DE69221473T2 - Bis-naphthalimide, die amide und thioamide als linker enthalten als krebsmittel - Google Patents

Bis-naphthalimide, die amide und thioamide als linker enthalten als krebsmittel

Info

Publication number
DE69221473T2
DE69221473T2 DE69221473T DE69221473T DE69221473T2 DE 69221473 T2 DE69221473 T2 DE 69221473T2 DE 69221473 T DE69221473 T DE 69221473T DE 69221473 T DE69221473 T DE 69221473T DE 69221473 T2 DE69221473 T2 DE 69221473T2
Authority
DE
Germany
Prior art keywords
bis
thioamids
naphthalimides
linkers
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69221473T
Other languages
English (en)
Other versions
DE69221473D1 (de
Inventor
Jung-Hui Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Application granted granted Critical
Publication of DE69221473D1 publication Critical patent/DE69221473D1/de
Publication of DE69221473T2 publication Critical patent/DE69221473T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69221473T 1991-03-27 1992-03-25 Bis-naphthalimide, die amide und thioamide als linker enthalten als krebsmittel Expired - Fee Related DE69221473T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/676,062 US5206250A (en) 1991-03-27 1991-03-27 Bis-naphthalimides containing amide and thioamide linkers as anticancer agents
PCT/US1992/002137 WO1992017454A1 (en) 1991-03-27 1992-03-25 Bis-naphthalimides containing amide and thioamide linkers as anticancer agents

Publications (2)

Publication Number Publication Date
DE69221473D1 DE69221473D1 (de) 1997-09-11
DE69221473T2 true DE69221473T2 (de) 1998-01-22

Family

ID=24713079

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69221473T Expired - Fee Related DE69221473T2 (de) 1991-03-27 1992-03-25 Bis-naphthalimide, die amide und thioamide als linker enthalten als krebsmittel

Country Status (10)

Country Link
US (1) US5206250A (de)
EP (1) EP0577745B1 (de)
JP (1) JP2701980B2 (de)
AT (1) ATE156481T1 (de)
AU (1) AU1752592A (de)
CA (1) CA2106996A1 (de)
DE (1) DE69221473T2 (de)
DK (1) DK0577745T3 (de)
ES (1) ES2104917T3 (de)
WO (1) WO1992017454A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2125142A1 (en) * 1991-12-11 1993-06-24 Jung-Hui Sun Highly water soluble bis-naphthalimides useful as anticancer agents
US5235045A (en) * 1992-03-19 1993-08-10 Microbiomed Corporation Non-azo naphthalimide dyes
US5359070A (en) * 1993-02-11 1994-10-25 The Du Pont Merck Pharmaceutical Company Unsymmetrical bis-imides as anticancer agents
US5416089A (en) * 1993-06-24 1995-05-16 The Du Pont Merck Pharmaceutical Company Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US5766600A (en) * 1993-08-09 1998-06-16 Microbiomed Corporation Non-azo naphtalimide dyes and uses for same
AU7831694A (en) * 1993-09-24 1995-04-10 Du Pont Merck Pharmaceutical Company, The Improved methods for preparing bis-imide compounds
US5561042A (en) * 1994-07-22 1996-10-01 Cancer Therapy And Research Center Diamine platinum naphthalimide complexes as antitumor agents
US5604095A (en) * 1994-07-22 1997-02-18 Cancer Therapy & Research Center Unsymmetrically linked bisnaphthalimides as antitumor agents
US5641782A (en) * 1995-02-16 1997-06-24 The Dupont Merck Pharmaceutical Company 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146720A (en) * 1976-10-27 1979-03-27 Laboratorios Made, S.A. N-aminoethyl-substituted-3-nitronaphthalimides
ES459497A1 (es) * 1977-06-04 1978-04-16 Made Labor Sa Un metodo para la preparacion industrial de naftalimidas y sus derivados.
EP0125439B1 (de) * 1983-04-01 1990-01-24 Warner-Lambert Company 3,6-Disubstituierte-1,8-Naphthalimide, Verfahren zu ihrer Herstellung und ihre Verwendung
DE3604827A1 (de) * 1986-02-15 1987-08-20 Bayer Ag Elektrophotographische toner
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents

Also Published As

Publication number Publication date
JPH06506226A (ja) 1994-07-14
WO1992017454A1 (en) 1992-10-15
JP2701980B2 (ja) 1998-01-21
DE69221473D1 (de) 1997-09-11
ATE156481T1 (de) 1997-08-15
CA2106996A1 (en) 1992-09-28
US5206250A (en) 1993-04-27
ES2104917T3 (es) 1997-10-16
EP0577745A1 (de) 1994-01-12
DK0577745T3 (da) 1997-09-22
EP0577745B1 (de) 1997-08-06
AU1752592A (en) 1992-11-02

Similar Documents

Publication Publication Date Title
EE200000320A (et) Uudsed ühendid
SE9704544D0 (sv) Novel compounds
DE69711640T2 (de) Naphthopyrane, zusammensetzungen und artikel die diese enthalten
DE69227581D1 (de) Zahnputzmittel, die antibakterielle quartäre ammoniumverbindungen und ausgewählte calcium-schleifmittel enthalten
IL128425A0 (en) Taxane derivatives their preparation and pharmaceutical compositions containing them
IL105715A0 (en) 7beta substituted-4-aza-5alpha-androstan-3-ones and pharmaceutical compositions containing them
BR1100987A (pt) Composto, composição farmacêutica da matéria, e, composição veterinária
FI960849A0 (fi) Metallikomplekseja sisältäviä farmaseuttisia koostumuksia
IL123002A0 (en) 1-Phenyl-2- phenylacetoxy- ethanone derivatives
HUT68963A (en) Novel 4-arylpiperazines and 4-arylpiperidines, pharmaceutical compositions comprising them and the proces for producing thereof
AP9600804A0 (en) Therapeutic amides.
NO302359B1 (no) 7-(substituerte)-9-£(substituerte glycyl)amido|-6-demetyl-6-deoksy-tetracykliner, farmasöytiske preparater inneholdende dem, og mellomprodukter
IL133831A0 (en) Pharmaceutical compositions containing proteasome inhibitors
DE69908819D1 (de) Glycopeptid-derivate und pharmazeutische zusammensetzungen, die sie enthalten
IL117091A0 (en) Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
IL103510A0 (en) Pharmaceutical compositions containing antibodies for causing immunosuppression
HRP930239A2 (en) Anti-inflamatory 4-aminophenol derivatives
ATE218142T1 (de) Nitratester von corticoid verbindungen und die therapeutische verwendungen davon
DE69221473D1 (de) Bis-naphthalimide, die amide und thioamide als linker enthalten als krebsmittel
DE69410614D1 (de) Bis-naphthalimide für die behandlung von krebs
IL129359A0 (en) Bi-aromatic compounds bound by a heteroethynylene radical and pharmaceutical and cosmetic compositions containing same
HUP9601977A3 (en) Mixtures containing amino acides and amides, process for producing the amides, and pharmaceutical compositions containing these mixtures and/or amides
RU95116448A (ru) Производные пирролидина, способ их получения и содержащие их лекарственные средства
IL95166A0 (en) Renin-inhibiting amino oligohydroxy derivatives
AU8744691A (en) N-((2-thenoylmercapto-3-methyl)-butanoyl)-homocysteine thiolactone, a process for the preparation thereof and pharmaceutical compositions containing it

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DU PONT PHARMACEUTICALS CO., WILMINGTON, DEL., US

8339 Ceased/non-payment of the annual fee