DE69130832D1 - Injizierbare amphotericin b enthaltende dispersion - Google Patents
Injizierbare amphotericin b enthaltende dispersionInfo
- Publication number
- DE69130832D1 DE69130832D1 DE69130832T DE69130832T DE69130832D1 DE 69130832 D1 DE69130832 D1 DE 69130832D1 DE 69130832 T DE69130832 T DE 69130832T DE 69130832 T DE69130832 T DE 69130832T DE 69130832 D1 DE69130832 D1 DE 69130832D1
- Authority
- DE
- Germany
- Prior art keywords
- amphotericin
- dispersion
- injectable
- preparation
- itself
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 title abstract 4
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 title abstract 4
- 229960003942 amphotericin b Drugs 0.000 title abstract 4
- 239000006185 dispersion Substances 0.000 title abstract 3
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31205790 | 1990-11-16 | ||
| PCT/JP1991/001564 WO1992008467A1 (en) | 1990-11-16 | 1991-11-15 | Dispersion preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69130832D1 true DE69130832D1 (de) | 1999-03-11 |
| DE69130832T2 DE69130832T2 (de) | 1999-10-07 |
Family
ID=18024709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69130832T Expired - Fee Related DE69130832T2 (de) | 1990-11-16 | 1991-11-15 | Injizierbare amphotericin b enthaltende dispersion |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5776904A (de) |
| EP (1) | EP0558750B1 (de) |
| JP (1) | JP3074734B2 (de) |
| AT (1) | ATE176155T1 (de) |
| DE (1) | DE69130832T2 (de) |
| WO (1) | WO1992008467A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291436B1 (en) | 1999-07-16 | 2001-09-18 | International Fiber Corporation | Direct action anti-mycotic |
| US6413537B1 (en) | 2000-03-10 | 2002-07-02 | Wisconsin Alumni Research Foundation | Nystatin formulation having reduced toxicity |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| CA2432319A1 (en) | 2000-12-21 | 2002-07-18 | Nektar Therapeutics | Pulmonary delivery of polyene antifungal agents |
| KR20020062494A (ko) * | 2001-01-22 | 2002-07-26 | 유봉규 | 단량체 폴리엔마크로리드계열 항생제를 함유한 고체분산체조성물 |
| DE60320283T2 (de) * | 2002-10-03 | 2009-08-27 | University of Mississippi, University | Zusammensetzungen mit Amphotericin B enthaltend weniger als 4% Verunreinigungen |
| CA2567785A1 (en) * | 2004-06-21 | 2006-01-05 | Nektar Therapeutics | Composition comprising amphotericin b methods and systems |
| US8513204B2 (en) * | 2004-06-21 | 2013-08-20 | Novartis Ag | Compositions comprising amphotericin B, mehods and systems |
| EP1848541A4 (de) * | 2005-02-07 | 2013-01-16 | Pharmalight Inc | Verfahren und vorrichtung zur ophthalmischen verabreichung von pharmazeutischen wirksstoffen |
| WO2008063756A2 (en) * | 2006-10-03 | 2008-05-29 | Accentia Biopharmaceuticals, Inc. | Mucosally non-irritative amphotericin b formulations and methods for treating non-invasive fungus-induced mucositis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928570A (en) * | 1971-11-29 | 1975-12-23 | Squibb & Sons Inc | Amphotericin complexes |
| US4002741A (en) * | 1974-04-24 | 1977-01-11 | Valter Osvaldovich Kulbakh | Meglumine complex fungicidal polyene macrolide antibiotic compositions and treatment method |
| US4035567A (en) * | 1975-10-21 | 1977-07-12 | E. R. Squibb & Sons, Inc. | Process for producing the methyl ester of amphotericin B |
| HU196230B (en) * | 1983-12-29 | 1988-10-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing water-soluble forms of polyene antibiotics and pharmaceutics comprising such active ingredient and plant protective with antifungal effect |
| US5043107A (en) * | 1986-08-21 | 1991-08-27 | Vestar Research, Inc. | Preparation small unilamellar vesicles including polyene antifungal antibiotics |
| FR2604903B1 (fr) * | 1986-10-08 | 1989-01-13 | Sopar Sa Nv | Agents therapeutiques sous forme de particules submicroscopiques contre des parasitoses et compositions pharmaceutiques les contenant |
| US4822777A (en) * | 1987-02-27 | 1989-04-18 | Liposome Technology, Inc. | Amphotericin B/cholesterol sulfate composition |
| US4950477A (en) * | 1988-08-23 | 1990-08-21 | Memorial Hospital For Cancer And Allied Dieseas | Method of preventing and treating pulmonary infection by fungi using aerosolized polyenes |
-
1991
- 1991-11-15 DE DE69130832T patent/DE69130832T2/de not_active Expired - Fee Related
- 1991-11-15 US US08/050,217 patent/US5776904A/en not_active Expired - Fee Related
- 1991-11-15 EP EP91919697A patent/EP0558750B1/de not_active Expired - Lifetime
- 1991-11-15 WO PCT/JP1991/001564 patent/WO1992008467A1/ja active IP Right Grant
- 1991-11-15 JP JP03518215A patent/JP3074734B2/ja not_active Expired - Lifetime
- 1991-11-15 AT AT91919697T patent/ATE176155T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0558750A4 (en) | 1993-10-20 |
| WO1992008467A1 (en) | 1992-05-29 |
| EP0558750B1 (de) | 1999-01-27 |
| DE69130832T2 (de) | 1999-10-07 |
| ATE176155T1 (de) | 1999-02-15 |
| JP3074734B2 (ja) | 2000-08-07 |
| EP0558750A1 (de) | 1993-09-08 |
| US5776904A (en) | 1998-07-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |