DE69131572D1 - Nucleinsäure kodierend für transformierenden wachstumsfaktor-beta1 bindendes protein - Google Patents

Nucleinsäure kodierend für transformierenden wachstumsfaktor-beta1 bindendes protein

Info

Publication number
DE69131572D1
DE69131572D1 DE69131572T DE69131572T DE69131572D1 DE 69131572 D1 DE69131572 D1 DE 69131572D1 DE 69131572 T DE69131572 T DE 69131572T DE 69131572 T DE69131572 T DE 69131572T DE 69131572 D1 DE69131572 D1 DE 69131572D1
Authority
DE
Germany
Prior art keywords
nucleic acid
growth factor
binding protein
transforming growth
acid coding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131572T
Other languages
English (en)
Other versions
DE69131572T2 (de
Inventor
Tetsuto Kanzaki
Anders Olofsson
Anita Moren
Christer Wernstedt
Ulf Hellman
Kohei Miyazono
Lena Claesson-Welsh
Carl-Henrik Heldin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Institute for Cancer Research New York
Original Assignee
Ludwig Institute for Cancer Research New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Institute for Cancer Research New York filed Critical Ludwig Institute for Cancer Research New York
Application granted granted Critical
Publication of DE69131572D1 publication Critical patent/DE69131572D1/de
Publication of DE69131572T2 publication Critical patent/DE69131572T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69131572T 1990-02-27 1991-02-20 Nucleinsäure kodierend für transformierenden wachstumsfaktor-beta1 bindendes protein Expired - Fee Related DE69131572T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/487,343 US5177197A (en) 1990-02-27 1990-02-27 Isolated nucleotide sequence expressing human transforming growth factor-β1-binding protein
PCT/US1991/001132 WO1991013152A1 (en) 1990-02-27 1991-02-20 SUBSTANTIALLY PURE TRANSFORMING GROWTH FACTOR-β1-BINDING PROTEIN AND NUCLEOTIDE SEQUENCES EXPRESSING THE BINDING PROTEIN

Publications (2)

Publication Number Publication Date
DE69131572D1 true DE69131572D1 (de) 1999-10-07
DE69131572T2 DE69131572T2 (de) 1999-12-23

Family

ID=23935360

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131572T Expired - Fee Related DE69131572T2 (de) 1990-02-27 1991-02-20 Nucleinsäure kodierend für transformierenden wachstumsfaktor-beta1 bindendes protein

Country Status (7)

Country Link
US (1) US5177197A (de)
EP (1) EP0517779B1 (de)
JP (1) JP3138740B2 (de)
AU (1) AU649026B2 (de)
CA (1) CA2076979C (de)
DE (1) DE69131572T2 (de)
WO (1) WO1991013152A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5229495A (en) * 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
WO1993010215A1 (en) * 1991-11-15 1993-05-27 Memorial Sloan-Kettering Cancer Center Purified proteoglycan betaglycan, compositions, and methods
US5280109A (en) * 1992-01-27 1994-01-18 Ludwig Institute For Cancer Research Isolated, large latent complexes of TGF-β2 and TGF-β3, and new binding protein for latent form TGF-β1, TGF-β2 and TGF-β3 LTBP-2
AU676847B2 (en) * 1992-09-03 1997-03-27 Regeneron Pharmaceuticals, Inc. Dorsal tissue affecting factor and compositions
WO1995006656A1 (en) * 1993-09-03 1995-03-09 The Regents Of The University Of California Neural tissue affecting factor and compositions
US5731195A (en) * 1994-06-10 1998-03-24 Ludwig Institute For Cancer Research Isolated nucleic acid molecule which codes for a 32 kDa protein having 11-cis retinol dehydrogenase activity, and which associates with p63, a portion of a retinol binding protein receptor
US5575124A (en) * 1995-03-29 1996-11-19 Novello, Jr.; Eligio Construction with modular walls
GB9517098D0 (en) * 1995-08-21 1995-10-25 Imperial College Receptor
US5808512A (en) * 1997-01-31 1998-09-15 Ophir Rf, Inc. Feed forward amplifiers and methods
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
DK1133558T4 (en) 1998-11-27 2016-05-17 Ucb Sa Compositions and methods for increasing bone mineralization
US6794938B2 (en) * 2002-03-19 2004-09-21 The University Of North Carolina At Charlotte Method and apparatus for cancellation of third order intermodulation distortion and other nonlinearities
US7799523B2 (en) 2002-04-03 2010-09-21 Celltech R & D, Inc. Association of polymorphisms in the SOST gene region with bone mineral density
JP4688802B2 (ja) 2003-06-16 2011-05-25 セルテック アール アンド ディー， インコーポレイテッド 骨の鉱化作用を増大させるためのスクレロスチンに特異的な抗体および方法
US20080076998A1 (en) * 2003-12-01 2008-03-27 Z-Tech (Canada) Inc. Breast electrode array and method of analysis for detecting and diagnosing diseases
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
SG10201912670XA (en) 2010-05-14 2020-02-27 Amgen Inc High concentration antibody formulations
WO2012118903A2 (en) 2011-03-01 2012-09-07 Amgen Inc. Bispecific binding agents
AP3981A (en) 2011-03-25 2017-01-05 Amgen Inc Anti - sclerostin antibody crystals and formulations thereof
DK2739311T3 (en) 2011-08-04 2018-04-23 Amgen Inc Method of treating bone slit defects
EP2797953B1 (de) 2011-12-28 2020-06-03 Amgen Inc. Verfahren zur behandlung von alveolarknochenverlust durch verwendung von anti-sclerostin-antikörpern
JP6770312B2 (ja) 2012-07-05 2020-10-14 ユセベ ファルマ ソシエテ アノニム 骨疾患の治療
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
JP2020502218A (ja) 2016-12-21 2020-01-23 メレオ バイオファーマ ３ リミテッド 骨形成不全症の処置における抗スクレロスチン抗体の使用
CA3093457A1 (en) 2018-03-30 2019-10-03 Amgen Inc. C-terminal antibody variants

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3382562D1 (de) * 1982-09-24 1992-06-25 Us Health Wiederherstellung von gewebe bei tieren.
GB9106678D0 (en) * 1991-03-28 1991-05-15 Ferguson Mark W J Wound healing
US5229495A (en) * 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof

Also Published As

Publication number Publication date
EP0517779B1 (de) 1999-09-01
EP0517779A4 (en) 1993-03-31
CA2076979A1 (en) 1991-08-28
US5177197A (en) 1993-01-05
WO1991013152A1 (en) 1991-09-05
DE69131572T2 (de) 1999-12-23
EP0517779A1 (de) 1992-12-16
CA2076979C (en) 2001-01-16
AU649026B2 (en) 1994-05-12
JPH05504888A (ja) 1993-07-29
AU7449591A (en) 1991-09-18
JP3138740B2 (ja) 2001-02-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee