DE69131206D1 - Lumineszierende lanthanidenchelate - Google Patents

Lumineszierende lanthanidenchelate

Info

Publication number
DE69131206D1
DE69131206D1 DE69131206T DE69131206T DE69131206D1 DE 69131206 D1 DE69131206 D1 DE 69131206D1 DE 69131206 T DE69131206 T DE 69131206T DE 69131206 T DE69131206 T DE 69131206T DE 69131206 D1 DE69131206 D1 DE 69131206D1
Authority
DE
Germany
Prior art keywords
lanthanide chelates
luminescent lanthanide
luminescent
chelates
lanthanide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131206T
Other languages
English (en)
Other versions
DE69131206T2 (de
Inventor
Harri Takalo
Veli-Matti Mukkala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wallac Oy
Original Assignee
Wallac Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wallac Oy filed Critical Wallac Oy
Publication of DE69131206D1 publication Critical patent/DE69131206D1/de
Application granted granted Critical
Publication of DE69131206T2 publication Critical patent/DE69131206T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69131206T 1991-12-05 1991-12-05 Lumineszierende lanthanidenchelate Expired - Fee Related DE69131206T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/FI1991/000373 WO1993011433A1 (en) 1991-12-05 1991-12-05 Luminescent lanthanide chelates

Publications (2)

Publication Number Publication Date
DE69131206D1 true DE69131206D1 (de) 1999-06-10
DE69131206T2 DE69131206T2 (de) 2000-01-05

Family

ID=8556519

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131206T Expired - Fee Related DE69131206T2 (de) 1991-12-05 1991-12-05 Lumineszierende lanthanidenchelate

Country Status (5)

Country Link
US (1) US5571897A (de)
EP (1) EP0626068B1 (de)
DE (1) DE69131206T2 (de)
ES (1) ES2133312T3 (de)
WO (1) WO1993011433A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760191A (en) * 1993-02-05 1998-06-02 Nycomed Imaging As Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods
WO1995008642A1 (en) * 1993-09-23 1995-03-30 Zeneca Limited Nucleic acid detection with energy transfer
US5457186A (en) * 1993-10-13 1995-10-10 Wallac Oy Luminescent lanthanide chelates with decreased non-radiative energy loss
US5859215A (en) * 1995-10-25 1999-01-12 Wallac Oy Biospecific binding reactants labelled with luminescent lanthanide chelates and their use
US5861138A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Ligands for MRI contrast agent
US5861140A (en) * 1996-11-20 1999-01-19 Hoechst Celanese Corp. Tripodal paramagnetic contrast agents for MR imaging
GB9711237D0 (en) * 1997-06-02 1997-07-23 Isis Innovation Organomettallic Complexes
US5820851A (en) * 1997-08-21 1998-10-13 Hoechst Celanese Corporation Tripodal pyridine ligands as MRI contrast agents
US5824288A (en) * 1997-08-21 1998-10-20 Hoechst Celanese Corporation Thio-substituted pyridines as MRI ligand precursors
US5869026A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corp. Tripodal carboxamide ligands for MRI contrast agents
US5858329A (en) * 1997-08-21 1999-01-12 Hoechst Celanese Corporation MRI diagnostic procedures using tripodal pyridinyl metal complexes
US5869025A (en) * 1997-08-21 1999-02-09 Hoechst Celanese Corporation Tripodal aromatic heterocycle carboxamide MRI contrast agents
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6080839A (en) * 1998-06-25 2000-06-27 Wallac Oy Labeling reactants and their use
GB9813776D0 (en) 1998-06-25 1998-08-26 Smithkline Beecham Plc Novel compounds
DE19860289C2 (de) * 1998-12-21 2003-11-13 Schering Ag Neue Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium
ATE270298T1 (de) * 1999-01-19 2004-07-15 Robert C Leif Reaktionssystem und verfahren zur verstärkung der lumineszenz von makrocyclischen lanthanid(iii)- komplexen
GB0022081D0 (en) * 2000-09-08 2000-10-25 Isis Innovation Pyrazolone lanthanide complexes
JP3600832B2 (ja) * 2002-01-28 2004-12-15 株式会社富士薬品 新規１，２，４−トリアゾール系化合物
US7465747B2 (en) 2002-03-08 2008-12-16 Kazuko Matsumoto Fluorescent label compounds
EP1506402A2 (de) * 2002-03-28 2005-02-16 Rutgers, The State University of New Jersey Bis-übergangsmetall-chelat probe
US7018851B2 (en) * 2003-02-13 2006-03-28 Innotrac Diagnostics Oy Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
US7619059B2 (en) 2003-07-29 2009-11-17 Life Technologies Corporation Bimolecular optical probes
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
EP1771440A4 (de) * 2004-07-23 2009-09-02 Amgen Inc Generische proben zur detektion phosphorylierter sequenzen
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
JP5070057B2 (ja) * 2005-08-31 2012-11-07 独立行政法人科学技術振興機構 新規な蛍光標識化合物
EP2221385A3 (de) 2005-10-28 2010-12-01 Life Technologies Corporation Deubiquinations-Assays
US7482444B2 (en) * 2006-03-13 2009-01-27 Wallac Oy Terminating substrates for DNA polymerases
PT2001849E (pt) 2006-03-29 2015-02-05 Hoffmann La Roche Derivados de piridina e pirimidina como antagonistas de r2mglu
JP5237949B2 (ja) 2006-08-18 2013-07-17 アバクス ディアグノスティカ オイ 発光性ランタノイド標識試薬及びその用途
US7679745B2 (en) * 2006-11-21 2010-03-16 Neptec Optical Solutions Time-resolved fluorescence spectrometer for multiple-species analysis
FI20070508A0 (fi) * 2007-06-27 2007-06-27 Turun Yliopisto Peptidisubstraatti ja sen käyttö
US8889839B2 (en) * 2008-05-07 2014-11-18 Syracuse University Pyridine-bis (oxazoline)(“pybox”) moiety as a chelator and sensitizer for lanthanide ion (Ln (III)) Luminescence
WO2010006605A2 (en) * 2008-07-16 2010-01-21 Radiometer Medical Aps Thrombin substrate and assay for determining the level of bioactive thrombin in a sample
US20100144046A1 (en) * 2008-12-04 2010-06-10 Bio-Rad Laboratories, Inc. Cyclometalated transition metal complexes for multiplex analyte detection
CN107266433A (zh) * 2010-11-09 2017-10-20 铁木医药有限公司 sGC刺激剂
JP6153951B2 (ja) 2012-03-16 2017-06-28 スタット−ダイアグノスティカ アンド イノベーション， エス． エル． 統合された移送モジュールを有する試験カートリッジ
WO2014136115A1 (en) 2013-03-07 2014-09-12 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Non-selfabsorbing luminescent solar concentrator
CN109369635B (zh) 2013-03-15 2023-06-30 赛克里翁治疗有限公司 化合物或其药学上可接受的盐及其应用和药物组合物
US9638690B2 (en) 2014-11-07 2017-05-02 The University Of British Columbia Compounds and compositions for use as alkylating agent sensors and methods of use thereof
WO2018114772A1 (en) 2016-12-21 2018-06-28 F. Hoffmann-La Roche Ag Assay for determining antibody or ligand binding and function
FR3092115B1 (fr) 2019-01-30 2021-11-12 Cisbio Bioassays analogues de GTP fluorescents et utilisation
WO2023238683A1 (ja) * 2022-06-06 2023-12-14 国立大学法人電気通信大学 新規複素環式化合物及びその塩、並びに発光基質組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837169A (en) * 1981-07-01 1989-06-06 Eastman Kodak Company Polypyridine Fluorescent labels for immunoassay
FR2570703B1 (fr) * 1984-09-26 1988-07-08 Commissariat Energie Atomique Complexes macropolycycliques de terres rares et application a titre de marqueurs fluorescents
US4761481A (en) * 1985-03-18 1988-08-02 Baxter Travenol Laboratories, Inc. Substituted pyridine derivatives
US4925804A (en) * 1986-06-17 1990-05-15 Baxter International Inc. Interligand metal transfer assay
US5032677A (en) * 1987-11-06 1991-07-16 Baxter International Inc. Fluorescent poly(arylpyridine) rare earth chelates
US5162508A (en) * 1987-12-18 1992-11-10 Compagnie Oris Industrie Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
FR2624862B1 (fr) * 1987-12-18 1990-06-08 Oris Ind Cryptates de terres rares, procedes d'obtention, intermediaires de synthese et application a titre de marqueurs fluorescents
SE8802575D0 (sv) * 1988-07-08 1988-07-08 Wallac Oy Terpyridine derivatives
US5202423A (en) * 1988-07-08 1993-04-13 Wallac Oy Terpyridine derivatives

Also Published As

Publication number Publication date
US5571897A (en) 1996-11-05
ES2133312T3 (es) 1999-09-16
WO1993011433A1 (en) 1993-06-10
EP0626068B1 (de) 1999-05-06
EP0626068A1 (de) 1994-11-30
DE69131206T2 (de) 2000-01-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee