DE69204497D1 - Verfahren und Zwischenprodukte zur Herstellung von 2,2-Dimethyl-2,3-Dihydrobenzofuran-7-Carbonsäuren. - Google Patents

Verfahren und Zwischenprodukte zur Herstellung von 2,2-Dimethyl-2,3-Dihydrobenzofuran-7-Carbonsäuren.

Info

Publication number
DE69204497D1
DE69204497D1 DE69204497T DE69204497T DE69204497D1 DE 69204497 D1 DE69204497 D1 DE 69204497D1 DE 69204497 T DE69204497 T DE 69204497T DE 69204497 T DE69204497 T DE 69204497T DE 69204497 D1 DE69204497 D1 DE 69204497D1
Authority
DE
Germany
Prior art keywords
dihydrobenzofuran
intermediates
dimethyl
carboxylic acids
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69204497T
Other languages
English (en)
Other versions
DE69204497T2 (de
Inventor
Christopher Randall Schmid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69204497D1 publication Critical patent/DE69204497D1/de
Application granted granted Critical
Publication of DE69204497T2 publication Critical patent/DE69204497T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/88Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69204497T 1991-03-07 1992-03-05 Verfahren und Zwischenprodukte zur Herstellung von 2,2-Dimethyl-2,3-Dihydrobenzofuran-7-Carbonsäuren. Expired - Fee Related DE69204497T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/666,279 US5142069A (en) 1991-03-07 1991-03-07 Process of preparing 2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylic acids

Publications (2)

Publication Number Publication Date
DE69204497D1 true DE69204497D1 (de) 1995-10-12
DE69204497T2 DE69204497T2 (de) 1996-03-21

Family

ID=24673565

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69204497T Expired - Fee Related DE69204497T2 (de) 1991-03-07 1992-03-05 Verfahren und Zwischenprodukte zur Herstellung von 2,2-Dimethyl-2,3-Dihydrobenzofuran-7-Carbonsäuren.

Country Status (16)

Country Link
US (1) US5142069A (de)
EP (1) EP0502735B1 (de)
JP (1) JPH04338381A (de)
KR (1) KR100193973B1 (de)
AT (1) ATE127461T1 (de)
BR (1) BR9200768A (de)
CA (1) CA2062329A1 (de)
DE (1) DE69204497T2 (de)
DK (1) DK0502735T3 (de)
ES (1) ES2078652T3 (de)
GR (1) GR3017875T3 (de)
HU (1) HU212786B (de)
IE (1) IE67382B1 (de)
IL (1) IL101149A (de)
MX (1) MX9200962A (de)
TW (1) TW198014B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723103A (en) * 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3860619A (en) * 1969-05-09 1975-01-14 Novo Terapeutisk Labor As Sulphonylurea derivatives
WO1984003281A1 (en) * 1983-02-19 1984-08-30 Beecham Group Plc Azabicycloalkyl benzamide and anilide derivatives
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
CA1297877C (en) * 1983-12-22 1992-03-24 Daniel Lednicer Benzofurancarboxamides useful as antiemetic or antipsychotic agents
US4921982A (en) * 1988-07-21 1990-05-01 Eli Lilly And Company 5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT3 antagonists

Also Published As

Publication number Publication date
MX9200962A (es) 1992-09-01
HU9200745D0 (en) 1992-05-28
EP0502735A1 (de) 1992-09-09
TW198014B (de) 1993-01-11
BR9200768A (pt) 1992-11-17
HUT61008A (en) 1992-11-30
DE69204497T2 (de) 1996-03-21
IL101149A0 (en) 1992-11-15
KR100193973B1 (ko) 1999-06-15
US5142069A (en) 1992-08-25
IE920737A1 (en) 1992-09-09
GR3017875T3 (en) 1996-01-31
JPH04338381A (ja) 1992-11-25
ES2078652T3 (es) 1995-12-16
EP0502735B1 (de) 1995-09-06
KR920018038A (ko) 1992-10-21
DK0502735T3 (da) 1996-04-09
ATE127461T1 (de) 1995-09-15
IL101149A (en) 1996-09-12
HU212786B (en) 1996-11-28
CA2062329A1 (en) 1992-09-08
IE67382B1 (en) 1996-03-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee