DE69131248T2 - Inhibition der ausscheidung von natrium durch die na-k-atpase - Google Patents

Inhibition der ausscheidung von natrium durch die na-k-atpase

Info

Publication number
DE69131248T2
DE69131248T2 DE69131248T DE69131248T DE69131248T2 DE 69131248 T2 DE69131248 T2 DE 69131248T2 DE 69131248 T DE69131248 T DE 69131248T DE 69131248 T DE69131248 T DE 69131248T DE 69131248 T2 DE69131248 T2 DE 69131248T2
Authority
DE
Germany
Prior art keywords
compounds
atpase
inhibition
sodium
separation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131248T
Other languages
English (en)
Other versions
DE69131248D1 (de
Inventor
Harvey Gonick
Elmar Weiler
Farhad Khalil-Manesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Los Angeles UCLA
Original Assignee
University of California
University of California Los Angeles UCLA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, University of California Los Angeles UCLA filed Critical University of California
Publication of DE69131248D1 publication Critical patent/DE69131248D1/de
Application granted granted Critical
Publication of DE69131248T2 publication Critical patent/DE69131248T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C07K4/12—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69131248T 1990-09-11 1991-09-11 Inhibition der ausscheidung von natrium durch die na-k-atpase Expired - Fee Related DE69131248T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58158290A 1990-09-11 1990-09-11
PCT/US1991/006554 WO1992004910A1 (en) 1990-09-11 1991-09-11 Na-k-atpase inhibiting natriuretic substances

Publications (2)

Publication Number Publication Date
DE69131248D1 DE69131248D1 (de) 1999-06-24
DE69131248T2 true DE69131248T2 (de) 1999-12-16

Family

ID=24325750

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131248T Expired - Fee Related DE69131248T2 (de) 1990-09-11 1991-09-11 Inhibition der ausscheidung von natrium durch die na-k-atpase

Country Status (9)

Country Link
US (1) US5667811A (de)
EP (1) EP0500921B1 (de)
AT (1) ATE180167T1 (de)
AU (1) AU650490B2 (de)
CA (1) CA2068412A1 (de)
DE (1) DE69131248T2 (de)
DK (1) DK0500921T3 (de)
OA (1) OA09700A (de)
WO (1) WO1992004910A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044931A2 (en) * 1999-01-28 2000-08-03 Bion, Inc. High-throughput screening assays for modulators of atpase

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321120A (en) * 1980-03-19 1982-03-23 Nardi Ronald V Process for detecting proteins specific to hypertension in mammals
US4665019A (en) * 1983-08-31 1987-05-12 University Of Maryland Method for measuring the plasma levels of an inhibitor of (Na+ +K.sup.+
JPS6060557A (ja) * 1983-09-13 1985-04-08 Eisai Co Ltd Ｐｉｖｋａ−２の測定方法および試薬
US4943533A (en) * 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
DE3445933A1 (de) * 1984-12-17 1986-06-19 Röhm GmbH, 6100 Darmstadt Arzneimittel mit diuretischer wirksamkeit
GB8516081D0 (en) * 1985-06-25 1985-07-31 Ciba Geigy Ag Assay & purification of amyloid components
US4780314A (en) * 1985-10-30 1988-10-25 Brigham And Women's Hospital Isolation and purification of a digitalis-like factor
US4940670A (en) * 1986-01-24 1990-07-10 Rhodes Buck A Method for compounding and testing patient specific monoclonal antibodies and monoclonal antibody fragments for in vivo use
FR2597483B1 (fr) * 1986-04-18 1993-09-10 Flork Michel Nouveaux peptides diuretiques et natriuretiques.
US4746652A (en) * 1986-11-18 1988-05-24 Wake Forest University Method of inducing diuresis with lysophospholipids
US4940782A (en) * 1987-06-08 1990-07-10 G. D. Searle & Co. Monoclonal antibodies against IgE-associated determinants, hybrid cell lines producing these antibodies, and use therefore

Also Published As

Publication number Publication date
DK0500921T3 (da) 1999-11-29
US5667811A (en) 1997-09-16
DE69131248D1 (de) 1999-06-24
CA2068412A1 (en) 1992-03-12
WO1992004910A1 (en) 1992-04-02
EP0500921A4 (en) 1993-05-26
AU650490B2 (en) 1994-06-23
OA09700A (en) 1993-08-30
EP0500921B1 (de) 1999-05-19
ATE180167T1 (de) 1999-06-15
AU8761791A (en) 1992-04-15
EP0500921A1 (de) 1992-09-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee