DE69223965T2 - Anticonvulsives aminosäurederivat - Google Patents

Anticonvulsives aminosäurederivat

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Publication number
DE69223965T2
DE69223965T2 DE69223965T DE69223965T DE69223965T2 DE 69223965 T2 DE69223965 T2 DE 69223965T2 DE 69223965 T DE69223965 T DE 69223965T DE 69223965 T DE69223965 T DE 69223965T DE 69223965 T2 DE69223965 T2 DE 69223965T2
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Germany
Prior art keywords
anticonvulsive
amino acid
acid derivative
compounds
cns
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69223965T
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English (en)
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DE69223965D1 (de
Inventor
Harold Kohn
Darrell Watson
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Research Corp Technologies Inc
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Research Corp Technologies Inc
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Publication of DE69223965T2 publication Critical patent/DE69223965T2/de
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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DE69223965T 1991-06-04 1992-06-04 Anticonvulsives aminosäurederivat Expired - Lifetime DE69223965T2 (de)

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US07/710,610 US5378729A (en) 1985-02-15 1991-06-04 Amino acid derivative anticonvulsant
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EP0592490B1 (de) 1998-01-07
JP3330374B2 (ja) 2002-09-30
JP2002241355A (ja) 2002-08-28
AU2162192A (en) 1993-01-08
ATE161824T1 (de) 1998-01-15
DE69223965D1 (de) 1998-02-12
CA2110693C (en) 2003-05-20
EP0592490A4 (en) 1994-08-17
EP0592490A1 (de) 1994-04-20
WO1992021648A1 (en) 1992-12-10
US5378729A (en) 1995-01-03
JPH06510985A (ja) 1994-12-08
AU657985B2 (en) 1995-03-30

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