DE69117431D1 - Thienoimidazolderivate, ihre Herstellung und Verwendung - Google Patents

Thienoimidazolderivate, ihre Herstellung und Verwendung

Info

Publication number
DE69117431D1
DE69117431D1 DE69117431T DE69117431T DE69117431D1 DE 69117431 D1 DE69117431 D1 DE 69117431D1 DE 69117431 T DE69117431 T DE 69117431T DE 69117431 T DE69117431 T DE 69117431T DE 69117431 D1 DE69117431 D1 DE 69117431D1
Authority
DE
Germany
Prior art keywords
group
diseases
ring
production
heart
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69117431T
Other languages
English (en)
Other versions
DE69117431T2 (de
Inventor
Takehiko Naka
Yoshiyuki Inada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69117431D1 publication Critical patent/DE69117431D1/de
Application granted granted Critical
Publication of DE69117431T2 publication Critical patent/DE69117431T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Steroid Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69117431T 1990-10-30 1991-10-25 Thienoimidazolderivate, ihre Herstellung und Verwendung Expired - Fee Related DE69117431T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP29465590 1990-10-30
JP9208191 1991-04-23
JP15064391 1991-06-21

Publications (2)

Publication Number Publication Date
DE69117431D1 true DE69117431D1 (de) 1996-04-04
DE69117431T2 DE69117431T2 (de) 1996-06-13

Family

ID=27306934

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69117431T Expired - Fee Related DE69117431T2 (de) 1990-10-30 1991-10-25 Thienoimidazolderivate, ihre Herstellung und Verwendung

Country Status (13)

Country Link
US (1) US5463073A (de)
EP (1) EP0483683B1 (de)
KR (1) KR920008046A (de)
CN (1) CN1061973A (de)
AT (1) ATE134633T1 (de)
AU (1) AU636066B2 (de)
DE (1) DE69117431T2 (de)
FI (1) FI915099A0 (de)
HU (1) HUT62005A (de)
IE (1) IE913773A1 (de)
MX (1) MX9101768A (de)
NO (1) NO914236L (de)
PT (1) PT99357A (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU653524B2 (en) * 1990-06-08 1994-10-06 Roussel-Uclaf New imidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them
TW274551B (de) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
DE69330593T2 (de) * 1992-12-22 2002-06-27 Takeda Chemical Industries, Ltd. Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
JP3810020B2 (ja) 1993-04-22 2006-08-16 武田薬品工業株式会社 腎疾患の予防または治療剤
US5721263A (en) 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
CA2466659A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticancer agents
US7232828B2 (en) * 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
DE10341240A1 (de) * 2003-09-08 2005-04-07 Aventis Pharma Deutschland Gmbh Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US20070282099A1 (en) * 2006-06-02 2007-12-06 Steffen Zahn Heterocyclic fused imidazolone, dioxolone, imidazolethione and dioxolethione monomers
EP2253630A1 (de) 2007-05-21 2010-11-24 Takeda Pharmaceutical Company Limited Heterocyclische Verbindung und ihre Verwendung
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP3241839B1 (de) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
US5164407A (en) * 1989-07-03 1992-11-17 Merck & Co., Inc. Substituted imidazo-fused 5-membered ring heterocycles and their use as angiotensin ii antagonsists
EP0411507B1 (de) * 1989-08-02 1994-10-26 Takeda Chemical Industries, Ltd. Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
AU653524B2 (en) * 1990-06-08 1994-10-06 Roussel-Uclaf New imidazole derivatives, their preparation process, the new intermediates obtained, their use as medicaments and the pharmaceutical compositions containing them

Also Published As

Publication number Publication date
NO914236L (no) 1992-05-04
EP0483683A3 (en) 1992-06-03
IE913773A1 (en) 1992-05-22
EP0483683A2 (de) 1992-05-06
KR920008046A (ko) 1992-05-27
FI915099A (fi) 1992-08-11
MX9101768A (es) 1992-06-05
PT99357A (pt) 1992-09-30
EP0483683B1 (de) 1996-02-28
AU8670791A (en) 1992-05-07
NO914236D0 (no) 1991-10-29
CN1061973A (zh) 1992-06-17
FI915099A0 (fi) 1992-08-11
AU636066B2 (en) 1993-04-08
US5463073A (en) 1995-10-31
HU913417D0 (en) 1992-01-28
HUT62005A (en) 1993-03-29
ATE134633T1 (de) 1996-03-15
DE69117431T2 (de) 1996-06-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee