DE69133087T2 - Kombination aus IGF-I und TGF-beta zur Knochenregenerierung - Google Patents
Kombination aus IGF-I und TGF-beta zur KnochenregenerierungInfo
- Publication number
- DE69133087T2 DE69133087T2 DE69133087T DE69133087T DE69133087T2 DE 69133087 T2 DE69133087 T2 DE 69133087T2 DE 69133087 T DE69133087 T DE 69133087T DE 69133087 T DE69133087 T DE 69133087T DE 69133087 T2 DE69133087 T2 DE 69133087T2
- Authority
- DE
- Germany
- Prior art keywords
- beta
- igf
- tgf
- combination
- bone regeneration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 title abstract 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 title abstract 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 title abstract 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 2
- 230000010478 bone regeneration Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 102000048143 Insulin-Like Growth Factor II Human genes 0.000 abstract 1
- 108090001117 Insulin-Like Growth Factor II Proteins 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53064990A | 1990-05-30 | 1990-05-30 | |
| PCT/US1991/003829 WO1991018622A1 (en) | 1990-05-30 | 1991-05-30 | Wound healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69133087D1 DE69133087D1 (de) | 2002-09-19 |
| DE69133087T2 true DE69133087T2 (de) | 2003-04-03 |
Family
ID=24114431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69133087T Expired - Lifetime DE69133087T2 (de) | 1990-05-30 | 1991-05-30 | Kombination aus IGF-I und TGF-beta zur Knochenregenerierung |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0531425B1 (de) |
| JP (1) | JP3377524B2 (de) |
| AT (1) | ATE222117T1 (de) |
| CA (1) | CA2082420C (de) |
| DE (1) | DE69133087T2 (de) |
| ES (1) | ES2178633T3 (de) |
| WO (1) | WO1991018622A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5288628A (en) * | 1992-06-24 | 1994-02-22 | The Procter & Gamble Company | Rat osteosarcoma cell line OSR4TR1 |
| US5292656A (en) * | 1992-06-24 | 1994-03-08 | The Procter & Gamble Company | Rat osteosarcoma cell line OSR-6 |
| US5286645A (en) * | 1992-06-24 | 1994-02-15 | The Procter & Gamble Company | Rat osteosarcoma cell line osr3tr1 |
| US5286643A (en) * | 1992-06-24 | 1994-02-15 | The Procter & Gamble Company | Rat osteosarcoma cell line OSR-8 |
| US5286644A (en) * | 1992-06-24 | 1994-02-15 | The Procter & Gamble Company | Rat osteosarcoma cell line OSR-2 |
| US5264358A (en) * | 1992-06-24 | 1993-11-23 | The Procter & Gamble Company | Rat osteosarcoma cell line OSR9TR1 |
| KR100385293B1 (ko) * | 2000-05-13 | 2003-05-23 | 주식회사 리젠 바이오텍 | βｉｇ-ｈ3의 일부 도메인을 이용한 세포 부착 및 창상치유 방법 |
| GB2369572A (en) | 2000-11-29 | 2002-06-05 | Raft Trustees Ltd | Wound treatment composition comprising insulin |
| JP2014156410A (ja) * | 2013-02-14 | 2014-08-28 | Nagoya Univ | 組織形成用組成物及びその利用 |
| MX2017004520A (es) | 2014-10-14 | 2018-03-15 | Lynch Samuel | Composiciones para tratar heridas. |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6034997A (ja) * | 1983-05-09 | 1985-02-22 | ジヨージ、ジヨセフ、トダロ | 生物学的活性ポリペプチド類 |
| JPS61291521A (ja) * | 1983-06-03 | 1986-12-22 | アメリカ合衆国 | ヒト血小板もしくはヒト胎盤由来の精製β型トランスホ−ミング成長因子 |
| US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
| ATE84065T1 (de) * | 1986-10-09 | 1993-01-15 | Fujisawa Pharmaceutical Co | Expressionsvektor fuer menschlichen insulinaehnlichen wachstumsfaktor-i. |
| NZ235556A (en) * | 1986-11-05 | 1991-06-25 | Ethicon Inc | Breast milk substitute containing recombinant human egf |
| KR960005708B1 (ko) * | 1986-11-14 | 1996-05-01 | 인스티튜트 오브 몰레큘러 바이올로지, 인코오포레이티드 | 외상 치료 및 뼈 재생용 조성물 |
| AU1340688A (en) * | 1987-01-30 | 1988-08-24 | Techne Corporation | Transforming growth factor-beta |
| US4885163A (en) * | 1987-02-24 | 1989-12-05 | Eli Lilly And Company | Topical use of IGF-II for wound healing |
| NZ226171A (en) * | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
| EP0323842A3 (de) * | 1988-01-07 | 1990-04-25 | Otsuka Pharmaceutical Co., Ltd. | Methode für die Säuberung von umbildendem Wachstums-Faktor-Beta |
| US4983581A (en) * | 1988-05-20 | 1991-01-08 | Institute Of Molecular Biology, Inc. | Wound healing composition of IGF-I and TGF-β |
| US4950483A (en) * | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
| EP0424416B1 (de) * | 1988-07-15 | 1995-07-19 | Central Sydney Area Health Service | Säureempfindliche subeinheit eines insulinähnlichen wachstumfaktors-bindeprotein-komplexes |
| NZ236618A (en) * | 1990-01-03 | 1997-06-24 | Ciba Geigy Ag | Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound |
-
1991
- 1991-05-30 AT AT91910904T patent/ATE222117T1/de not_active IP Right Cessation
- 1991-05-30 CA CA002082420A patent/CA2082420C/en not_active Expired - Lifetime
- 1991-05-30 EP EP91910904A patent/EP0531425B1/de not_active Expired - Lifetime
- 1991-05-30 WO PCT/US1991/003829 patent/WO1991018622A1/en active IP Right Grant
- 1991-05-30 JP JP51086191A patent/JP3377524B2/ja not_active Expired - Lifetime
- 1991-05-30 DE DE69133087T patent/DE69133087T2/de not_active Expired - Lifetime
- 1991-05-30 ES ES91910904T patent/ES2178633T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2178633T3 (es) | 2003-01-01 |
| CA2082420A1 (en) | 1991-12-01 |
| CA2082420C (en) | 2004-07-20 |
| EP0531425A1 (de) | 1993-03-17 |
| DE69133087D1 (de) | 2002-09-19 |
| EP0531425A4 (en) | 1997-08-27 |
| JPH05507488A (ja) | 1993-10-28 |
| JP3377524B2 (ja) | 2003-02-17 |
| WO1991018622A1 (en) | 1991-12-12 |
| EP0531425B1 (de) | 2002-08-14 |
| ATE222117T1 (de) | 2002-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX170454B (es) | Una composicion para cicatrizacion de heridas y regeneracion de huesos y metodo para prepararla | |
| DE68917300T2 (de) | Heilung von wunden. | |
| PT1114644E (pt) | Composicao compreendendo insulina e factor-i de crescimento do tipo insulina (igf-i) | |
| DE69133087T2 (de) | Kombination aus IGF-I und TGF-beta zur Knochenregenerierung | |
| DE69517714D1 (de) | Klebstoffzusammensetzung für chirurgische Zwecke enthaltend nichtvernetztes und durch oxidativen Abbau modifiziertes Kollagen | |
| DE69132918D1 (de) | Gewebeabdeckung und wachstumsfaktor enthaltende verbindungen zur förderung beschleunigter wundheilung | |
| ATE473995T1 (de) | Verwendung von angiotensin-ii-analogen zur gewebewiederherstellung | |
| ES2067720T3 (es) | Composicion y metodo para el tratamiento de la osteoporosis en mamiferos. | |
| ATE156363T1 (de) | Wundheilung | |
| DE69215445T2 (de) | Verfahren zur Herstellung von Betazeolith | |
| ATE70715T1 (de) | Bindungsinduzierende komposition. | |
| GR910100515A (el) | Θεραπευτικές συν?έσεις πληγών που περιέχουν παράγοντα ανάπτυξης ινοβλαστών και ασκορβικόν οξύ. | |
| DE69208208T2 (de) | Verfahren zur herstellung von gereinigtem naphthalendikarbonsäuredimethylester | |
| ATE195424T1 (de) | Verfahren zur verbesserung der wundheilung und gewebeerneuerung | |
| DE69026087D1 (de) | Substituierte 2-imidazoline und verfahren zur herstellung sowie deren verwendung | |
| GB9425559D0 (en) | Use of cyclic animals of glyoxylic acid for trapping hydrogen sulphide | |
| PT79453A (de) | E-triazolyl-pentenole verfahren zur herstellung dieser verbindungen sowie diese enthaltende biozide und wuchsregulatorische mittel |