DE69116057D1 - Mikrobische Herstellung des 13-beta-13-deoxy-22,23,-dihydroavermectin-Bla/B1b-Aglycons - Google Patents

Mikrobische Herstellung des 13-beta-13-deoxy-22,23,-dihydroavermectin-Bla/B1b-Aglycons

Info

Publication number
DE69116057D1
DE69116057D1 DE69116057T DE69116057T DE69116057D1 DE 69116057 D1 DE69116057 D1 DE 69116057D1 DE 69116057 T DE69116057 T DE 69116057T DE 69116057 T DE69116057 T DE 69116057T DE 69116057 D1 DE69116057 D1 DE 69116057D1
Authority
DE
Germany
Prior art keywords
dihydroavermectin
aglycone
bla
deoxy
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69116057T
Other languages
English (en)
Inventor
Kalinka Shumanov
Raymond F White
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69116057D1 publication Critical patent/DE69116057D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/545—Streptomyces griseus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/56—Streptomyces lavendulae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/82—Subcellular parts of microorganisms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69116057T 1990-09-24 1991-09-18 Mikrobische Herstellung des 13-beta-13-deoxy-22,23,-dihydroavermectin-Bla/B1b-Aglycons Expired - Lifetime DE69116057D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/587,290 US5225338A (en) 1990-09-24 1990-09-24 Microbial preparation of 13β-13-deoxy-22,23-dihydro avermectin-B1A/B1B aglycone

Publications (1)

Publication Number Publication Date
DE69116057D1 true DE69116057D1 (de) 1996-02-15

Family

ID=24349196

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69116057T Expired - Lifetime DE69116057D1 (de) 1990-09-24 1991-09-18 Mikrobische Herstellung des 13-beta-13-deoxy-22,23,-dihydroavermectin-Bla/B1b-Aglycons

Country Status (8)

Country Link
US (1) US5225338A (de)
EP (1) EP0478064B1 (de)
JP (1) JPH0691831B2 (de)
AU (1) AU644013B2 (de)
CA (1) CA2050826A1 (de)
DE (1) DE69116057D1 (de)
NZ (1) NZ239808A (de)
ZA (1) ZA917556B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5290804A (en) * 1991-05-01 1994-03-01 Merck & Co., Inc. Anthelmintic milbemycin analogs of novel microorganisms
EP0524686A1 (de) * 1991-07-23 1993-01-27 Merck & Co. Inc. Verfahren zur 14a-Hydroxylierung von Avermectin-Verbindungen
WO1999017760A2 (en) 1997-10-02 1999-04-15 Microcide Pharmaceuticals, Inc. Fungal or mammalian cell efflux pump inhibitors for enhancing susceptibility of the cell to a drug
US20090159259A1 (en) * 2006-06-30 2009-06-25 Sunil Kumar Sinha Modular heat pump liquid heater system

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587247A (en) * 1985-02-25 1986-05-06 Merck & Co., Inc. Substituted and unsubstituted 13-(alkoxy)methoxy derivatives of the avermectin aglycones, compositions and use
US4666937A (en) * 1985-03-04 1987-05-19 Merck & Co., Inc. Avermectin bioconversion products
DE3889676D1 (de) * 1987-02-04 1994-06-30 Ciba Geigy Mikrobielles Verfahren zur Herstellung von Milbemycin-Derivaten.

Also Published As

Publication number Publication date
AU644013B2 (en) 1993-12-02
ZA917556B (en) 1992-05-27
EP0478064A2 (de) 1992-04-01
EP0478064B1 (de) 1996-01-03
CA2050826A1 (en) 1992-03-25
JPH04261180A (ja) 1992-09-17
US5225338A (en) 1993-07-06
JPH0691831B2 (ja) 1994-11-16
AU8470991A (en) 1992-03-26
NZ239808A (en) 1993-11-25
EP0478064A3 (en) 1993-04-07

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Legal Events

Date Code Title Description
8332 No legal effect for de