Pigmentos laminados mejorados.
AU6100001A (en) High strength polymers and aerospace sealants therefrom
ES2084129T3 (es) Nuevas calconas heterociclicas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
DE3764885D1 (de) Neue 5-alkoxy-2,4-diamino-alkylbenzole sowie haarfaerbemittel mit 5-alkoxy-2,4-diamino-alkyl-benzolen.
ATE165972T1 (de) 2(5h)- in position 3-substituierte furanone als ca 2+ antagonisten und entzündungshemmende mittel
DK0855401T3 (da) Kontrastsammensætninger til kernemagnetisk resonans
DE68906422D1 (de) Fluessigkristall-verbindung.
DK0460488T3 (da) Svovlholdige heterocykliske forbindelser
DK0531091T3 (da) Biologisk nedbrydelig copolyester af 4-hydroxyprolin og farmaceutisk præparat indeholdende samme
EP0368933A4 (de) Zusammensetzungen, die mit 1-oxo- oder thiokohlenwassserstoff substituierte azacycloalkane enthalten.
SE7714614L (sv) Sett att framstella nya 11beta-substituerade 1,3,5(10)-triensteroidderivat
DE3788886T2 (de) Makrolid-Verbindungen.
IE830469L (en) Fungicidal cyanopropenoates
DK61785A (da) 2-alkoxyaminosulfonylbenzensulfonylurinstofderivater, deres fremstilling og anvendelse som herbicider
EP0285980A3 (de) Riechstoffe und diese enthaltende Riechstoffkompositionen
DE3172309D1 (en) Substituted 3,5-diamino-1,2,4-oxadiazoles and 3,5-diamino-1,2,4-thiadiazoles, their preparation and pharmaceutical compositions containing them
ATE8059T1 (de) Verwendung einer gruppe von dioxa-alkyltricyclododecenen als riechstoffe; diese enthaltende riechstoffkompositionen; neue dioxa- alkyl-tricyclododecene dieser gruppe.
GB2020656A (en) Tricyclo- alpha , beta -unsaturated ketones
JPS5432471A (en) 8-aklyl-3-oxo-2-oxabicyclo(3,2,1)-octanes, their preparation, and perfume composition containing the same
FI812777L (fi) Foerfarande foer framstaellning av nya cardenolid-bis-digitoxosider
ATE233748T1 (de) Benzo(b)pyranderivate verwendbar als äusserlich anzuwendende hautbehandlungsmittel
SE8004622L (sv) Acylaminobensoesyraderivat

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee