DE69120936D1 - Genetischer test für zytochrom-p450 - Google Patents

Genetischer test für zytochrom-p450

Info

Publication number
DE69120936D1
DE69120936D1 DE69120936T DE69120936T DE69120936D1 DE 69120936 D1 DE69120936 D1 DE 69120936D1 DE 69120936 T DE69120936 T DE 69120936T DE 69120936 T DE69120936 T DE 69120936T DE 69120936 D1 DE69120936 D1 DE 69120936D1
Authority
DE
Germany
Prior art keywords
zytochrom
genetic test
metaboliser
enzyme
bufuralol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69120936T
Other languages
English (en)
Other versions
DE69120936T2 (de
Inventor
Charles Roland Imperial C Wolf
John Miles
Nigel Spurr
Alan Gough
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Technology Ltd
Original Assignee
Imperial Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10669529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69120936(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Imperial Cancer Research Technology Ltd filed Critical Imperial Cancer Research Technology Ltd
Application granted granted Critical
Publication of DE69120936D1 publication Critical patent/DE69120936D1/de
Publication of DE69120936T2 publication Critical patent/DE69120936T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)
DE69120936T 1990-01-18 1991-01-17 Genetischer test für zytochrom-p450 Expired - Lifetime DE69120936T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909001181A GB9001181D0 (en) 1990-01-18 1990-01-18 Genetic assay
PCT/GB1991/000066 WO1991010745A1 (en) 1990-01-18 1991-01-17 Genetic assay for cytochrome p450

Publications (2)

Publication Number Publication Date
DE69120936D1 true DE69120936D1 (de) 1996-08-22
DE69120936T2 DE69120936T2 (de) 1997-02-20

Family

ID=10669529

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69120936T Expired - Lifetime DE69120936T2 (de) 1990-01-18 1991-01-17 Genetischer test für zytochrom-p450

Country Status (9)

Country Link
US (1) US5981174A (de)
EP (1) EP0511262B1 (de)
JP (1) JP3272353B2 (de)
AT (1) ATE140488T1 (de)
AU (1) AU642705C (de)
CA (1) CA2071636C (de)
DE (1) DE69120936T2 (de)
GB (1) GB9001181D0 (de)
WO (1) WO1991010745A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115364B1 (en) 1993-10-26 2006-10-03 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US20060229824A1 (en) 1993-10-26 2006-10-12 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes
DE69434912T2 (de) * 1993-12-08 2007-10-25 Royal Veterinary & Agricultural University Monooxygenase cytochrome p-450
JP3564579B2 (ja) * 1994-05-06 2004-09-15 大塚製薬株式会社 ヒトチトクロームｐ４５０２ｄ６遺伝子多型の検出方法
EP0723021A1 (de) * 1994-07-06 1996-07-24 Otsuka Pharmaceutical Co., Ltd. Methode der detektion des cytochrom p4501a2 genpolymorphismus in mensch
US6391550B1 (en) 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
US6183963B1 (en) * 1998-10-23 2001-02-06 Signalgene Detection of CYP1A1, CYP3A4, CYP2D6 and NAT2 variants by PCR-allele-specific oligonucleotide (ASO) assay
EP1088900A1 (de) * 1999-09-10 2001-04-04 Epidauros Biotechnologie AG Polymorphismen des menschlichen CYP3A4, CYP3A7 und hPXR Gene, und ihre Anwendung in Diagnose und Therapie
JP4721603B2 (ja) * 1999-11-08 2011-07-13 栄研化学株式会社 変異および／または多型の検出方法
EP1231281B1 (de) * 1999-11-08 2006-02-01 Eiken Kagaku Kabushiki Kaisha Methode zum nachweis von variationen oder polymorphismen
CN100422323C (zh) * 2000-04-07 2008-10-01 荣研化学株式会社 使用双链核酸为模板扩增核酸的方法
US7229756B1 (en) 2000-10-19 2007-06-12 University Of Cincinnati Alpha-2B-adrenergic receptor polymorphisms
AU2001255448A1 (en) * 2000-04-17 2001-10-30 Stephen B. Liggett Alpha-2 adrenergic receptor polymorphisms
WO2001096604A2 (en) * 2000-06-12 2001-12-20 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
US7211386B2 (en) * 2000-08-10 2007-05-01 University Of Cincinnati Alpha-2A-adrenergic receptor polymorphisms
US20030166182A1 (en) * 2001-03-30 2003-09-04 Wei Shao Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
EP1339879A4 (de) * 2001-06-05 2004-12-29 Genaissance Pharmaceuticals Verfahren zum identifizieren von polymorphismen in cyp2d6
US20040096874A1 (en) * 2002-04-11 2004-05-20 Third Wave Technologies, Inc. Characterization of CYP 2D6 genotypes
US20040091909A1 (en) * 2002-07-05 2004-05-13 Huang Doug Hui High throughput cytochrome P450 genotyping
JP2005328758A (ja) * 2004-05-20 2005-12-02 Hitachi Ltd 核酸増幅方法及びこれを利用した一塩基多型の解析
CA2571823A1 (en) * 2004-06-30 2006-01-12 Tm Bioscience Pgx, Inc. Method of detecting mutations in the gene encoding cytochrome p450-2d6
WO2006014869A1 (en) * 2004-07-26 2006-02-09 Parallele Bioscience, Inc. Simultaneous analysis of multiple genomes
DE602005021525D1 (de) 2004-09-14 2010-07-08 Univ Colorado R behandlung mit bucindolol
CA2582022C (en) 2004-09-30 2021-05-18 Vanda Pharmaceuticals, Inc. Methods for the administration of iloperidone
US20100063093A1 (en) * 2007-03-28 2010-03-11 Curt Wolfgang Methods for the administration of iloperidone
US7368242B2 (en) * 2005-06-14 2008-05-06 Affymetrix, Inc. Method and kits for multiplex hybridization assays
US9408854B2 (en) 2009-10-19 2016-08-09 Rostaquo S.P.A. Methods and systems for pharmacogenomic treatment of cardiovascular conditions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE61148B1 (en) * 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
DE69126064T2 (de) * 1990-06-22 1997-08-28 Hoffmann La Roche Nachweis von schwachen Metabolisierungsreagentien von Drogen

Also Published As

Publication number Publication date
GB9001181D0 (en) 1990-03-21
AU642705B2 (en) 1993-10-28
WO1991010745A1 (en) 1991-07-25
EP0511262A1 (de) 1992-11-04
ATE140488T1 (de) 1996-08-15
JPH05503845A (ja) 1993-06-24
DE69120936T2 (de) 1997-02-20
JP3272353B2 (ja) 2002-04-08
CA2071636A1 (en) 1991-07-19
EP0511262B1 (de) 1996-07-17
CA2071636C (en) 2001-12-25
AU642705C (en) 2001-07-19
AU7179191A (en) 1991-08-05
US5981174A (en) 1999-11-09

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Legal Events

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8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: CANCER RESEARCH TECHNOLOGY LTD., LONDON, GB