DE69208068D1 - Neue tricyclischen Steroid-Analogen - Google Patents

Neue tricyclischen Steroid-Analogen

Info

Publication number
DE69208068D1
DE69208068D1 DE69208068T DE69208068T DE69208068D1 DE 69208068 D1 DE69208068 D1 DE 69208068D1 DE 69208068 T DE69208068 T DE 69208068T DE 69208068 T DE69208068 T DE 69208068T DE 69208068 D1 DE69208068 D1 DE 69208068D1
Authority
DE
Germany
Prior art keywords
steroid analogs
fluoroalkyl
carbonyl
alkyl
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69208068T
Other languages
English (en)
Other versions
DE69208068T2 (de
Inventor
Douglas Floyd Covey
Yuefei Hu
Charles Francis Zorumski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Application granted granted Critical
Publication of DE69208068D1 publication Critical patent/DE69208068D1/de
Publication of DE69208068T2 publication Critical patent/DE69208068T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69208068T 1991-12-20 1992-12-18 Neue tricyclischen Steroid-Analogen Expired - Fee Related DE69208068T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/811,208 US5206415A (en) 1991-12-20 1991-12-20 Tricyclic steroid analogs

Publications (2)

Publication Number Publication Date
DE69208068D1 true DE69208068D1 (de) 1996-03-14
DE69208068T2 DE69208068T2 (de) 1996-05-30

Family

ID=25205887

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69208068T Expired - Fee Related DE69208068T2 (de) 1991-12-20 1992-12-18 Neue tricyclischen Steroid-Analogen

Country Status (7)

Country Link
US (3) US5206415A (de)
EP (1) EP0548824B1 (de)
JP (1) JP3238962B2 (de)
AT (1) ATE133654T1 (de)
CA (1) CA2085819A1 (de)
DE (1) DE69208068T2 (de)
DK (1) DK0548824T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5434274A (en) * 1991-12-20 1995-07-18 Washington University Benz(epsilon)indene compounds
US5696199A (en) * 1995-12-07 1997-12-09 Minnesota Mining And Manufacturing Company Pressure-sensitive adhesive polyacrylate polymer and method of making
US6787530B1 (en) 1996-08-23 2004-09-07 Monash University Use of pregnane-diones as analgesic agents
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
WO1999066915A2 (en) 1998-06-23 1999-12-29 Southern Illinois University At Carbondale Therapeutic applications of estrogenic carboxylic acids
US6653471B2 (en) 2000-08-07 2003-11-25 Neurogen Corporation Heterocyclic compounds as ligands of the GABAA receptor
US20020072509A1 (en) * 2000-10-11 2002-06-13 Stein Donald Gerald Methods for the treatment of a traumatic central nervous system injury
AR031473A1 (es) * 2000-11-20 2003-09-24 Lundbeck & Co As H Intensificadores de gaba en el tratamiento de enfermedades relacionadas con una reducida actividad neuroesteroide
US20030037354A1 (en) * 2001-08-02 2003-02-20 Ornitz David M. Animal model with disrupted Fgf14 gene
US7473687B2 (en) * 2005-03-24 2009-01-06 Emory University Methods for the treatment of a traumatic central nervous system injury
JP5295755B2 (ja) 2005-03-24 2013-09-18 エモリー ユニバーシティー プロゲステロンによる外傷性脳損傷の治療のための投薬レジメン
EP1889198B1 (de) 2005-04-28 2014-11-26 Proteus Digital Health, Inc. Pharma-informatiksystem
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
DK3395372T3 (da) 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
EP2427178B1 (de) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermale freisetzungszusammensetzung mit wirkstoff-calciumphosphat-partikelkomplexen und anwendungsverfahren

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2830075A (en) * 1954-05-10 1958-04-08 Farinacci Nicholas Thomas 2-alpha-carbonylated 8, 13-dimethyl polyhydrophenanthrene compounds and preparation thereof
US2830325A (en) * 1956-05-10 1958-04-15 Davol Rubber Co Mold for forming open-ended bulbs
US3293284A (en) * 1964-08-07 1966-12-20 Searle & Co 1, 2-seco-alpha-nor-5 alpha-androstane-1, 2, 17 beta-triols, 17-alkylated-1, 2-seco-alpha-nor-5 alpha-androstane-1, 2, 17 beta-triols and esters thereof
US3281431A (en) * 1964-09-28 1966-10-25 Searle & Co 17-oxygenated-2-thia-5alpha-androstanes and derivatives thereof
FR1526962A (fr) * 1967-01-06 1968-05-31 Roussel Uclaf Nouveau procédé de préparation d'un composé gonatriénique et produits en résultant
IL32496A (en) * 1968-07-24 1973-06-29 Roussel Uclaf 1-oxa-a-nor-androstanes
US3821288A (en) * 1971-07-01 1974-06-28 Syntex Inc 16,17-seco-a-nor steroids
GB2068363A (en) * 1980-01-30 1981-08-12 Sarabhai Ambalal Ets Substituted Benzhydrindanes
US4874891A (en) * 1986-05-01 1989-10-17 Washington University Open "D" ring hormone analogs
AU609927B2 (en) * 1987-08-25 1991-05-09 Kelvin W. Gee Compositions and methods for alleviating stress, anxiety and seizure activity

Also Published As

Publication number Publication date
EP0548824A1 (de) 1993-06-30
EP0548824B1 (de) 1996-01-31
US5292906A (en) 1994-03-08
JP3238962B2 (ja) 2001-12-17
DE69208068T2 (de) 1996-05-30
ATE133654T1 (de) 1996-02-15
DK0548824T3 (da) 1996-02-19
US5344826A (en) 1994-09-06
JPH05306257A (ja) 1993-11-19
US5206415A (en) 1993-04-27
CA2085819A1 (en) 1993-06-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee